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公开(公告)号：US09586990B2
公开(公告)日：2017-03-07
申请号：US14434219
申请日：2013-10-04
Applicant: Erber Aktiengesellschaft
Inventor： Gerd Schatzmayr , Eva-Maria Binder , Michaela Thamhesl , Dieter Moll
CPC classification number: C07K5/0806 , A23K10/14 , C12N9/14 , C12N9/52 , C12P17/183 , Y02P20/52
Abstract: Enzymes for transforming, in particular hydrolytically cleaving, ergopeptines, which ergopeptines are α/β-hydrolases hydrolytically cleaving ergopeptines in the cyclol ring, for the transformation of ergopeptines, and method for producing ergopeptine-metabolizing enzymes.
Abstract translation: 用于转化，特别是水解切割的麦角霉素，其中奥匹他霉素是环环中的α/β-水解酶水解切割蛋白多肽，用于转化ergopeptine，以及用于生产ergopeptine代谢酶的方法。
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公开(公告)号：US11998027B2
公开(公告)日：2024-06-04
申请号：US17829416
申请日：2022-06-01
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC classification number: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , C12N9/14 , C12N9/18 , C12Y301/01 , A23V2002/00 , Y02A40/818
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US11910807B2
公开(公告)日：2024-02-27
申请号：US17555731
申请日：2021-12-20
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC classification number: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , C12N9/14 , C12N9/18 , C12Y301/01 , A23V2002/00 , Y02A40/818
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US20220002806A1
公开(公告)日：2022-01-06
申请号：US17311210
申请日：2019-12-06
Applicant: ERBER AKTIENGESELLSCHAFT
Inventor： Bertrand Grenier , Veronika Nagl , Gerd Schatzmayr , Eva-Maria Binder
IPC: C12Q1/6883 , G01N33/50 , C12Q1/02
Abstract: The present invention relates to a novel method for detecting zearalenone (ZEN) effect comprising determining the expression level of at least one miRNA in a test sample, as well as to a novel use of at least one miRNA for detecting zearalenone (ZEN) effect in a test sample.
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公开(公告)号：US11324235B2
公开(公告)日：2022-05-10
申请号：US16934179
申请日：2020-07-21
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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Patent Agency Ranking
6.发明授权公开(公告)号：US11096980B2
公开(公告)日：2021-08-24
申请号：US16473643
申请日：2017-12-14
Applicant: Erber Aktiengesellschaft
Inventor： Elisabeth Mayer , Barbara Novak , Christina Schwab-Andics , Ursula Hofstätter-Schaehs , Gerd Schatzmayr
IPC: A61K36/484 , A23K20/163 , A23K10/30 , A61K31/704 , A23K50/30 , A23K50/75 , A61K9/00
Abstract: A method of using at least one Glycyrrhiza plant preparation selected from the group of flour of a whole, dried Glycyrrhiza plant, flour of the leaves of the dried Glycyrrhiza plant, flour of roots of the dried Glycyrrhiza plant, aqueous dry extract of the Glycyrrhiza plant, aqueous/ethanolic dry extract of the Glycyrrhiza plant, aqueous extract of the Glycyrrhiza plant, optionally together with at least one excipient, for reducing the toxic effect of at least one polypeptide fungitoxin in agrarian products.
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公开(公告)号：US20200375218A1
公开(公告)日：2020-12-03
申请号：US16934179
申请日：2020-07-21
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号：US20210371835A1
公开(公告)日：2021-12-02
申请号：US17264096
申请日：2019-07-30
Applicant: ERBER AKTIENGESELLSCHAFT
Inventor： Michaela Thamhesl , Sebastian Fruhauf , Wulf-Dieter Moll , Andreas Hoebartner , Gerd Schatzmayr , Eva Maria Binder , Markus Aleschko , Martin Pfeffer
IPC: C12N9/14 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , A23L29/00 , A23L33/10 , A23L33/00 , A61K38/46
Abstract: The present invention relates to a method for increasing the stability of an α/β-hydrolase. In addition, the present invention relates to an α/β-hydrolase obtainable by the method of the present invention. Also provided are α/β-hydrolases having a decreased grand average of hydropathy (GRAVY) value and/or comprising specific mutations. In addition, the present invention concerns a use of an α/β-hydrolase of the present invention for degrading zearalenone (ZEN).
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公开(公告)号：US20200338138A1
公开(公告)日：2020-10-29
申请号：US16955706
申请日：2018-12-19
Applicant: ERBER AKTIENGESELLSCHAFT
Inventor： Dian Schatzmayr , Eva Maria Binder , Veronika Nagl , Gerd Schatzmayr
IPC: A61K35/741 , C12P7/42 , A23K10/18 , A23K50/30 , A23K50/60
Abstract: The present invention relates to a use of a microorganism of the class Coriobacteriia for promoting gut health of a healthy subject. Also provided is a method for the production of chenodeoxycholic acid (CDCA) and a method for the production of lithocholic acid (LCA).
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公开(公告)号：US10779556B2
公开(公告)日：2020-09-22
申请号：US16161266
申请日：2018-10-16
Applicant: Erber Aktiengesellschaft
Inventor： Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
IPC: A23K10/14 , C12N9/14 , A23K50/75 , A23K50/30 , A23K50/80 , A23L3/3571 , C12N9/18 , C07K14/195
Abstract: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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