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公开(公告)号:US20220002806A1
公开(公告)日:2022-01-06
申请号:US17311210
申请日:2019-12-06
IPC分类号: C12Q1/6883 , G01N33/50 , C12Q1/02
摘要: The present invention relates to a novel method for detecting zearalenone (ZEN) effect comprising determining the expression level of at least one miRNA in a test sample, as well as to a novel use of at least one miRNA for detecting zearalenone (ZEN) effect in a test sample.
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公开(公告)号:US09586990B2
公开(公告)日:2017-03-07
申请号:US14434219
申请日:2013-10-04
CPC分类号: C07K5/0806 , A23K10/14 , C12N9/14 , C12N9/52 , C12P17/183 , Y02P20/52
摘要: Enzymes for transforming, in particular hydrolytically cleaving, ergopeptines, which ergopeptines are α/β-hydrolases hydrolytically cleaving ergopeptines in the cyclol ring, for the transformation of ergopeptines, and method for producing ergopeptine-metabolizing enzymes.
摘要翻译: 用于转化,特别是水解切割的麦角霉素,其中奥匹他霉素是环环中的α/β-水解酶水解切割蛋白多肽,用于转化ergopeptine,以及用于生产ergopeptine代谢酶的方法。
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公开(公告)号:US11324235B2
公开(公告)日:2022-05-10
申请号:US16934179
申请日:2020-07-21
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US11096980B2
公开(公告)日:2021-08-24
申请号:US16473643
申请日:2017-12-14
发明人: Elisabeth Mayer , Barbara Novak , Christina Schwab-Andics , Ursula Hofstätter-Schaehs , Gerd Schatzmayr
IPC分类号: A61K36/484 , A23K20/163 , A23K10/30 , A61K31/704 , A23K50/30 , A23K50/75 , A61K9/00
摘要: A method of using at least one Glycyrrhiza plant preparation selected from the group of flour of a whole, dried Glycyrrhiza plant, flour of the leaves of the dried Glycyrrhiza plant, flour of roots of the dried Glycyrrhiza plant, aqueous dry extract of the Glycyrrhiza plant, aqueous/ethanolic dry extract of the Glycyrrhiza plant, aqueous extract of the Glycyrrhiza plant, optionally together with at least one excipient, for reducing the toxic effect of at least one polypeptide fungitoxin in agrarian products.
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公开(公告)号:US20200375218A1
公开(公告)日:2020-12-03
申请号:US16934179
申请日:2020-07-21
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US20210371835A1
公开(公告)日:2021-12-02
申请号:US17264096
申请日:2019-07-30
发明人: Michaela Thamhesl , Sebastian Fruhauf , Wulf-Dieter Moll , Andreas Hoebartner , Gerd Schatzmayr , Eva Maria Binder , Markus Aleschko , Martin Pfeffer
IPC分类号: C12N9/14 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , A23L29/00 , A23L33/10 , A23L33/00 , A61K38/46
摘要: The present invention relates to a method for increasing the stability of an α/β-hydrolase. In addition, the present invention relates to an α/β-hydrolase obtainable by the method of the present invention. Also provided are α/β-hydrolases having a decreased grand average of hydropathy (GRAVY) value and/or comprising specific mutations. In addition, the present invention concerns a use of an α/β-hydrolase of the present invention for degrading zearalenone (ZEN).
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公开(公告)号:US20200338138A1
公开(公告)日:2020-10-29
申请号:US16955706
申请日:2018-12-19
IPC分类号: A61K35/741 , C12P7/42 , A23K10/18 , A23K50/30 , A23K50/60
摘要: The present invention relates to a use of a microorganism of the class Coriobacteriia for promoting gut health of a healthy subject. Also provided is a method for the production of chenodeoxycholic acid (CDCA) and a method for the production of lithocholic acid (LCA).
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公开(公告)号:US10779556B2
公开(公告)日:2020-09-22
申请号:US16161266
申请日:2018-10-16
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
IPC分类号: A23K10/14 , C12N9/14 , A23K50/75 , A23K50/30 , A23K50/80 , A23L3/3571 , C12N9/18 , C07K14/195
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US10076125B2
公开(公告)日:2018-09-18
申请号:US15054232
申请日:2016-02-26
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC分类号: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , A23V2002/00 , C12N9/14 , C12N9/18 , C12Y301/01 , Y02A40/818
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US20220287328A1
公开(公告)日:2022-09-15
申请号:US17829431
申请日:2022-06-01
发明人: Sebastian FRUHAUF , Michaela Thamhesl , Martin Pfeffer , Dleter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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