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公开(公告)号:US20050158716A1
公开(公告)日:2005-07-21
申请号:US10409594
申请日:2003-04-08
申请人: James Dahlberg , Mary Brow , Victor Lyamichev
发明人: James Dahlberg , Mary Brow , Victor Lyamichev
IPC分类号: C07H21/00 , C07K14/47 , C07K14/82 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/68 , C12P19/34
CPC分类号: C12Q1/6886 , C07H21/00 , C07K14/4746 , C07K14/82 , C12N9/1252 , C12N15/10 , C12N15/113 , C12Q1/682 , C12Q1/6823 , C12Q1/683 , C12Q1/689 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
摘要翻译: 本发明涉及以位点特异性方式切割核酸切割结构的方法。 酶包括5'核酸酶和3'核酸外切酶,用于检测和鉴定衍生自微生物的核酸。 提供了允许在样品中检测和鉴定细菌和病毒病原体的方法。
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公开(公告)号:US20050105349A1
公开(公告)日:2005-05-19
申请号:US10699932
申请日:2003-11-04
申请人: James Dahlberg , Obed Duardo
发明人: James Dahlberg , Obed Duardo
CPC分类号: G11C7/1078 , G11C7/1093 , G11C7/222
摘要: A double data rate (DDR) synchronous dynamic RAM (SDRAM), or DDR-SDRAM, memory controller employing a delay locked loop (DLL) circuit to delay an SDRAM data strobe (DQS) signal to the center, or ‘eye’ of the read data window. However, in distinction from conventional techniques, the initial delay determined by the DLL is fine tuned with an offset determined by a memory test. Moreover, in an additional embodiment, the delay may be further adjusted during operation to compensate for environmental conditions by a PVT (process, value, temperature) circuit.
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公开(公告)号:US20050074788A1
公开(公告)日:2005-04-07
申请号:US10740256
申请日:2003-12-18
申请人: James Dahlberg , Hatim Allawi , Victor Lyamichev , Bruce Neri , Marilyn Olson-Munoz , LuAnne Chehak , Sarah Olson
发明人: James Dahlberg , Hatim Allawi , Victor Lyamichev , Bruce Neri , Marilyn Olson-Munoz , LuAnne Chehak , Sarah Olson
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6816 , C12Q2565/1015 , C12Q2561/109 , C12Q2525/207
摘要: The present invention relates to compositions and methods for the detection and characterization of interfering RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs) and other short nucleic acid molecules. More particularly, the present invention relates to improved methods for the detection and quantitation of interfering RNA expression. The present invention further provides for the detection of variants and types of miRNAs and siRNAs.
摘要翻译: 本发明涉及用于检测和表征干扰RNA如微RNA(miRNA)和小干扰RNA(siRNA)和其他短核酸分子的组合物和方法。 更具体地,本发明涉及用于检测和定量干扰RNA表达的改进方法。 本发明还提供了miRNA和siRNA的变体和类型的检测。
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公开(公告)号:US20060110750A1
公开(公告)日:2006-05-25
申请号:US11222565
申请日:2005-09-09
申请人: James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人: James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号: C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号:US20060066980A1
公开(公告)日:2006-03-30
申请号:US10955713
申请日:2004-09-30
申请人: Jason Brenden , James Dahlberg
发明人: Jason Brenden , James Dahlberg
IPC分类号: G11B21/02
摘要: A control apparatus controls retraction of a device carried on a moveable member actuated by an electric motor after a sudden power loss. The control apparatus includes a measuring circuit for measuring a back electromotive force (back EMF) from the electric motor during a measuring phase. The control apparatus also includes a controller which receives the actual velocity and provides a command signal for controlling a magnitude of the drive current based on a commanded velocity and the actual velocity of the moveable member. The control apparatus further comprises a current control loop for providing a command current signal based on the current provided to the electric motor and the command signal, and for providing the electric motor with the drive current during a driving phase based on the command current signal.
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公开(公告)号:US20060040299A1
公开(公告)日:2006-02-23
申请号:US11198657
申请日:2005-08-05
申请人: James Dahlberg , Mary Ann Brow , Victor Lyamichev
发明人: James Dahlberg , Mary Ann Brow , Victor Lyamichev
CPC分类号: C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号:US20060035257A1
公开(公告)日:2006-02-16
申请号:US11198794
申请日:2005-08-05
申请人: James Dahlberg , Mary Brow , Victor Lyamichev
发明人: James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号: C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号:US20060007581A1
公开(公告)日:2006-01-12
申请号:US10955543
申请日:2004-09-30
申请人: Jason Brenden , James Dahlberg
发明人: Jason Brenden , James Dahlberg
IPC分类号: G11B21/02
摘要: A disk drive emergency retract architecture for providing power to a voice coil motor (VCM) to retract a transducing head from a surface of a recordable medium during loss of power from an external power supply. The disk drive emergency retract architecture comprises a spindle motor, having an internal inductance and an internal resistance, for spinning the recordable medium. The spinning recordable medium creates a back electromotive force (BEMF) in the spindle motor. A boost circuit transfers the back electromotive force located in the spindle motor to a capacitor which stores and supplies power to the VCM. The capacitor is connected to a power switch circuit, which supplies power from the capacitor to the VCM when the power switch circuit is in a conducting state and prevents power from being supplied to by the capacitor to the VCM when the power switch circuit is in a non-conducting state. A retract circuit supplies a signal to the power switch circuit, dictating whether the power switch circuit is in the conducting state or the non-conducting state. The retract circuit operates to alternate the power switch circuit between the conducting state and the non-conducting state at a set frequency, resulting in power being provided from the capacitor to the VCM at this frequency.
摘要翻译: 一种用于向音圈电机(VCM)提供电力的磁盘驱动器紧急缩回架构,以在从外部电源断电时从可记录介质的表面缩回换能头。 磁盘驱动器紧急撤回架构包括具有用于旋转可记录介质的内部电感和内部电阻的主轴电动机。 纺纱可记录介质在主轴电机中产生反电动势(BEMF)。 升压电路将位于主轴电动机中的反电动势传递到向VCM存储和供应电力的电容器。 电容器连接到电源开关电路,当电源开关电路处于导通状态时,该电源开关电路从电容器向VCM供电,并且当功率开关电路处于导通状态时,电容器被连接到电容器向VCM供电 非导电状态。 撤回电路向功率开关电路提供信号,指示电源开关电路是否处于导通状态或非导通状态。 缩回电路操作以在设定频率的导通状态和非导通状态之间交替电源开关电路,导致在该频率下从电容器向VCM提供功率。
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公开(公告)号:US20060183109A1
公开(公告)日:2006-08-17
申请号:US11198675
申请日:2005-08-05
申请人: James Dahlberg , Mary Brow , Victor Lyamichev
发明人: James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号: C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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10.
公开(公告)号:US20060066981A1
公开(公告)日:2006-03-30
申请号:US10955714
申请日:2004-09-30
申请人: Jason Brenden , James Dahlberg
发明人: Jason Brenden , James Dahlberg
IPC分类号: G11B21/02
摘要: A control circuit controls current through a voice coil motor (VCM) during retraction of a transducing head from the surface of a recordable medium. The transducing head is carried on movable member actuated by the VCM. The control circuit includes a measuring circuit for measuring a back electromotive force (back EMF) from the VCM. The control circuit also includes a driver circuit connected to terminals of the VCM for providing the VCM with a drive current having a magnitude based on the back EMF from the VCM. The control circuit further includes a chop clock to alternate between measuring the back EMF from the VCM and providing the VCM with the drive current at a random frequency within a range of frequencies around a median frequency.
摘要翻译: 控制电路在从可记录介质的表面回缩换能头时控制通过音圈电机(VCM)的电流。 传感头承载在由VCM致动的可移动部件上。 控制电路包括用于测量来自VCM的反电动势(反电动势)的测量电路。 控制电路还包括连接到VCM的端子的驱动器电路,用于向VCM提供具有基于来自VCM的反电动势的幅度的驱动电流。 控制电路还包括一个斩波时钟,用于在从VCM测量反电动势之间交替,并在围绕中间频率的频率范围内以随机频率提供驱动电流。
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