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Patent Agency Ranking
公开(公告)号：US20200061495A1
公开(公告)日：2020-02-27
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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2.发明申请公开(公告)号：US20200172568A1
公开(公告)日：2020-06-04
申请号：US16610616
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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3.发明授权公开(公告)号：US11732003B2
公开(公告)日：2023-08-22
申请号：US16610616
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill
CPC classification number: C07K1/22 , A61L2/0088 , A61L2/26 , B01D15/245 , B01D15/361 , B01D15/3809 , B01L3/502 , C12N7/00 , A61L2202/21 , B01L2400/0481 , B01L2400/082 , C12N2740/10063 , C12N2740/10064 , C12N2795/00063 , C12N2795/00064
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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公开(公告)号：US20240042398A1
公开(公告)日：2024-02-08
申请号：US18552525
申请日：2022-04-14
Applicant: EMD Millipore Corporation
Inventor： Marisa Maher , Stefano Berti Perez , Anne Hansen , Noah Rhein , Amy Mei , Sualyneth Galarza , John Caulmare , Joseph W. Muldoon , Amy Wood
IPC: B01F23/231 , B01F35/513
CPC classification number: B01F23/231241 , B01F23/231151 , B01F23/23125 , B01F23/231264 , B01F35/513 , B01F2101/44
Abstract: A multi-layered flexible sparger (100) that has a bottom film layer (102), a middle film layer (106), and a top film layer (110); a first inner mesh (104) disposed between the bottom film layer and the middle film layer; a second inner mesh (114) disposed between the middle film layer and the top film layer; and a port capable of delivering a gas to the multi-layered flexible sparger disposed between the top film layer and the bottom film layer, wherein the middle film layer comprises drill holes and the top film layer comprises drill holes.
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公开(公告)号：US11547957B2
公开(公告)日：2023-01-10
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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