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公开(公告)号：US09586990B2
公开(公告)日：2017-03-07
申请号：US14434219
申请日：2013-10-04
Applicant: Erber Aktiengesellschaft
Inventor： Gerd Schatzmayr , Eva-Maria Binder , Michaela Thamhesl , Dieter Moll
CPC classification number: C07K5/0806 , A23K10/14 , C12N9/14 , C12N9/52 , C12P17/183 , Y02P20/52
Abstract: Enzymes for transforming, in particular hydrolytically cleaving, ergopeptines, which ergopeptines are α/β-hydrolases hydrolytically cleaving ergopeptines in the cyclol ring, for the transformation of ergopeptines, and method for producing ergopeptine-metabolizing enzymes.
Abstract translation: 用于转化，特别是水解切割的麦角霉素，其中奥匹他霉素是环环中的α/β-水解酶水解切割蛋白多肽，用于转化ergopeptine，以及用于生产ergopeptine代谢酶的方法。
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公开(公告)号：US11324235B2
公开(公告)日：2022-05-10
申请号：US16934179
申请日：2020-07-21
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US20200375218A1
公开(公告)日：2020-12-03
申请号：US16934179
申请日：2020-07-21
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US11998027B2
公开(公告)日：2024-06-04
申请号：US17829416
申请日：2022-06-01
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC classification number: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , C12N9/14 , C12N9/18 , C12Y301/01 , A23V2002/00 , Y02A40/818
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US11910807B2
公开(公告)日：2024-02-27
申请号：US17555731
申请日：2021-12-20
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC classification number: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , C12N9/14 , C12N9/18 , C12Y301/01 , A23V2002/00 , Y02A40/818
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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Patent Agency Ranking
公开(公告)号：US20210371835A1
公开(公告)日：2021-12-02
申请号：US17264096
申请日：2019-07-30
Applicant: ERBER AKTIENGESELLSCHAFT
Inventor： Michaela Thamhesl , Sebastian Fruhauf , Wulf-Dieter Moll , Andreas Hoebartner , Gerd Schatzmayr , Eva Maria Binder , Markus Aleschko , Martin Pfeffer
IPC: C12N9/14 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , A23L29/00 , A23L33/10 , A23L33/00 , A61K38/46
Abstract: The present invention relates to a method for increasing the stability of an α/β-hydrolase. In addition, the present invention relates to an α/β-hydrolase obtainable by the method of the present invention. Also provided are α/β-hydrolases having a decreased grand average of hydropathy (GRAVY) value and/or comprising specific mutations. In addition, the present invention concerns a use of an α/β-hydrolase of the present invention for degrading zearalenone (ZEN).
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公开(公告)号：US10779556B2
公开(公告)日：2020-09-22
申请号：US16161266
申请日：2018-10-16
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
IPC: A23K10/14 , C12N9/14 , A23K50/75 , A23K50/30 , A23K50/80 , A23L3/3571 , C12N9/18 , C07K14/195
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US10076125B2
公开(公告)日：2018-09-18
申请号：US15054232
申请日：2016-02-26
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC classification number: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , A23V2002/00 , C12N9/14 , C12N9/18 , C12Y301/01 , Y02A40/818
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US11998028B2
公开(公告)日：2024-06-04
申请号：US17829431
申请日：2022-06-01
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC classification number: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , C12N9/14 , C12N9/18 , C12Y301/01 , A23V2002/00 , Y02A40/818
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US20220287328A1
公开(公告)日：2022-09-15
申请号：US17829431
申请日：2022-06-01
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian FRUHAUF , Michaela Thamhesl , Martin Pfeffer , Dleter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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