公开(公告)号：US20170182432A1

公开(公告)日：2017-06-29

申请号：US15458667

申请日：2017-03-14

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/20 ,  G01N30/60 ,  G01N30/56 ,  B01D15/22 ,  B01D15/14

CPC classification number: B01D15/206 ,  B01D15/14 ,  B01D15/22 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/606 ,  G01N2030/565

Abstract: The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of: pre-sterilize an empty chromatography column; pre-sterilize a chromatography medium; introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thereby providing an aseptic chromatography column comprising chromatography medium.

公开(公告)号：US09597611B2

公开(公告)日：2017-03-21

申请号：US13672832

申请日：2012-11-09

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/20 ,  B01D15/22 ,  G01N30/56 ,  G01N30/60 ,  B01D15/14

CPC classification number: B01D15/206 ,  B01D15/14 ,  B01D15/22 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/606 ,  G01N2030/565

Abstract: A method for providing an aseptic chromatography column includes the steps of pre-sterilizing an empty chromatography column, pre-sterilizing a chromatography medium, introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thus providing an aseptic chromatography column comprising chromatography medium.

公开(公告)号：US10048235B2

公开(公告)日：2018-08-14

申请号：US15379447

申请日：2016-12-14

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: G01N30/60 ,  G01N30/38 ,  B01D15/22 ,  B01D15/18 ,  B01D15/26

Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

公开(公告)号：US09597610B2

公开(公告)日：2017-03-21

申请号：US13672819

申请日：2012-11-09

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/20 ,  B01D15/22 ,  G01N30/56 ,  B01D15/14 ,  G01N30/60

CPC classification number: B01D15/206 ,  B01J2220/56 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/606 ,  G01N2030/565 ,  Y10T137/0402

Abstract: The invention relates to a system for packing chromatography columns with a chromatography medium and packing method for use in such columns. In particular, the invention relates to a method and system for packing chromatography columns where the column and chromatography media are pre-sterilized.

公开(公告)号：US20190324001A1

公开(公告)日：2019-10-24

申请号：US16459525

申请日：2019-07-01

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer

IPC: G01N30/60 ,  B01D15/18 ,  B01D15/22

Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

公开(公告)号：US20190224588A1

公开(公告)日：2019-07-25

申请号：US16306619

申请日：2017-06-19

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer ,  Spyridon Gerontas ,  Jamil Shanagar

IPC: B01D15/20 ,  B01D15/18 ,  G01N30/46 ,  G01N30/56 ,  G01N30/60 ,  A61L2/08

Abstract: The invention discloses a method for packing a plurality of uniform chromatography columns, comprising the steps of: a) providing a plurality of chromatography columns; b) providing a plurality of chromatography resin aliquots; c) packing the chromatography resin aliquots in the chromatography columns to provide a plurality of packed chromatography columns; and d) subjecting the packed chromatography columns to repeated mechanical impacts to provide a plurality of uniform chromatography columns.

公开(公告)号：US20190154639A1

公开(公告)日：2019-05-23

申请号：US16067628

申请日：2017-01-06

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer ,  Dan Hermansson

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/56 ,  B01D15/20

Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube (3,19,21) having a closed first end (5) comprising an inlet/outlet (7), a media inlet (15) adjacent a second end of the column tube and an adaptor (9) positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.

公开(公告)号：US20180356375A1

公开(公告)日：2018-12-13

申请号：US16103149

申请日：2018-08-14

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: G01N30/60 ,  B01D15/22 ,  B01D15/18

CPC classification number: G01N30/6004 ,  B01D15/18 ,  B01D15/22 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6052 ,  G01N30/606

Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

公开(公告)号：US20180229152A1

公开(公告)日：2018-08-16

申请号：US15954545

申请日：2018-04-16

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer ,  Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

IPC: B01D15/22 ,  B01D15/18 ,  G01N30/46 ,  G01N30/60 ,  F16L55/00

CPC classification number: B01D15/22 ,  B01D15/1864 ,  B01D15/1885 ,  F16L55/00 ,  G01N30/461 ,  G01N30/466 ,  G01N30/6004 ,  Y10T29/49826

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

公开(公告)号：US09950277B2

公开(公告)日：2018-04-24

申请号：US14290357

申请日：2014-05-29

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/14 ,  G01N30/60 ,  G01N30/46 ,  B01D15/18 ,  B01D15/22 ,  G01N30/88

CPC classification number: B01D15/14 ,  B01D15/1864 ,  B01D15/1885 ,  B01D15/22 ,  G01N30/466 ,  G01N30/6039 ,  G01N30/6043 ,  G01N30/6091 ,  G01N2030/8881 ,  Y10T29/49826

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.