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公开(公告)号：US20150284337A1
公开(公告)日：2015-10-08
申请号：US14122199
申请日：2012-05-21
申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Nietz , Gary Probst
发明人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Nietz , Gary Probst
IPC分类号： C07D237/28 , C07D405/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D417/04 , C07D401/12 , C07D401/04
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式I结构的化合物：（I）或其盐或溶剂合物，其中R1，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US09884828B2
公开(公告)日：2018-02-06
申请号：US14122199
申请日：2012-05-21
申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
发明人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
IPC分类号： A61K31/502 , C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D417/04 , C07D413/10
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
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公开(公告)号：US08283358B2
公开(公告)日：2012-10-09
申请号：US12554134
申请日：2009-09-04
申请人： Andrei W. Konradi , Xiaocong Michael Ye , Simeon Bowers , Albert W. Garofalo , Danielle L. Aubele , Darren Dressen , Raymond Ng , Gary Probst , Christopher M. Semko , Minghua Sun , Anh P. Truong , Michael S. Dappen
发明人： Andrei W. Konradi , Xiaocong Michael Ye , Simeon Bowers , Albert W. Garofalo , Danielle L. Aubele , Darren Dressen , Raymond Ng , Gary Probst , Christopher M. Semko , Minghua Sun , Anh P. Truong , Michael S. Dappen
IPC分类号： A61K31/439 , C07D471/18
CPC分类号： C07D451/14 , C07D451/00
摘要： The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.
摘要翻译： 本发明提供具有式1,2,3和4结构的化合物：其中A环，B-环，C环，m，n，R25，R50和R51如说明书中所述 。 本发明还提供包含式1,2,3和4的化合物的药物组合物，以及治疗认知障碍如阿尔茨海默氏病的方法。 本发明还提供了可用于制备式1,2,3和4的化合物的中间体。
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公开(公告)号：US20100081680A1
公开(公告)日：2010-04-01
申请号：US12554134
申请日：2009-09-04
申请人： Andrei W. Konradi , Xiaocong Michael Ye , Simeon Bowers , Albert W. Garofalo , Danielle L. Aubele , Darren Dressen , Raymond Ng , Gary Probst , Christopher M. Semko , Minghua Sun , Anh P. Truong , Michael S. Dappen
发明人： Andrei W. Konradi , Xiaocong Michael Ye , Simeon Bowers , Albert W. Garofalo , Danielle L. Aubele , Darren Dressen , Raymond Ng , Gary Probst , Christopher M. Semko , Minghua Sun , Anh P. Truong , Michael S. Dappen
IPC分类号： A61K31/439 , C07D221/04 , C07D471/08 , A61K31/438 , A61P25/28
CPC分类号： C07D451/14 , C07D451/00
摘要： The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.
摘要翻译： 本发明提供具有式1,2,3和4结构的化合物：其中A环，B-环，C环，m，n，R25，R50和R51如说明书中所述 。 本发明还提供包含式1,2,3和4的化合物的药物组合物，以及治疗认知障碍如阿尔茨海默氏病的方法。 本发明还提供了可用于制备式1,2,3和4的化合物的中间体。
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公开(公告)号：US20120115848A1
公开(公告)日：2012-05-10
申请号：US13267834
申请日：2011-10-06
申请人： Robert A. Galemmo, JR. , Dean Richard Artis, I , Xiaocong Michael Ye , Danielle L. Aubele , Anh P. Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo, JR. , Dean Richard Artis, I , Xiaocong Michael Ye , Danielle L. Aubele , Anh P. Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/55 , C07D471/22 , C07D487/22 , C07D498/22 , A61K31/519 , A61P35/02 , A61K31/5377 , A61P25/00 , A61P25/16 , A61P25/28 , A61P35/00 , A61P35/04 , C07D487/14 , A61K31/5383
CPC分类号： C07D487/14 , C07D487/22 , C07D498/22
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，U1，U2，U3，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US08541418B2
公开(公告)日：2013-09-24
申请号：US12974622
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/4965 , C07D475/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，E1，E2，R 1，R 2，R 3和R 4在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US08445503B2
公开(公告)日：2013-05-21
申请号：US12974401
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A01N43/54 , A61K31/505 , C07D491/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US20110212942A1
公开(公告)日：2011-09-01
申请号：US12974401
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/55 , C07D475/00 , C07D471/14 , C07D487/14 , C07D498/14 , A61K31/4985 , A61K31/5383 , A61P35/00 , A61P25/28 , A61P25/16 , A61P35/02 , A61P35/04
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US20110207716A1
公开(公告)日：2011-08-25
申请号：US12974622
申请日：2010-12-21
申请人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
发明人： Robert A. Galemmo , Dean R. Artis , Xiaocong Michael Ye , Danielle Aubele , Anh Truong , Simeon Bowers , Roy K. Hom , Yong-Liang Zhu , R. Jeffrey Neitz , Jennifer Sealy , Marc Adler , Paul Beroza , John P. Anderson
IPC分类号： A61K31/519 , C07D475/00 , C07D475/12 , A61K31/5377 , A61K31/55 , A61K31/5383 , A61P25/28 , A61P25/16 , A61P35/00 , A61P35/04 , A61P35/02
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，E1，E2，R 1，R 2，R 3和R 4在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US20100267747A1
公开(公告)日：2010-10-21
申请号：US12796441
申请日：2010-06-08
申请人： Xiaocong Michael Ye , Albert W. Garofalo , Jacek J. Jagodzinski , Andrei W. Konradi , Christopher M. Semko , Jenifer L. Smith , Ying-zi Xu
发明人： Xiaocong Michael Ye , Albert W. Garofalo , Jacek J. Jagodzinski , Andrei W. Konradi , Christopher M. Semko , Jenifer L. Smith , Ying-zi Xu
IPC分类号： A61K31/506 , C07D471/04 , A61K31/437 , A61K31/4375 , A61P25/28
CPC分类号： C07D491/04 , C07D211/96 , C07D471/04
摘要： The invention provides N-cyclic sulfonamido compounds of Formula I wherein A, B, R1, R1a, R2, R2a, R3 and R3a are as described in the specification. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of preparing compounds of formula I, and methods of treating cognitive disorders, such as Alzheimer's disease.
摘要翻译： 本发明提供式I的N-环磺酰氨基化合物，其中A，B，R 1，R 1a，R 2，R 2a，R 3和R 3a如说明书中所述。 式I的化合物可用于治疗或预防认知障碍，例如阿尔茨海默病。 本发明还包括包含式I化合物，制备式I化合物的方法和治疗认知障碍如阿尔茨海默氏病的方法的药物组合物。
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