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公开(公告)号：US20080220438A1
公开(公告)日：2008-09-11
申请号：US12109615
申请日：2008-04-25
申请人： Gregg B. Morin , Serge Lichtsteiner , Alain Philippe Vasserot , Robert Adams , William H. Andrews
发明人： Gregg B. Morin , Serge Lichtsteiner , Alain Philippe Vasserot , Robert Adams , William H. Andrews
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). The disclosure also provides systems using TERT promoter sequences for identifying compounds that can be used to modulate telomerase expression
摘要翻译： 端粒酶逆转录酶是负责维持端粒长度和增加祖细胞复制能力的端粒酶复合物的一部分。 端粒酶活性在成熟分化细胞中被关闭，但在包括许多癌症在内的增生性疾病中又重新开始。 本公开提供了在表达端粒酶逆转录酶（TERT）的细胞中促进转录的调节元件。 本公开还提供了使用TERT启动子序列鉴定可用于调节端粒酶表达的化合物的系统
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公开(公告)号：US07378244B2
公开(公告)日：2008-05-27
申请号：US11411604
申请日：2006-04-25
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). The disclosure also provides systems using TERT promoter sequences for identifying compounds that can be used to modulate telomerase expression.
摘要翻译： 端粒酶逆转录酶是负责维持端粒长度和增加祖细胞复制能力的端粒酶复合物的一部分。 端粒酶活性在成熟分化细胞中被关闭，但在包括许多癌症在内的增生性疾病中又重新开始。 本公开提供了在表达端粒酶逆转录酶（TERT）的细胞中促进转录的调节元件。 本公开还提供了使用TERT启动子序列鉴定可用于调节端粒酶表达的化合物的系统。
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公开(公告)号：US20090269739A1
公开(公告)日：2009-10-29
申请号：US11894600
申请日：2007-08-20
申请人： Thomas R. Cech , Joachim Lingner , Toru M. Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru M. Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
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4.发明授权公开(公告)号：US07199234B2
公开(公告)日：2007-04-03
申请号：US10325810
申请日：2002-12-20
申请人： Gregg B. Morin , William H. Andrews
发明人： Gregg B. Morin , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K16/40 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Y207/07049 , G01N33/574 , G01N2333/9125
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
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公开(公告)号：US07195911B2
公开(公告)日：2007-03-27
申请号：US10044539
申请日：2002-01-11
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12N2501/70 , C12N2510/00 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Y207/07049
摘要： The present invention is directed to cells comprising a recombinant polynucleotide sequence that encodes a telomerase reverse transcriptase protein, variant, or fragment having telomerase catalytic activity when complexed with a telomerase RNA.
摘要翻译： 本发明涉及包含编码端粒酶逆转录酶蛋白，变体或与端粒酶RNA复合时具有端粒酶催化活性的片段的重组多核苷酸序列的细胞。
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6.发明授权Methods for detecting nucleic acids encoding human telomerase reverse transcriptase 失效检测编码人端粒酶逆转录酶的核酸的方法公开(公告)号：US07005262B2
公开(公告)日：2006-02-28
申请号：US10054611
申请日：2002-01-18
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Y207/07049
摘要： The present invention is directed to methods of identifying in a sample nucleic acids that encode human telomerase reverse transcriptase (hTRT) or its fragments. The present invention is also directed to oligonucleotide primers used in such methods. The invention is further directed to PCR products that hybridize under stringent conditions to a polynucleotide encoding hTRT, as well as hybridization complexes comprising one strand of a cellular hTRT nucleic acid and one strand of nucleic acid comprising a recombinant or synthetic fragment of hTRT.
摘要翻译： 本发明涉及鉴定编码人端粒酶逆转录酶（hTRT）或其片段的样品核酸的方法。 本发明还涉及用于这些方法的寡核苷酸引物。 本发明进一步涉及在严格条件下与编码hTRT的多核苷酸杂交的PCR产物，以及包含细胞hTRT核酸的一条链和包含hTRT的重组或合成片段的一条核酸链的杂交复合物。
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公开(公告)号：US08222392B2
公开(公告)日：2012-07-17
申请号：US11894600
申请日：2007-08-20
申请人： Thomas R. Cech , Joachim Lingner , Toru M. Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru M. Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
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8.发明授权Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity 失效人端粒酶逆转录酶突变体缺乏端粒酶催化活性公开(公告)号：US07517971B1
公开(公告)日：2009-04-14
申请号：US09721477
申请日：2000-11-22
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供了与人类端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
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9.发明授权Nucleic acids encoding human telomerase reverse transcriptase and related homologs 有权核酸编码人端粒酶逆转录酶及相关同系物公开(公告)号：US07262288B1
公开(公告)日：2007-08-28
申请号：US09721506
申请日：2000-11-22
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
CPC分类号： C12N9/1241 , C12N9/1276
摘要： The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
摘要翻译： 本发明提供与人端粒酶逆转录酶（hTRT），人端粒酶的催化蛋白质亚基相关的组合物和方法。 本发明的多核苷酸和多肽可用于人类疾病的诊断，预后和治疗，用于改变细胞和生物体的增殖能力，以及用于鉴定和筛选用于治疗诸如癌症的疾病的化合物和治疗。
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公开(公告)号：US06921664B2
公开(公告)日：2005-07-26
申请号：US10054295
申请日：2002-01-18
申请人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
发明人： Thomas R. Cech , Joachim Lingner , Toru Nakamura , Karen B. Chapman , Gregg B. Morin , Calvin B. Harley , William H. Andrews
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C12N9/12 , C12N15/113 , C12N15/12 , C12N5/00 , C12N5/06 , C12N9/60 , C12N15/14
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Q1/6895 , C12Y207/07049
摘要： The present invention is directed to expression vectors comprising a polynucleotide that encodes a human telomerase reverse transcriptase (hTRT) protein, variant, or fragment. The present invention is also directed to host cells that comprise expression vectors comprising a polynucleotide that encodes a hTRT protein variant, or fragment.
摘要翻译： 本发明涉及包含编码人端粒酶逆转录酶（hTRT）蛋白，变体或片段的多核苷酸的表达载体。 本发明还涉及包含表达载体的宿主细胞，其包含编码hTRT蛋白质变体或片段的多核苷酸。
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