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公开(公告)号：US10407424B2
公开(公告)日：2019-09-10
申请号：US15942321
申请日：2018-03-30
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Blake Daniels , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca
IPC: C07D471/04 , A61K31/55 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K45/06
Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
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公开(公告)号：US20210332064A1
公开(公告)日：2021-10-28
申请号：US17220307
申请日：2021-04-01
Applicant: Genentech, Inc.
Inventor： Jun Liang , Rohan V. Mendonca , Michael Siu , John Tellis , Weiru Wang , BinQing Wei , Bryan Chan , Edna F. Choo , Joy Drobnick , Lewis J. Gazzard , Timothy Heffron
IPC: C07D498/04 , C07D401/04 , C07D401/14 , C07D519/00
Abstract: 3-Carbonylaminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylaminoisoquinoline compounds.
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公开(公告)号：US11034692B1
公开(公告)日：2021-06-15
申请号：US16542129
申请日：2019-08-15
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC: C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
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公开(公告)号：US09453079B2
公开(公告)日：2016-09-27
申请号：US14292461
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07K16/18 , A61K39/395 , C07K16/40 , A61K47/48 , G01N33/573 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US20240368170A1
公开(公告)日：2024-11-07
申请号：US18769184
申请日：2024-07-10
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Michael Siu , Weiru Wang , BinQing Wei , Aihe Zhou , Bryan K. Chan , Lewis J. Gazzard , Timothy Heffron , Michael Lainchbury , Andrew Madin , Eileen Mary Seward , Matthew W. Cartwright , Emanuela Gancia , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu
IPC: C07D487/04 , C07D237/28 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04
Abstract: Cinnoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the cinnoline compounds.
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Patent Agency Ranking
公开(公告)号：US09879094B2
公开(公告)日：2018-01-30
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07H21/04 , C07K16/18 , C12P21/08 , C07K16/40 , A61K39/395 , G01N33/573 , C12P21/00 , A61K47/68 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
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![Substituted pyrrolo[2,3-b]pyrazines as serine/threonine kinase inhibitors](/abs-image/US/2016/07/05/US09382257B2/abs.jpg.150x150.jpg)
7.发明授权Substituted pyrrolo[2,3-b]pyrazines as serine/threonine kinase inhibitors 有权取代的吡咯并[2,3-b]吡嗪作为丝氨酸/苏氨酸激酶抑制剂公开(公告)号：US09382257B2
公开(公告)日：2016-07-05
申请号：US14688724
申请日：2015-04-16
Applicant: Genentech, Inc.
Inventor： Daniel Burdick , Huifen Chen , Shumei Wang , Weiru Wang
IPC: A61K31/4985 , C07D231/10 , C07D241/38 , C07D487/04 , A61K45/06
CPC classification number: C07D487/04 , A61K31/4985 , A61K45/06
Abstract: Compounds having the formula I wherein R1 and R2 are as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式I的化合物，其中R 1和R 2如本文所定义，是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：US11612606B2
公开(公告)日：2023-03-28
申请号：US16592502
申请日：2019-10-03
Applicant: Genentech, Inc.
Inventor： Jun Liang , Rohan V. Mendonca , Michael Siu , John Tellis , Weiru Wang , BinQing Wei , Bryan Chan , Edna F. Choo , Joy Drobnick , Lewis J. Gazzard , Timothy Heffron
IPC: A61K31/5383 , A61K31/4725 , C07D498/04 , C07D498/08 , A61K31/4375 , C07D491/052 , A61K31/436 , A61K31/551 , C07D471/04 , A61K31/439
Abstract: 3-Carbonylamino-8-aminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline compounds.
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公开(公告)号：US20210163417A1
公开(公告)日：2021-06-03
申请号：US16921297
申请日：2020-07-06
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Michael Lainchbury , Emanuela Gancia , Eileen Seward , Andrew Madin , David Favor , Kin Chiu Fong , Yonghan Hu , Andrew Good
IPC: C07D217/22 , A61K31/549 , A61P35/00 , A61K45/06 , C07D401/04 , A61K31/4725 , A61K31/506 , A61K31/501 , C07D471/04 , C07D413/04 , C07D413/14 , A61K31/5377 , C07D417/04 , A61K31/4985 , C07D401/14 , C07D487/04 , A61K31/551 , C07D498/04 , A61K31/5383 , C07D405/14 , C07D519/00 , C07D498/14 , C07D513/04 , A61K31/554 , A61K31/55 , A61K31/472 , C07D409/14 , C07D491/04 , C07D487/14
Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
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公开(公告)号：US20180282328A1
公开(公告)日：2018-10-04
申请号：US15942321
申请日：2018-03-30
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC: C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
CPC classification number: C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K45/06 , A61P35/00 , C07D519/00
Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
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