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公开(公告)号：US20060073164A1
公开(公告)日：2006-04-06
申请号：US11210960
申请日：2005-08-25
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
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2.发明授权Chimeric poly peptides and the therapeutic use thereof against a flaviviridae infection 有权嵌合多肽及其针对黄病毒科感染的治疗用途公开(公告)号：US08853379B2
公开(公告)日：2014-10-07
申请号：US13089705
申请日：2011-04-19
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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3.发明授权Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae infection 有权嵌合多肽及其针对黄病毒科感染的治疗用途公开(公告)号：US08337857B2
公开(公告)日：2012-12-25
申请号：US11917907
申请日：2006-06-20
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： A61K39/00 , A61K39/295 , A61K39/193
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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4.发明申请CHIMERIC POLY PEPTIDES AND THE THERAPEUTIC USE THEREOF AGAINST A FLAVIVIRIDAE INFECTION 有权CHICERIC POLY PEPTIDES及其对FLAVIVIRIDIDA感染的治疗用途公开(公告)号：US20100226924A1
公开(公告)日：2010-09-09
申请号：US11917907
申请日：2006-06-20
申请人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic Tangy , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： A61K39/395 , C07K14/005 , C12N15/40 , C12N15/63 , C12N15/00 , A61K39/12 , A61P31/12 , A61P37/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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5.发明申请CHIMERIC POLY PEPTIDES AND THE THERAPEUTIC USE THEREOF AGAINST A FLAVIVIRIDAE INFECTION 有权CHICERIC POLY PEPTIDES及其对FLAVIVIRIDIDA感染的治疗用途公开(公告)号：US20120201825A1
公开(公告)日：2012-08-09
申请号：US13089705
申请日：2011-04-19
申请人： Frederic TANGY , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic TANGY , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： A61K39/395 , C12P21/06 , C12N15/63 , A61K38/00 , A61P31/12 , C07K14/18 , C07K16/10 , C07H21/04 , A61P37/04 , A61K39/12 , A61K31/7088
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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6.发明授权Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications 有权登革热和西尼罗病毒蛋白质和编码前述的基因，以及它们在疫苗，治疗和诊断应用中的应用公开(公告)号：US07556812B2
公开(公告)日：2009-07-07
申请号：US11210960
申请日：2005-08-25
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译： 本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。 更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原， 异二聚体糖蛋白（pre me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。
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7.发明授权Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications 有权登革热和西尼罗病毒蛋白质和编码前述的基因，以及它们在疫苗，治疗和诊断应用中的应用公开(公告)号：US08859240B2
公开(公告)日：2014-10-14
申请号：US12476304
申请日：2009-06-02
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre-m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译： 本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。 更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原， 异二聚体糖蛋白（pre-me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。
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8.发明申请Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine 审中-公开用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用公开(公告)号：US20090214589A1
公开(公告)日：2009-08-27
申请号：US11596675
申请日：2005-05-16
IPC分类号： A61K39/12 , C12N15/867 , C12N5/00 , C12P21/06 , C12Q1/70
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
摘要翻译： 使用重组慢病毒载体，其包含编码至少一种黄病毒科病毒蛋白的多核苷酸片段或所述蛋白质的至少8个氨基酸的免疫原性肽，用于制备用于预防和/或治疗的药物组合物 的敏感物种中的黄病毒科感染。
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9.发明授权Attenuated flavivirus strains containing a mutated M-ectodomain and their applications 失效含有突变的M-胞外域的减毒黄病毒及其应用公开(公告)号：US07189403B2
公开(公告)日：2007-03-13
申请号：US10608029
申请日：2003-06-30
申请人： Philippe Despres , Adeline Catteau
发明人： Philippe Despres , Adeline Catteau
IPC分类号： A61K39/12 , A61K39/00 , A61K39/385 , C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24122 , C12N2770/24162 , G01N33/56983 , Y02A50/53 , Y02A50/60
摘要： The present invention relates to nine residue peptides (ApoptoM) from flavivirus M ectodomain able to modulate specifically the apoptotic activity of diverse flavivirus, to pharmaceutical composition comprising the same and their use for the treatment and/or the prevention of flavivirus-linked infections and cancers.
摘要翻译： 本发明涉及能够特异性调节多种黄病毒的凋亡活性的黄病毒M胞外域的九种残基肽（ApoptoM），包含其的药物组合物及其用于治疗和/或预防黄病毒相关感染和癌症的用途 。
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10.发明申请Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form 有权使用六聚体形式的黄病毒NS1蛋白具有高亲和力的抗体来测定黄病毒感染的检测公开(公告)号：US20050186562A1
公开(公告)日：2005-08-25
申请号：US11017048
申请日：2004-12-21
申请人： Marie Flamand , Francoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
发明人： Marie Flamand , Francoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
IPC分类号： A61K39/00 , A61K39/12 , A61K39/395 , A61K48/00 , A61P31/14 , C07K14/18 , C07K16/10 , C12N15/09 , C12P21/02 , G01N33/543 , G01N33/569 , G01N33/577 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immumological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
摘要翻译： 本发明涉及用于早期检测黄病毒诱导的感染的方法，包括在感染的临床阶段通过使用至少两种相同或不同抗体的免疫学方法检测生物样品中的黄病毒非结构性糖蛋白NS1 第一抗体由预先选择的多克隆抗体或单克隆抗体，因为它们对所述NS1蛋白六聚体形状的高亲和力。
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