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公开(公告)号：US20130131334A1
公开(公告)日：2013-05-23
申请号：US13263708
申请日：2010-04-07
申请人： Gyula Dékany , Károly Ágoston , Istvan Bajza , Julien Boutet , Marie Bøjstrup , Mette Fanefjord , Ignacio Pérez Figueroa , Markus Hederos , Ference Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
发明人： Gyula Dékany , Károly Ágoston , Istvan Bajza , Julien Boutet , Marie Bøjstrup , Mette Fanefjord , Ignacio Pérez Figueroa , Markus Hederos , Ference Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及式（1）三糖的改进合成，用于合成和制备中间体的新型中间体。
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公开(公告)号：US09012625B2
公开(公告)日：2015-04-21
申请号：US13263708
申请日：2010-04-07
申请人： Gyula Dékany , Károly Ágoston , Istvan Bajza , Julien Boutet , Marie Bøjstrup , Mette Fanefjord , Ignacio Pérez Figueroa , Markus Hederos , Ferenc Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
发明人： Gyula Dékany , Károly Ágoston , Istvan Bajza , Julien Boutet , Marie Bøjstrup , Mette Fanefjord , Ignacio Pérez Figueroa , Markus Hederos , Ferenc Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
IPC分类号： C07H3/00 , C08B37/00 , C12P19/04 , C07H1/06 , C07H1/08 , C07H3/06 , C07H15/04 , C07H15/203 , C07H1/00
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及式（1）的三糖的改进合成，用于合成和制备中间体的新中间体。
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公开(公告)号：US08927698B2
公开(公告)日：2015-01-06
申请号：US13263716
申请日：2010-04-07
申请人： Gyula Dékany , Istvan Bajza , Julien Boutet , Ignacio Pérez Figueroa , Markus Hederos , Ferenc Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
发明人： Gyula Dékany , Istvan Bajza , Julien Boutet , Ignacio Pérez Figueroa , Markus Hederos , Ferenc Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
IPC分类号： C07H3/06 , C07H15/203 , C07H15/26 , C07H1/00 , C07H15/04
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及下式的三糖的改进合成：用于合成和制备中间体的新型中间体。
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公开(公告)号：US20130035481A1
公开(公告)日：2013-02-07
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Pérez Figueroa , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Pérez Figueroa , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-0-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-0-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及制备三糖6'-唾液酸乳糖（式（I））或其盐的方法，以及在药物或营养物质中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
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5.发明申请METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE 有权含有N-乙酰基氨基甲酰胺的四氯化钛 - 新近硝酸酯（LNNT）的制备方法公开(公告)号：US20120309949A1
公开(公告)日：2012-12-06
申请号：US13579741
申请日：2011-02-21
申请人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Pérez Figueroa , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
发明人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Pérez Figueroa , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
IPC分类号： C08B37/00 , C07H15/203
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , C07H1/00 , C07H11/00 , C07H13/04 , C07H15/18 , A23V2250/28
摘要： The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，一种LNnt的新晶型（多晶型物）和 在药物或营养组合物中的应用。
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公开(公告)号：US20130072675A1
公开(公告)日：2013-03-21
申请号：US13698430
申请日：2011-05-19
申请人： Julien Boutet , Gyula Dekany , Ágnes Jánosi , Gergely Pipa , Ferenc Horváth , Krisztián Kovács , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkó , Lars Kröger , Christoph Röhrig
发明人： Julien Boutet , Gyula Dekany , Ágnes Jánosi , Gergely Pipa , Ferenc Horváth , Krisztián Kovács , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkó , Lars Kröger , Christoph Röhrig
IPC分类号： C07H1/06
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
摘要翻译： 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。
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公开(公告)号：US08901291B2
公开(公告)日：2014-12-02
申请号：US13698430
申请日：2011-05-19
申请人： Julien Boutet , Gyula Dekany , Ágnes Jànosi , Gergely Pipa , Ferenc Horvàth , Krisztián Kovàcs , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkò , Lars Kröger , Christoph Röhrig
发明人： Julien Boutet , Gyula Dekany , Ágnes Jànosi , Gergely Pipa , Ferenc Horvàth , Krisztián Kovàcs , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkò , Lars Kröger , Christoph Röhrig
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
摘要翻译： 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。
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公开(公告)号：US09237764B2
公开(公告)日：2016-01-19
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
IPC分类号： C07H1/00 , C07H3/04 , C07H5/04 , C07H5/10 , A23L1/308 , C07H3/06 , C07H15/18 , A61K31/702 , C07H13/04 , A23L1/30
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-O-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及三糖6'-O-唾液乳糖（式（I））或其盐的制备方法以及在制备或营养中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
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公开(公告)号：US20130172548A1
公开(公告)日：2013-07-04
申请号：US13809829
申请日：2011-07-15
申请人： Gyula Dekany , Istvan Bajza , Károly Ágoston , Ignacio Figueroa Pérez , Markus Hedros , Andreas Schroven , Ioannis Vrasidas , Julien Boutet , Lars Kröger , Christoph Röhrig , Imre Kovacs , Péter Trinka , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , László Kalmár , Elise Champion
发明人： Gyula Dekany , Istvan Bajza , Károly Ágoston , Ignacio Figueroa Pérez , Markus Hedros , Andreas Schroven , Ioannis Vrasidas , Julien Boutet , Lars Kröger , Christoph Röhrig , Imre Kovacs , Péter Trinka , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , László Kalmár , Elise Champion
IPC分类号： C07H1/06
摘要： A method for purifying, separating and/or isolating an oligosaccharide or a salt thereof is presented. An embodiment of the invention is based upon the formation of anomeric O-benzyl/substituted O-benzyl derivatives in a selective anomeric alkylation reaction.
摘要翻译： 提出了一种纯化，分离和/或分离寡糖或其盐的方法。 本发明的一个实施方案基于在选择性端基异构烷基化反应中形成端基异构O-苄基/取代的O-苄基衍生物。
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公开(公告)号：US20130165406A1
公开(公告)日：2013-06-27
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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