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1.发明申请公开(公告)号：US20230065295A1
公开(公告)日：2023-03-02
申请号：US17369871
申请日：2021-07-07
Applicant: Genomatica, Inc.
Inventor： Priti Pharkya , Anthony P. Burgard , Stephen J. Van Dien , Robin E. Osterhout , Mark J. Burk , John D. Trawick , Michael P. Kuchinskas , Brian Steer
IPC: C12N1/20 , C12P7/18 , C12N9/18 , C12N15/52 , C12P7/42 , C12N1/14 , C12N1/16 , C12N15/63 , C07C31/20 , C07C59/01 , C08G18/28 , C08G18/32 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02
Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.
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2.发明申请MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 审中-公开用于生产4-羟基丁酸酯，1,4-丁二醇和相关化合物的微生物和方法公开(公告)号：US20150148513A1
公开(公告)日：2015-05-28
申请号：US14405390
申请日：2013-06-03
Applicant: Genomatica, Inc.
Inventor： Priti Pharkya , Anthony P. Burgard , Stephen J. Van Dien , Robin E. Osterhout , Mark J. Burk , John D. Trawick , Michael P. Kuchinskas , Brian Steer
IPC: C12N1/20 , C12P7/18 , C07C59/01 , C07C31/20 , C08G69/02 , C08G18/28 , C08G63/06 , C08G63/16 , C08G63/181 , C12P7/42 , C08G18/32
CPC classification number: C12N1/20 , C07C31/207 , C07C59/01 , C08G18/284 , C08G18/3206 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02 , C12N9/18 , C12N15/52 , C12N15/63 , C12P7/18 , C12P7/42 , C12Y301/01 , Y02P20/52
Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.
Abstract translation: 本发明提供具有4-羟基丁酸酯，1,4-丁二醇或其它产物途径的非天然存在的微生物生物，并能够生产4-羟基丁酸酯，1,4-丁二醇或其它产品，其中微生物有机体包含一个 或更多遗传修饰。 本发明另外提供了使用微生物生物制备4-羟基丁酸酯，1,4-丁二醇或其它产品或相关产品的方法。
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3.发明授权公开(公告)号：US11932845B2
公开(公告)日：2024-03-19
申请号：US14405390
申请日：2013-06-03
Applicant: Genomatica, Inc.
Inventor： Priti Pharkya , Anthony P. Burgard , Stephen J. Van Dien , Robin E. Osterhout , Mark J. Burk , John D. Trawick , Michael P. Kuchinskas , Brian Steer
IPC: C12N9/18 , C12P7/42 , C12P7/52 , C12N1/20 , C12P7/18 , C12N15/52 , C12N1/14 , C12N1/16 , C12N15/63 , C07C31/20 , C07C59/01 , C08G18/28 , C08G18/32 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02
CPC classification number: C12N1/20 , C07C31/207 , C07C59/01 , C08G18/284 , C08G18/3206 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02 , C12N1/14 , C12N1/16 , C12N9/18 , C12N15/52 , C12N15/63 , C12P7/18 , C12P7/42 , C12Y301/01 , Y02P20/52
Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.
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公开(公告)号：US10662451B2
公开(公告)日：2020-05-26
申请号：US15971878
申请日：2018-05-04
Applicant: Genomatica, Inc.
Inventor： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
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公开(公告)号：US10273508B2
公开(公告)日：2019-04-30
申请号：US15148759
申请日：2016-05-06
Applicant: Genomatica, Inc.
Inventor： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20180334690A1
公开(公告)日：2018-11-22
申请号：US15889788
申请日：2018-02-06
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Christophe H. Schilling , Anthong P. Burgard , John D. Trawick
CPC classification number: C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
Abstract: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
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7.发明授权公开(公告)号：US09885064B2
公开(公告)日：2018-02-06
申请号：US14185709
申请日：2014-02-20
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC: C12N1/20 , C12N1/12 , C12P7/62 , C12P7/04 , C07H21/04 , C12P7/18 , C12N9/02 , C12N9/10 , C12N9/00 , C12P19/32 , C12N15/70
CPC classification number: C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
Abstract: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
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8.发明申请公开(公告)号：US20190276863A1
公开(公告)日：2019-09-12
申请号：US15971878
申请日：2018-05-04
Applicant: Genomatica, Inc.
Inventor： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
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公开(公告)号：US09988656B2
公开(公告)日：2018-06-05
申请号：US14954487
申请日：2015-11-30
Applicant: Genomatica, Inc.
Inventor： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
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10.发明授权公开(公告)号：US09677045B2
公开(公告)日：2017-06-13
申请号：US13908907
申请日：2013-06-03
Applicant: Genomatica, Inc.
Inventor： Priti Pharkya , Anthony P. Burgard , Stephen J. Van Dien , Robin E. Osterhout , Mark J. Burk , John D. Trawick , Michael P. Kuchinskas , Brian Steer
IPC: C12N1/20 , C12P7/42 , C12N15/63 , C12P7/18 , C12N9/18 , C12N15/52 , C07C31/20 , C07C59/01 , C08G18/28 , C08G18/32 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02
CPC classification number: C12N1/20 , C07C31/207 , C07C59/01 , C08G18/284 , C08G18/3206 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02 , C12N9/18 , C12N15/52 , C12N15/63 , C12P7/18 , C12P7/42 , C12Y301/01 , Y02P20/52
Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.
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