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1.发明申请Infectious cDNA of an approved vaccine strain of measles virus, use for immunogenic compositions 有权经证实的麻疹病毒疫苗株的感染性cDNA，用于免疫原性组合物公开(公告)号：US20050227224A1
公开(公告)日：2005-10-13
申请号：US11013786
申请日：2004-12-17
IPC分类号： A61K39/165 , C07K14/12 , C12N7/00 , C12N15/45 , C12N15/63 , C12N15/86 , C12Q1/70 , C07H21/04
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2795/10243
摘要： The invention relates to a cDNA molecule which encodes the nucleotide sequence of the full length antigenomic (+)RNA strand of a measles virus (MV) originating from an approved vaccine strain. It also concerns the preparation of immunogenic compositions using said cDNA.
摘要翻译： 本发明涉及一种cDNA分子，其编码源自经批准的疫苗株的麻疹病毒（MV）的全长基因组（+）RNA链的核苷酸序列。 它还涉及使用所述cDNA制备免疫原性组合物。
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2.发明授权公开(公告)号：US09701944B2
公开(公告)日：2017-07-11
申请号：US14667088
申请日：2015-03-24
IPC分类号： C07K14/005 , C12N15/86 , C12N7/00 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2795/10243
摘要： The invention relates to a cDNA molecule which encodes the nucleotide sequence of the full length antigenomic (+)RNA strand of a measles virus (MV) originating from an approved vaccine strain. It also concerns the preparation of immunogenic compositions using said cDNA.
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3.发明申请公开(公告)号：US20130296541A1
公开(公告)日：2013-11-07
申请号：US12219570
申请日：2008-07-24
IPC分类号： C07H21/04
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2795/10243
摘要： The invention relates to a cDNA molecule which encodes the nucleotide sequence of the full length antigenomic (+)RNA strand of a measles virus (MV) originating from an approved vaccine strain. It also contains the preparation of immunogenic compositions using said cDNA.
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4.发明授权Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae infection 有权嵌合多肽及其针对黄病毒科感染的治疗用途公开(公告)号：US08337857B2
公开(公告)日：2012-12-25
申请号：US11917907
申请日：2006-06-20
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： A61K39/00 , A61K39/295 , A61K39/193
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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5.发明申请CHIMERIC POLY PEPTIDES AND THE THERAPEUTIC USE THEREOF AGAINST A FLAVIVIRIDAE INFECTION 有权CHICERIC POLY PEPTIDES及其对FLAVIVIRIDIDA感染的治疗用途公开(公告)号：US20100226924A1
公开(公告)日：2010-09-09
申请号：US11917907
申请日：2006-06-20
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： A61K39/395 , C07K14/005 , C12N15/40 , C12N15/63 , C12N15/00 , A61K39/12 , A61P31/12 , A61P37/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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公开(公告)号：US20060073164A1
公开(公告)日：2006-04-06
申请号：US11210960
申请日：2005-08-25
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
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7.发明授权Chimeric poly peptides and the therapeutic use thereof against a flaviviridae infection 有权嵌合多肽及其针对黄病毒科感染的治疗用途公开(公告)号：US08853379B2
公开(公告)日：2014-10-07
申请号：US13089705
申请日：2011-04-19
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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公开(公告)号：US20070128224A1
公开(公告)日：2007-06-07
申请号：US10581356
申请日：2004-12-02
申请人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoit Callendret , Jean-Michel Betton , Valerie Lorin , Sylvie Gerbaud , Ana Burguiere , Saliha Azebi , Pierre Charneau , Frederic Tangy , Chantal Combredet , Jean-Francois Delagneau , Monique Martin
发明人： Sylvie Van Der Werf , Nicolas Escriou , Bernadette Crescenzo-Chaigne , Jean-Claude Manuguerra , Frederick Kunst , Benoit Callendret , Jean-Michel Betton , Valerie Lorin , Sylvie Gerbaud , Ana Burguiere , Saliha Azebi , Pierre Charneau , Frederic Tangy , Chantal Combredet , Jean-Francois Delagneau , Monique Martin
IPC分类号： A61K39/215 , C12Q1/70 , C07H21/04 , C07K14/165 , C07K16/10 , C12N5/06
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/20022 , G01N33/569
摘要： The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
摘要翻译： 本发明涉及由河内（越南）收集的样品，参考号031589，源自其基因组的核酸分子产生的重症急性呼吸综合征（SARS）相关冠状病毒的新型菌株，由所述 核酸分子，更具体地，蛋白N及其应用，例如作为诊断试剂和/或疫苗。
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9.发明授权Infectious cDNA of an approved vaccine strain of measles virus, use for immunogenic compositions 有权经证实的麻疹病毒疫苗株的感染性cDNA，用于免疫原性组合物公开(公告)号：US09005961B2
公开(公告)日：2015-04-14
申请号：US11013786
申请日：2004-12-17
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2795/10243
摘要： The invention relates to a cDNA molecule which encodes the nucleotide sequence of the full length antigenomic (+)RNA strand of a measles virus (MV) originating from an approved vaccine strain, for example, the Schwarz strain. It also concerns the preparation of infectious recombinant viruses and immunogenic compositions using the cDNA.
摘要翻译： 本发明涉及一种cDNA分子，其编码源自经批准的疫苗株，例如施瓦茨菌株的麻疹病毒（MV）的全长基因组（+）RNA链的核苷酸序列。 它还涉及使用cDNA制备感染性重组病毒和免疫原性组合物。
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10.发明授权Infectious cDNA of an approved vaccine strain of measles virus, use for immunogenic compositions 有权经证实的麻疹病毒疫苗株的感染性cDNA，用于免疫原性组合物公开(公告)号：US09005925B2
公开(公告)日：2015-04-14
申请号：US12219570
申请日：2008-07-24
IPC分类号： C07H21/04 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2795/10243
摘要： The invention relates to a cDNA molecule which encodes the nucleotide sequence of the full length antigenomic (+)RNA strand of a measles virus (MV) originating from an approved vaccine strain. It also contains the preparation of immunogenic compositions using said cDNA.
摘要翻译： 本发明涉及一种cDNA分子，其编码源自经批准的疫苗株的麻疹病毒（MV）的全长基因组（+）RNA链的核苷酸序列。 它还包含使用所述cDNA的免疫原性组合物的制备。
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