公开(公告)号：US20250074881A1

公开(公告)日：2025-03-06

申请号：US18823182

申请日：2024-09-03

Applicant: Genentech, Inc.

Inventor： Jason Robert ZBIEG ,  Russell Tyler SMITH ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Curtis COLWELL ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20230203062A1

公开(公告)日：2023-06-29

申请号：US18057742

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert ZBIEG ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Liang ZHAO ,  Melissa LEBLANC ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA ,  Russell Tyler SMITH

IPC: C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

CPC classification number: C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20230159555A1

公开(公告)日：2023-05-25

申请号：US17814115

申请日：2022-07-21

Applicant: Genentech, Inc.

Inventor： Paul GIBBONS ,  Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Bing-Yan ZHU ,  Huifen CHEN

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B),




solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

公开(公告)号：US20160244456A1

公开(公告)日：2016-08-25

申请号：US15144422

申请日：2016-05-02

Applicant: Genentech, Inc.

Inventor： Jeffrey BLANEY ,  Paul A. GIBBONS ,  Emily HANAN ,  Joseph P. LYSSIKATOS ,  Steven R. MAGNUSON ,  Richard PASTOR ,  Thomas E. RAWSON ,  Aihe ZHOU ,  Bing-Yan ZHU

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The invention provides JAK kinase inhibitors of Formula Ia, enantiomers, diasteriomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and Z are defined herein, a pharmaceutical composition that includes a compound of Formula Ia and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a JAK kinase activity in a patient.

Abstract translation: 本发明提供了式Ia的JAK激酶抑制剂，其对映体，非对映异构体或其药学上可接受的盐，其中R1，R2，R7和Z在本文中定义，药物组合物包括式Ia化合物和药学上可接受的载体，佐剂或载体 以及对患者中JAK激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。