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    Cavity-filling biopsy site markers
    1.
    发明授权
    Cavity-filling biopsy site markers 有权
    腔填充活检部位标记

    公开(公告)号：US08626270B2

    公开(公告)日：2014-01-07

    申请号：US13495408

    申请日：2012-06-13

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    IPC分类号： A61B8/00 ,  A61B8/14 ,  A61B8/08 ,  A61B8/12

    CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

    摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

    摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

    Marker or filler forming fluid
    2.
    发明授权
    Marker or filler forming fluid 有权
    标记或填料成型液

    公开(公告)号：US08447386B2

    公开(公告)日：2013-05-21

    申请号：US12967639

    申请日：2010-12-14

    申请人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    发明人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

    IPC分类号： A61B6/00 ,  A61B10/00

    CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/226

    摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.

    摘要翻译： 一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被构造成排出标记物质的机构的室。 标记物质的量被容纳在标记物输送装置的室内。 标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。 输送管与标记物递送装置的腔室流体连通地联接。 输送管具有远端，其具有排出口，排出标记物质。 可释放的可远程检测的远侧末端联接到输送管的远端，并且构造成在其形成时被释放以保持在腔内的多孔生物可吸收体内。

    Imageable biopsy site marker
    3.
    发明申请
    Imageable biopsy site marker 审中-公开
    可成像的活检部位标记

    公开(公告)号：US20090131825A1

    公开(公告)日：2009-05-21

    申请号：US12317100

    申请日：2008-12-18

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

    IPC分类号： A61B17/34

    CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

    摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by a delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

    摘要翻译： 活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。 具有不透射线物体的至少一个生物可吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。 将管的一端放入活检部位。 至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。 至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像 导入后的第二时间点（如5-7个月）附近的组织组织。

    Cavity-filling biopsy site markers
    6.
    发明授权
    Cavity-filling biopsy site markers 有权
    腔填充活检部位标记

    公开(公告)号：US06862470B2

    公开(公告)日：2005-03-01

    申请号：US10124757

    申请日：2002-04-16

    申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

    IPC分类号： A61B6/00 ,  A61B6/12 ,  A61B8/08 ,  A61B8/12 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B19/00 ,  A61K49/00 ,  A61K49/04 ,  A61K49/22

    CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

    摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

    摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

    Sentinel node location and biopsy
    8.
    发明授权
    Sentinel node location and biopsy 有权
    前哨淋巴结位置和活检

    公开(公告)号：US06638234B2

    公开(公告)日：2003-10-28

    申请号：US09727112

    申请日：2000-11-29

    申请人： Fred H. Burbank ,  Paul Lubock

    发明人： Fred H. Burbank ,  Paul Lubock

    IPC分类号： A61B1000

    CPC分类号： A61B10/0266 ,  A61B6/4258 ,  A61B10/02 ,  A61B17/00491 ,  A61B18/1477 ,  A61B18/1482 ,  A61B18/1487 ,  A61B18/1815 ,  A61B90/39 ,  A61B2010/0208 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00273 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00916 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3908 ,  A61B2090/392

    摘要： A method and apparatus for locating and accessing a patient's sentinel lymph nodes which are associated with a lesion site of the patient. A radiopharmaceutical is injected at or near a lesion site within a patient's body. The migration of the radiopharmaceutical and accumulation of the radiopharmaceutical in a sentinel node of the patient is monitored with a gamma camera or radiation energy detector from outside the patient's body. The sentinel node can then be accessed with a cannula having an RF energy electrode on the distal end of the cannula which is activated during insertion of the cannula. Once the distal end of the cannula is positioned adjacent the sentinel node, an anchor device is inserted through the cannula. The distal end of the anchor device is then positioned in the sentinel node and secured to the sentinel node to be used as a locator for subsequent procedures.

    摘要翻译： 一种用于定位和访问与患者的病变部位相关联的患者前哨淋巴结的方法和装置。 在患者体内的病变部位处或附近注射放射性药物。 放射性药物的迁移和放射性药物的积聚在患者的前哨淋巴结中用伽马照相机或辐射能量检测器从患者身体外部监测。 然后可以使用在插管的远端处具有RF能量电极的插管来访问前哨节点，其在插管期间被激活。 一旦套管的远端定位成邻近前哨节点，锚定装置就插入插管中。 然后将锚装置的远端定位在前哨节点中并固定到前哨节点，以用作后续步骤的定位器。