公开(公告)号：US20240207200A1

公开(公告)日：2024-06-27

申请号：US18555329

申请日：2022-04-12

Applicant: DSM IP Assets B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  Luis Fernando MONTEIRO TAMASSIA ,  René Tobias STEMMLER ,  Nicola WALKER

IPC: A61K31/045 ,  A23K20/105 ,  A23K50/10 ,  A61K9/00 ,  A61K31/015 ,  A61P1/14

CPC classification number: A61K31/045 ,  A23K20/105 ,  A23K50/10 ,  A61K9/0056 ,  A61K31/015 ,  A61P1/14

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the administration of limonene and propanediol mononitrate to a ruminant for reducing the production of methane emanating from the digestive activities of said ruminant.

公开(公告)号：US20210037855A1

公开(公告)日：2021-02-11

申请号：US17041757

申请日：2019-03-29

Applicant: DSM IP ASSETS B.V.

Inventor： Laure CLASADONTE ,  André DUESTERLOH ,  Weerasinghe INDRASENA ,  Thomas NETSCHER ,  René Tobias STEMMLER

IPC: A23K20/121 ,  C07D493/08 ,  A23K10/22 ,  A23K20/158 ,  A23K20/174 ,  A23K20/111 ,  A23K50/30 ,  A23K50/40 ,  A23K50/75

Abstract: The present invention is directed towards the use of at least one compound of formula (I) wherein R1, R2 and R3 are independently from each other H or linear C1-6-alkyl or branched C3-8-alkyl, as antioxidant, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oils such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such twin chromanols of formula (I).

公开(公告)号：US20180170885A1

公开(公告)日：2018-06-21

申请号：US15571104

申请日：2016-05-12

Applicant: DSM IP ASSETS B.V.

Inventor： Nadine GREINER ,  Sandro SCHMID ,  René Tobias STEMMLER

IPC: C07D251/24

CPC classification number: C07D251/24

Abstract: The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I), wherein R1 is hydrogen, a C1-C18alkyl group or a C2-C18alkenyl group and R2 is a C1-C18alkyl group or a C2-C18alkenyl group. (I)

公开(公告)号：US20240207203A1

公开(公告)日：2024-06-27

申请号：US18555095

申请日：2022-04-12

Applicant: DSM IP Assets B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  Luis Fernando MONTEIRO TAMASSIA ,  René Tobias STEMMLER ,  Nicola WALKER

IPC: A61K31/11 ,  A61K31/045 ,  A61K47/02 ,  A61K47/10 ,  A61P1/14

CPC classification number: A61K31/11 ,  A61K31/045 ,  A61K47/02 ,  A61K47/10 ,  A61P1/14

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the administration of gossypol and propanediol mononitrate to a ruminant for reducing the production of methane emanating from the digestive activities of said ruminant.

公开(公告)号：US20150321986A1

公开(公告)日：2015-11-12

申请号：US14652339

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Thomas NETSCHER ,  Jonathan Alan MEDLOCK ,  René Tobias STEMMLER ,  Gerardus Karel Maria VERZIJL ,  Andreas Hendrikus Maria DE VRIES

IPC: C07C45/62 ,  C07C50/14 ,  C07D311/58 ,  C07C45/82 ,  C07C43/303

CPC classification number: C07C45/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C43/303 ,  C07C45/82 ,  C07C50/14 ,  C07D311/58 ,  C07C49/203 ,  C07C49/04 ,  C07C47/02

Abstract: The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.

Abstract translation: 本发明涉及由具有前手性双键的不饱和化合物的E / Z异构体的混合物制造具有立体中心化合物的方法。 氢化产物在立体中心处具有特定的所需构型。 该方法涉及两个不对称氢化步骤。 该方法非常有利，因为它以有效的方式从起始产物的立体异构体的混合物形成所需的手性产物。

公开(公告)号：US20150315113A1

公开(公告)日：2015-11-05

申请号：US14651510

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： René Tobias STEMMLER ,  Nadine GREINER

IPC: C07C45/67 ,  C07C321/30 ,  C07C43/313 ,  C07D319/06

CPC classification number: C07C43/313 ,  C07B2200/09 ,  C07C45/67 ,  C07C321/30 ,  C07D319/06 ,  C07C49/203

Abstract: The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsaturated carboxylic acids, esters of an unsaturated carboxylic acid and amides of an unsaturated carboxylic acid using polythiol as cis/trans isomerization catalyst. It has been observed that the isomerization is very efficient and fast.

Abstract translation: 本发明涉及不饱和化合物A的顺式/反式异构化方法，其选自不饱和酮，不饱和缩酮，不饱和醛，不饱和缩醛，不饱和羧酸，不饱和羧酸的酯和酰胺的酰胺 使用多硫醇作为顺式/反式异构化催化剂的不饱和羧酸。 已经观察到异构化非常有效和快速。

公开(公告)号：US20240216294A1

公开(公告)日：2024-07-04

申请号：US18554922

申请日：2022-04-12

Applicant: DSM IP ASSETS B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  Luis Fernando MONTEIRO TAMASSIA ,  René Tobias STEMMLER ,  Nicola WALKER

IPC: A61K31/047 ,  A23K20/105 ,  A23K20/111 ,  A23K50/10 ,  A61K31/05 ,  A61K31/11 ,  A61K31/7024 ,  A61P1/14

CPC classification number: A61K31/047 ,  A23K20/105 ,  A23K20/111 ,  A23K50/10 ,  A61K31/05 ,  A61K31/11 ,  A61K31/7024 ,  A61P1/14

Abstract: The present invention relates to the use of propanediol mononitrate in combination with certain natural substances for reducing the production of methane emanating from the digestive activities of said ruminant as well as in increasing the organic matter digestibility in said ruminant.

公开(公告)号：US20240196932A1

公开(公告)日：2024-06-20

申请号：US18554886

申请日：2022-04-12

Applicant: DSM IP Assets B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  Luis Fernando MONTEIRO TAMASSIA ,  René Tobias STEMMLER ,  Nicola WALKER

IPC: A23K20/111 ,  A23K20/174 ,  A23K20/20 ,  A23K50/10

CPC classification number: A23K20/111 ,  A23K20/174 ,  A23K20/30 ,  A23K50/10

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly. it relates to the administration of gossypol in an amount of at least 7.5 g gossypol/animal/day to a ruminant for reducing the production of methane emanating from the diges-5tive activities of said ruminant.

公开(公告)号：US20150329457A1

公开(公告)日：2015-11-19

申请号：US14652303

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Thomas NETSCHER ,  Jonathan Alan MEDLOCK ,  René Tobias STEMMLER ,  Johannes TSCHUMI ,  Gerardus Karel Maria VERZIJL ,  Andreas Hendrikus Maria DE VRIES

IPC: C07C45/62 ,  C07C45/59

CPC classification number: C07C29/17 ,  C07B2200/07 ,  C07C29/44 ,  C07C45/511 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C45/71 ,  C07C45/90 ,  C07D311/58 ,  C07D319/06 ,  C07F9/5045 ,  C07F15/0033 ,  C07C49/203 ,  C07C49/04 ,  C07C33/025 ,  C07C33/042

Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.

Abstract translation: 本发明涉及从6,10-二甲基十烯-5-烯-2-酮或6,10-二甲基十一碳烯的多步合成中制备（6R，10R）-6,10,14-三甲基十五烷-2-酮的方法 -5,9-二烯-2-酮。 该方法非常有利，因为它以有效的方式形成来自起始产物的立体异构体的混合物的所需手性产物。

公开(公告)号：US20150329456A1

公开(公告)日：2015-11-19

申请号：US14652297

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Werner BONRATH ,  Thomas NETSCHER ,  Jonathan Alan MEDLOCK ,  René Tobias STEMMLER ,  Johannes TSCHUMI ,  Gerardus Karel Maria VERZIJL ,  Andreas Hendrikus Maria DE VRIES

IPC: C07C45/62 ,  C07C29/17 ,  C07C43/313 ,  C07D317/12 ,  C07D319/06 ,  C07C29/42 ,  C07D311/72

CPC classification number: C07C29/17 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/42 ,  C07C41/48 ,  C07C43/303 ,  C07C43/313 ,  C07C45/62 ,  C07C45/67 ,  C07C45/82 ,  C07D311/72 ,  C07D317/12 ,  C07D319/06 ,  C07C49/203 ,  C07C49/04 ,  C07C33/042 ,  C07C33/025

Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.

Abstract translation: 本发明涉及从（5E，9E） - ，（5E，9Z） - ，（5Z）的混合物在多步合成中制备（6R，10R）-6,10,14-三甲基十五烷-2-酮的方法 ，9E） - 和（5Z9Z）异构体，其中6,10,14-三甲基十五烷-5,9,13-三烯-2-酮或6,10,14-三甲基十五烷-5,9-二烯-2-酮 。 该方法非常有利，因为它以有效的方式形成来自起始产物的立体异构体的混合物的所需手性产物。