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公开(公告)号：US11660592B2
公开(公告)日：2023-05-30
申请号：US17175287
申请日：2021-02-12
Applicant: DENOVIX, INC.
Inventor： Daniel A. Schieffer , David L. Ash , David B. Ward
IPC: B01L3/02
CPC classification number: B01L3/0224 , B01L3/0227 , B01L3/0237 , B01L3/0279 , B01L2400/049 , B01L2400/0478
Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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2.发明公开公开(公告)号：US20240066518A1
公开(公告)日：2024-02-29
申请号：US18239609
申请日：2023-08-29
Applicant: DeNovix Inc.
Inventor： Benayah Ben-Avraham , Daniel Schieffer , David L. Ash , Fernando Frederick Kielhorn , David B. Ward
IPC: B01L3/02
CPC classification number: B01L3/0227 , B01L3/0237
Abstract: Broad volumetric range pipettes with multi-tiered pipette tip holder and ejection assemblies and methods of using such pipettes are disclosed herein. These pipettes typically include a concentric cylinder arrangement with each outer cylinder configured for contacting and dislodging a pipette tip attached to the tip holder portion of the immediately adjacent inner cylinder. In this manner, different sized pipette tips can be used on a single device. In addition, a locking mechanism is described for locking the large tip holder into a downward position to minimize the extension of the small tip holder and thereby enabling attachment of large, filtered pipette tips and reducing/eliminating the risk that the liquid being transferred will contaminate the pipetting device.
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公开(公告)号：US11679383B2
公开(公告)日：2023-06-20
申请号：US17875235
申请日：2022-07-27
Applicant: DeNovix, INC.
Inventor： Daniel A. Schieffer , David L. Ash , David B. Ward
IPC: B01L3/02
CPC classification number: B01L3/0224 , B01L3/0227 , B01L3/0237 , B01L3/0279 , B01L2400/049 , B01L2400/0478
Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US10598598B2
公开(公告)日：2020-03-24
申请号：US16392030
申请日：2019-04-23
Applicant: Denovix, Inc.
Inventor： Fernando F. Kielhorn , Daniel A. Schieffer , David L. Ash , Kevin Kelley , Andrew William Jones
IPC: G01N21/64 , G01N21/03 , G01N15/14 , G01N33/487 , G02B21/06 , G06K9/00 , G06M11/02 , C12M1/34 , C12Q1/06
Abstract: Cell counters and methods of their use are disclosed herein. The cell counters include a sample mounting system that includes a base, which includes a mounted lower sample surface and a cover having a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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公开(公告)号：US20170370848A1
公开(公告)日：2017-12-28
申请号：US15628394
申请日：2017-06-20
Applicant: DeNovix, Inc.
Inventor： Fernando F. Kielhorn , Daniel A. Schieffer , David L. Ash , Kevin Kelley
CPC classification number: G01N21/6458 , G01N15/14 , G01N15/1434 , G01N15/1468 , G01N21/6456 , G01N33/487 , G01N2015/144 , G01N2015/1481 , G01N2021/035 , G01N2201/062 , G02B21/06 , G06K9/00127 , G06M11/02
Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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Patent Agency Ranking
公开(公告)号：US20160290866A1
公开(公告)日：2016-10-06
申请号：US15085520
申请日：2016-03-30
Applicant: DeNovix, Inc.
Inventor： Fernando F. Kielhorn , David B. Ward , David L. Ash
CPC classification number: G01J3/4406 , G01J3/0202 , G01J3/10 , G01J2001/242 , G01J2003/104 , G01J2003/106 , G01J2003/1213 , G01J2003/1221 , G01N21/255 , G01N21/645 , G01N2021/6419 , G01N2201/062
Abstract: An apparatus and method for measuring fluorescence of a sample is described. An apparatus includes three or more fluorescence channels passing through a sample site. The three or more fluorescence channels allow for exposing a sample at the sample site to light from three or more light sources, which results in fluorescence measurements based on emissions from the sample in response to the three or more light sources.
Abstract translation: 描述了用于测量样品的荧光的装置和方法。 一种装置包括通过样品位点的三个或更多个荧光通道。 三个或更多个荧光通道允许将样品位点处的样品暴露于来自三个或更多个光源的光，这导致基于来自样品的响应于三个或更多个光源的发射的荧光测量。
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公开(公告)号：US20220362759A1
公开(公告)日：2022-11-17
申请号：US17875235
申请日：2022-07-27
Applicant: DENOVIX, INC.
Inventor： Daniel A. Schieffer , David L. Ash , David B. Ward
IPC: B01L3/02
Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US20210252496A1
公开(公告)日：2021-08-19
申请号：US17175287
申请日：2021-02-12
Applicant: DENOVIX, INC.
Inventor： Daniel A. SCHIEFFER , David L. Ash , David B. Ward
IPC: B01L3/02
Abstract: Multivolume liquid pipettes with nested plunger and vacuum chamber configurations and methods of using such pipettes are disclosed herein. These pipettes typically include a body and a fluid displacement assembly with a small plunger element slideably received within a larger plunger element, each movable within a vacuum chamber for the precise and accurate control of the displacement of fluid, such as air. In turn, this allows for a single device to aspirate and dispense a broad range of liquids in a dynamic, accurate, and precise manner. In addition, the devices disclosed herein may also include a multi-tiered spring-loaded ejection mechanism to allow the user to use and eject pipette tips of different sizes.
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公开(公告)号：US20190310197A1
公开(公告)日：2019-10-10
申请号：US16392030
申请日：2019-04-23
Applicant: Denovix, Inc.
Inventor： Fernando F. Kielhorn , Daniel A. Schieffer , David L. Ash , Kevin Kelley , Andrew William Jones
IPC: G01N21/64 , G01N33/487 , G02B21/06 , G06K9/00 , G01N15/14
Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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公开(公告)号：US10302568B2
公开(公告)日：2019-05-28
申请号：US15628394
申请日：2017-06-20
Applicant: DeNovix, Inc.
Inventor： Fernando F. Kielhorn , Daniel A. Schieffer , David L. Ash , Kevin Kelley
IPC: G01N21/64 , G01N21/03 , G01N15/14 , G01N33/487 , G02B21/06 , G06M11/02 , C12M1/34 , C12Q1/06 , G06K9/00
Abstract: Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed.
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