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公开(公告)号：US09920841B2
公开(公告)日：2018-03-20
申请号：US14646438
申请日：2013-12-16
发明人： John Saragosa , John Cieciuch , James E. Kelly , Luc Messier , Nicholas Vigorito
CPC分类号： F16K3/04 , G01N1/10 , G01N1/22 , G01N1/2226 , G01N2001/1037
摘要： A fluid transfer system (100) includes a transfer device (104) and an interface device (102). The transfer device (104) includes a fluid transfer member (164) and a transfer coupling member (125) to align the fluid transfer member (164) with the interface device (102). The interface device (102) includes a reservoir port (108), a fluid transfer member receptacle (144), an interface coupling member (124), and a reservoir valve (110). The interface coupling member (124) is configured to close the fluid transfer member receptacle (144) and to couple to the transfer coupling member (125) and open the fluid transfer member receptacle (144) to receive the fluid transfer member (164). The reservoir valve (110), e.g., a sliding seal, is configured to close the reservoir port (108) from the fluid transfer member receptacle (144) and to open the reservoir port (108) to the fluid transfer member (164) when the fluid transfer member (164) is positioned in the fluid transfer member receptacle (144). The fluid transfer member (164) can include a plunger assembly configured to open and close the reservoir port (108).
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2.发明申请公开(公告)号：US20200172568A1
公开(公告)日：2020-06-04
申请号：US16610616
申请日：2018-04-18
发明人： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill
摘要： Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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公开(公告)号：US20150276069A1
公开(公告)日：2015-10-01
申请号：US14646438
申请日：2013-12-16
发明人： John Saragosa , John Cieciuch , James E. Kelly , Luc Messier , Nicholas Vigorito
IPC分类号： F16K3/04
CPC分类号： F16K3/04 , G01N1/10 , G01N1/22 , G01N1/2226 , G01N2001/1037
摘要： A fluid transfer system (100) includes a transfer device (104) and an interface device (102). The transfer device (104) includes a fluid transfer member (164) and a transfer coupling member (125) to align the fluid transfer member (164) with the interface device (102). The interface device (102) includes a reservoir port (108), a fluid transfer member receptacle (144), an interface coupling member (124), and a reservoir valve (110). The interface coupling member (124) is configured to close the fluid transfer member receptacle (144) and to couple to the transfer coupling member (125) and open the fluid transfer member receptacle (144) to receive the fluid transfer member (164). The reservoir valve (110), e.g., a sliding seal, is configured to close the reservoir port (108) from the fluid transfer member receptacle (144) and to open the reservoir port (108) to the fluid transfer member (164) when the fluid transfer member (164) is positioned in the fluid transfer member receptacle (144). The fluid transfer member (164) can include a plunger assembly configured to open and close the reservoir port (108).
摘要翻译： 流体传输系统（100）包括传送装置（104）和接口装置（102）。 传送装置（104）包括流体传送构件（164）和传送联接构件（125），以使流体传送构件（164）与界面装置（102）对准。 接口装置（102）包括储存器端口（108），流体转移构件容器（144），界面连接构件（124）和储存器阀（110）。 接口联接构件（124）构造成关闭流体转移构件容器（144）并且联接到传递联接构件（125）并打开流体转移构件容器（144）以接收流体传递构件（164）。 储存器阀（110）（例如滑动密封件）构造成从流体转移构件接收器（144）关闭储存器端口（108）并且将储存器端口（108）打开到流体转移构件（164）时，当 流体传递构件（164）位于流体转移构件容器（144）中。 流体转移构件（164）可以包括构造成打开和关闭储存器端口（108）的柱塞组件。
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公开(公告)号：US11752470B2
公开(公告)日：2023-09-12
申请号：US16315069
申请日：2017-08-23
发明人： Songhua Liu , Michael Lynch , Ryan Sylvia , Joseph Almasian , Salvatore Giglia , Luc Messier
CPC分类号： B01D63/14 , B01D46/00 , B01D46/04 , B01D46/522 , B01D2201/122 , B01D2313/20
摘要： A scaling tool for replicating filtration characteristics of a large-scale filtration device, the scaling tool comprising a housing having a fluid inlet and a fluid outlet, and a filter receiving region in fluid communication with the fluid inlet and the fluid outlet and configured to contain a membrane comprising one or more pleats, the filter receiving region being defined by a rigid wall framework configured to hold the one or more pleats of the membrane and compress the pleats in an amount effective to replicate the filtration performance of the large-scale filtration device. Also disclosed is a methodology for configuring a filter receiving region in a scaling tool.
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5.发明授权公开(公告)号：US11732003B2
公开(公告)日：2023-08-22
申请号：US16610616
申请日：2018-04-18
发明人： Ronald Tuccelli , John Caulmare , Luc Messier , Melissa Holstein , Christopher Gillespie , Roger Hill
CPC分类号： C07K1/22 , A61L2/0088 , A61L2/26 , B01D15/245 , B01D15/361 , B01D15/3809 , B01L3/502 , C12N7/00 , A61L2202/21 , B01L2400/0481 , B01L2400/082 , C12N2740/10063 , C12N2740/10064 , C12N2795/00063 , C12N2795/00064
摘要： Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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公开(公告)号：US20190224626A1
公开(公告)日：2019-07-25
申请号：US16315069
申请日：2017-08-23
发明人： Songhua Liu , Michael Lynch , Ryan Sylvia , Joseph Almasian , Salvatore Giglia , Luc Messier
摘要： A scaling tool for replicating filtration characteristics of a large-scale filtration device, the scaling tool comprising a housing having a fluid inlet and a fluid outlet, and a filter receiving region in fluid communication with the fluid inlet and the fluid outlet and configured to contain a membrane comprising one or more pleats, the filter receiving region being defined by a rigid wall framework configured to hold the one or more pleats of the membrane and compress the pleats in an amount effective to replicate the filtration performance of the large-scale filtration device. Also disclosed is a methodology for configuring a filter receiving region in a scaling tool.
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