公开(公告)号：US10124328B2

公开(公告)日：2018-11-13

申请号：US15407240

申请日：2017-01-16

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Jesper Hansson ,  Gustav Rodrigo ,  Tobias E Soderman

IPC: B01J39/26 ,  B01D15/18 ,  B01D15/36 ,  B01J20/286 ,  B01J20/32 ,  B01D15/38 ,  B01J20/26 ,  B01J20/28 ,  B01J20/289 ,  B01J20/30 ,  C07H1/08 ,  C07K1/22 ,  B01D15/34 ,  B01J20/24 ,  G01N30/88

Abstract: The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH2═CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.

公开(公告)号：US09573973B2

公开(公告)日：2017-02-21

申请号：US14396207

申请日：2013-04-22

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Jesper Hansson ,  Gustav Rodrigo ,  Tobias E Soderman

IPC: B01D15/36 ,  C07K1/22 ,  B01D15/18 ,  B01J20/286 ,  B01J20/32 ,  B01D15/38 ,  B01J20/26 ,  B01J20/28 ,  B01J20/289 ,  B01J20/30 ,  C07H1/08 ,  G01N30/88

CPC classification number: B01J39/26 ,  B01D15/1864 ,  B01D15/34 ,  B01D15/361 ,  B01D15/362 ,  B01D15/3809 ,  B01J20/24 ,  B01J20/261 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28014 ,  B01J20/28033 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3212 ,  B01J20/3278 ,  B01J20/3282 ,  B01J2220/80 ,  C07H1/08 ,  C07K1/22 ,  G01N2030/8827 ,  Y02P20/582

Abstract: The invention discloses a method of separating a biomolecule from at least one other component in a liquid, comprising a step of contacting said liquid with a separation matrix comprising a solid support and polymer chains bound to said solid support. The polymer chains comprise units derived from a first monomer of structure CH2═CH-L-X, where L is a covalent bond or an alkyl ether or hydroxysubstituted alkyl ether chain comprising 2-6 carbon atoms, and X is a sulfonate or phosphonate group.

Abstract translation: 本发明公开了一种从液体中的至少一种其它组分分离生物分子的方法，包括使所述液体与包含固体支持物和与所述固体支持物结合的聚合物链的分离基质接触的步骤。 聚合物链包含衍生自结构为CH 2 = CH-L-X的第一单体的单元，其中L为共价键或包含2-6个碳原子的烷基醚或羟基取代的烷基醚链，X为磺酸盐或膦酸酯基团。