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公开(公告)号：US08034338B2
公开(公告)日：2011-10-11
申请号：US10552324
申请日：2004-04-16
CPC分类号： C07K16/42 , A61K2039/505 , C07K2317/52 , C07K2319/00
摘要： The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
摘要翻译： 本发明涉及设计用于免疫含有至少一部分鼠IgG2a亚型氨基酸序列和哺乳动物糖基化的灵长类动物的免疫原性重组抗体。
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公开(公告)号：US20110020331A1
公开(公告)日：2011-01-27
申请号：US12786378
申请日：2010-05-24
申请人： Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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公开(公告)号：US20070258978A1
公开(公告)日：2007-11-08
申请号：US10552324
申请日：2004-04-16
IPC分类号： C07K16/00 , A61K39/395 , C07K16/42 , C12N1/00 , C12P21/00 , G01N33/53 , C12P21/08 , C12N15/63 , C07K16/46 , A61P39/00
CPC分类号： C07K16/42 , A61K2039/505 , C07K2317/52 , C07K2319/00
摘要： The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
摘要翻译： 本发明涉及设计用于免疫含有至少一部分鼠IgG2a亚型氨基酸序列和哺乳动物糖基化的灵长类动物的免疫原性重组抗体。
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公开(公告)号：US20070243201A1
公开(公告)日：2007-10-18
申请号：US10559131
申请日：2004-06-02
申请人： Hans Loibner , Gottfried Himmler , Alois Jungbauer , Erich Wasserbauer , Manfred Schuster , Rainer Hahn , Astrid Durauer
发明人： Hans Loibner , Gottfried Himmler , Alois Jungbauer , Erich Wasserbauer , Manfred Schuster , Rainer Hahn , Astrid Durauer
CPC分类号： C07K16/3076 , A61K2039/505 , C07K14/4748
摘要： The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.
摘要翻译： 本发明涉及用于选择免疫治疗表位的方法，通过所述方法获得的肽，所述肽作为疫苗和诊断的用途以及通过所述方法可获得的免疫血清。
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5.发明申请公开(公告)号：US20060018901A1
公开(公告)日：2006-01-26
申请号：US11185299
申请日：2005-07-20
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , A61K2039/545 , A61K2039/55505
摘要： The use of an antibody directed against the cellular membrane antigen EpCAM for the production of a pharmaceutical preparation for the prophyactic and/or therapeutic active immunization against cancer is provided whereby the antibody is in an amount of 1 ng to 9 μg.
摘要翻译： 提供了针对细胞膜抗原EpCAM的抗体用于制备用于针对癌症的前列腺和/或治疗性主动免疫的药物制剂，其中所述抗体的量为1ng至9ug。
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公开(公告)号：US20050181475A1
公开(公告)日：2005-08-18
申请号：US10514529
申请日：2003-05-15
申请人： Hans Loibner , Gunter Waxenecker , Gottfried Himmler , Helmut Eckert , Manfred Schuster , Ralf Kircheis
发明人： Hans Loibner , Gunter Waxenecker , Gottfried Himmler , Helmut Eckert , Manfred Schuster , Ralf Kircheis
IPC分类号： A61K39/00 , A61K47/48 , C07K16/30 , C07K16/42 , C12P21/06 , A61K39/395 , C07H21/04 , C12N5/06
CPC分类号： A61K39/0011 , A61K47/68 , A61K2039/6056 , C07K16/30 , C07K16/4266
摘要： The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
摘要翻译： 本发明涉及包含肿瘤相关抗原的至少两个不同表位的免疫原性抗体。
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公开(公告)号：US20080095783A1
公开(公告)日：2008-04-24
申请号：US11571983
申请日：2004-07-14
申请人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395 , A61P43/00 , C07K16/18
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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公开(公告)号：US08323650B2
公开(公告)日：2012-12-04
申请号：US12786378
申请日：2010-05-24
申请人： Manfred Schuster , Gottfried Himmler , Guenter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Guenter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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公开(公告)号：US07759464B2
公开(公告)日：2010-07-20
申请号：US11571983
申请日：2004-07-14
申请人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及识别Lewis Y抗原的来自亲本单克隆抗体的单克隆抗体或抗体片段，其特征在于抗体的Fc区或抗体的片段携带双链抗体， 所述杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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公开(公告)号：US08586319B2
公开(公告)日：2013-11-19
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译： 本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。 二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。
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