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公开(公告)号：US09884828B2
公开(公告)日：2018-02-06
申请号：US14122199
申请日：2012-05-21
申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
发明人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
IPC分类号： A61K31/502 , C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D417/04 , C07D413/10
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
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公开(公告)号：US20150284337A1
公开(公告)日：2015-10-08
申请号：US14122199
申请日：2012-05-21
申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Nietz , Gary Probst
发明人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Nietz , Gary Probst
IPC分类号： C07D237/28 , C07D405/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D417/04 , C07D401/12 , C07D401/04
CPC分类号： C07D237/28 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D417/04
摘要： The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译： 本发明提供具有式I结构的化合物：（I）或其盐或溶剂合物，其中R1，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。
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公开(公告)号：US06177562B1
公开(公告)日：2001-01-23
申请号：US09597979
申请日：2000-06-20
IPC分类号： C07D25702
CPC分类号： A61K49/06 , C07D257/02
摘要： Compounds of formulae (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
摘要翻译： 其中R，R 1，R 2，R 3和R 4基团具有本发明中定义的含义的式（I）和（II）化合物是用于金属离子的螯合剂。 化合物（I）和（II）与顺磁离子的配合物可用作M.R.I.的对比剂。 成像。
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公开(公告)号：US08076338B2
公开(公告)日：2011-12-13
申请号：US11568173
申请日：2005-04-22
申请人： Neel K. Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Lynne Canne Bannen , Diva Sze-Ming Chan , Baili Chen , Erick Wang Co , Simona Costanzo , Steven Charles Defina , Larisa Dubenko , Maurizio Franzini , Ping Huang , Vasu Jammalamadaka , Richard George Khoury , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Morrison B. Mac , John M. Nuss , Jason Jevious Parks , Kenneth D. Rice , Tsze H. Tsang , Amy Lew Tsuhako , Yong Wang , Wei Xu
发明人： Neel K. Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Lynne Canne Bannen , Diva Sze-Ming Chan , Baili Chen , Erick Wang Co , Simona Costanzo , Steven Charles Defina , Larisa Dubenko , Maurizio Franzini , Ping Huang , Vasu Jammalamadaka , Richard George Khoury , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Morrison B. Mac , John M. Nuss , Jason Jevious Parks , Kenneth D. Rice , Tsze H. Tsang , Amy Lew Tsuhako , Yong Wang , Wei Xu
IPC分类号： A61K31/501 , A61K31/497 , C07D473/16 , C07D401/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明涉及式（I）和（II）的化合物，其中R，R 21，R 25 -R 33，m，n，X 21-X 23和Q 1在本文中定义。 该化合物调节蛋白激酶酶活性以调节细胞活性，如增殖，分化，程序性细胞死亡，迁移和化学侵袭。 本发明的化合物抑制，调节和/或调节激酶，特别是p70S6和/或Akt激酶。 使用和制备化合物的方法及其药物组合物治疗激酶依赖性疾病和病症也是本发明的一个方面。
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公开(公告)号：US6149890A
公开(公告)日：2000-11-21
申请号：US61036
申请日：1998-04-16
IPC分类号： C07D401/06 , A61K49/00 , A61K49/06 , C07D257/02 , C07F5/00 , A61B5/055 , C07D225/00
CPC分类号： A61K49/06 , C07D257/02
摘要： Compounds of formulae (I) and (II) ##STR1## wherein the R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
摘要翻译： 其中R，R 1，R 2，R 3和R 4基团具有本发明中定义的含义的式（I）和（II）化合物是用于金属离子的螯合剂。 化合物（I）和（II）与顺磁离子的配合物可用作M.R.I.的对比剂。 成像。
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公开(公告)号：US20080076774A1
公开(公告)日：2008-03-27
申请号：US11568173
申请日：2005-04-22
申请人： Neel K. Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Lynne Canne Bannen , Diva Sze-Ming Chan , Baili Chen , Erick Wang Co , Simona Costanzo , Steven Charles Defina , Larisa Dubenko , Maurizio Franzini , Ping Huang , Vasu Jammalamadaka , Richard George Khoury , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Morrison B. Mac , John M. Nuss , Jason Jevious Parks , Kenneth D. Rice , Tsze H. Tsang , Amy Lew Tsuhako , Yong Wang , Wei Xu
发明人： Neel K. Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Lynne Canne Bannen , Diva Sze-Ming Chan , Baili Chen , Erick Wang Co , Simona Costanzo , Steven Charles Defina , Larisa Dubenko , Maurizio Franzini , Ping Huang , Vasu Jammalamadaka , Richard George Khoury , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Morrison B. Mac , John M. Nuss , Jason Jevious Parks , Kenneth D. Rice , Tsze H. Tsang , Amy Lew Tsuhako , Yong Wang , Wei Xu
IPC分类号： A61K31/497 , A61K31/501 , A61P43/00 , C07D403/14 , C07D473/00 , C12N5/06 , C12Q1/48
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明涉及式（I）和（II）的化合物，其中R 1，R 21，R 25，R 33，m ，n，X 21 -X 23和Q 1在本文中定义。 该化合物调节蛋白激酶酶活性以调节细胞活性，如增殖，分化，程序性细胞死亡，迁移和化学侵袭。 本发明的化合物抑制，调节和/或调节激酶，特别是p70S6和/或Akt激酶。 使用和制备化合物的方法及其药物组合物治疗激酶依赖性疾病和病症也是本发明的一个方面。
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公开(公告)号：US06509324B1
公开(公告)日：2003-01-21
申请号：US09913711
申请日：2001-09-24
申请人： Maurizio Franzini , Andrea Beltrami , Luisella Calabi , Alessandro Maiocchi , Mario Virtuani , Pier Lucio Anelli , Kondareddiar Ramalingam , Ramachandran S. Ranganathan
发明人： Maurizio Franzini , Andrea Beltrami , Luisella Calabi , Alessandro Maiocchi , Mario Virtuani , Pier Lucio Anelli , Kondareddiar Ramalingam , Ramachandran S. Ranganathan
IPC分类号： C07F928
CPC分类号： A61K49/10 , A61K49/0438 , A61K49/085 , A61K49/103 , C07F9/3808 , C07F9/5728 , C07J51/00 , Y10S977/93
摘要： Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
摘要翻译： 能够螯合双和三价顺磁性金属离子，它们与这些金属离子的螯合络合物及其生理相容的盐以及其中磁共振成像的化合物。
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公开(公告)号：US20110201599A1
公开(公告)日：2011-08-18
申请号：US13002195
申请日：2009-07-02
申请人： Suleyman Bahceci , Bryan Chan , Diva Sze-Ming Chan , Jeff Chen , Timothy Patrick Forsyth , Maurizio Franzini , Vasu Jammalamadaka , Joon Won Jeong , Lisa Renee Jones , Ryan Michael Kelley , Moon Hwan Kim , James W. Leahy , Morrison B. Mac , Robin Tammie Noguchi , Pallavi Rao , Brian Hugh Ridgway , Wei Xu , Yong Wang
发明人： Suleyman Bahceci , Bryan Chan , Diva Sze-Ming Chan , Jeff Chen , Timothy Patrick Forsyth , Maurizio Franzini , Vasu Jammalamadaka , Joon Won Jeong , Lisa Renee Jones , Ryan Michael Kelley , Moon Hwan Kim , James W. Leahy , Morrison B. Mac , Robin Tammie Noguchi , Pallavi Rao , Brian Hugh Ridgway , Wei Xu , Yong Wang
IPC分类号： A61K31/55 , C07D471/04 , C07D401/14 , C07D403/14 , C07D413/00 , C07D413/14 , C12N5/071 , A61K31/437 , A61K31/505 , A61K31/497 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P37/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： A compound according to Formula I: or a pharmaceutically-acceptable salt thereof, wherein R1, R3, A, B and D are as defined in the specification; pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 根据式I的化合物或其药学上可接受的盐，其中R 1，R 3，A，B和D如说明书中所定义; 其药物组合物及其使用方法。
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公开(公告)号：US20090247559A1
公开(公告)日：2009-10-01
申请号：US12341210
申请日：2008-12-22
申请人： S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
发明人： S. David Brown , Hongwang Du , Maurizio Franzini , Adam Antoni Galan , Ping Huang , Patrick Kearney , Moon Hwan Kim , Elena S. Koltun , Steven James Richards , Amy L. Tsuhako , Cristiana A. Zaharia
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00
CPC分类号： C07D491/04
摘要： A compound according to formula I: or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3a, R3b, R3c and R3d are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 根据式I的化合物或其药学上可接受的盐; 其中R1，R2，R3a，R3b，R3c和R3d如说明书中所定义，其药物组合物及其使用方法。
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公开(公告)号：USRE38329E1
公开(公告)日：2003-11-25
申请号：US10157462
申请日：2002-09-27
IPC分类号： A61B5055
CPC分类号： A61K49/06 , C07D257/02
摘要： Compounds of formula (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
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