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公开(公告)号：US20070065815A1
公开(公告)日：2007-03-22
申请号：US11515854
申请日：2006-09-05
申请人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Brow , Todd Anderson , James Dahlberg
发明人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Brow , Todd Anderson , James Dahlberg
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US20050014163A1
公开(公告)日：2005-01-20
申请号：US10655362
申请日：2003-09-04
申请人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Ann Brow , Todd Anderson , James Dahlberg
发明人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Ann Brow , Todd Anderson , James Dahlberg
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US20060110750A1
公开(公告)日：2006-05-25
申请号：US11222565
申请日：2005-09-09
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20060177835A1
公开(公告)日：2006-08-10
申请号：US11183078
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20060040294A1
公开(公告)日：2006-02-23
申请号：US11183211
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20050181435A1
公开(公告)日：2005-08-18
申请号：US11103943
申请日：2005-04-12
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
IPC分类号： G01N33/50 , C12N1/21 , C12N9/12 , C12N9/16 , C12N9/22 , C12N15/09 , C12Q1/68 , G01N33/566 , C07H21/04
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及在靶序列上形成核酸切割结构并以位点特异性方式切割核酸切割结构的方法。 使用各种酶的结构特异性核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20070292856A1
公开(公告)日：2007-12-20
申请号：US11489665
申请日：2006-07-19
申请人： Victor Lyamichev , Michael Kaiser , Natalie Lyamichev , Jeff Hall , James Prudent , Mary Brow
发明人： Victor Lyamichev , Michael Kaiser , Natalie Lyamichev , Jeff Hall , James Prudent , Mary Brow
IPC分类号： C12Q1/68
CPC分类号： C12N9/22 , C12Q1/6813 , C12Q2521/301
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20050130179A1
公开(公告)日：2005-06-16
申请号：US10875094
申请日：2004-06-23
申请人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim Allawi , Sarah Wayland , Tsetska Takova , Bruce Neri , James Prudent , Jeff Hall
发明人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim Allawi , Sarah Wayland , Tsetska Takova , Bruce Neri , James Prudent , Jeff Hall
IPC分类号： G01N33/50 , C07F9/24 , C07F9/59 , C12N9/22 , C12N15/09 , C12Q1/68 , G01N27/447 , G01N33/58 , C07H21/04
CPC分类号： C12N9/22 , C07F9/2408 , C07F9/59 , C12Q1/6816 , C12Q1/6823 , C12Q1/683 , C12Q2525/197 , C12Q2565/125 , C12Q2563/107
摘要： The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.
摘要翻译： 本发明涉及新型亚磷酰胺，包括正中和中性化合物。 本发明还提供用于附着到包括固体支持物和核酸的材料的电荷标签，其中电荷标签增加或减少材料的净电荷。 本发明还提供了基于修饰材料和未改性材料之间的电荷差异分离和表征分子的方法。
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公开(公告)号：US20070003942A1
公开(公告)日：2007-01-04
申请号：US11183077
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Ann Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Ann Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及在靶序列上形成核酸切割结构并以位点特异性方式切割核酸切割结构的方法。 使用各种酶的结构特异性核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20060292580A1
公开(公告)日：2006-12-28
申请号：US11183015
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Ann Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Ann Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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