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公开(公告)号：US20130217728A1
公开(公告)日：2013-08-22
申请号：US13700752
申请日：2011-05-26
IPC分类号： C07D405/14 , C07D401/14
CPC分类号： C07D405/14 , C07D401/06 , C07D401/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (Ia) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及式（Ia）的CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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公开(公告)号：US09108958B2
公开(公告)日：2015-08-18
申请号：US13548321
申请日：2012-07-13
IPC分类号： A61K31/535 , C07D239/42 , C07D413/14 , C07D401/06 , C07D405/14 , C07D487/04 , C07D498/04 , C07D401/14
CPC分类号： C07D413/14 , C07D401/06 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel and selective antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD as well as pain.
摘要翻译： 本发明涉及CCR2（CC趋化因子受体2）的新型和选择性拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD以及疼痛的药物的用途。
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3.发明授权Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD 有权循环嘧啶-4-甲酰胺作为治疗炎症，哮喘和COPD的CCR2受体拮抗剂公开(公告)号：US08835440B2
公开(公告)日：2014-09-16
申请号：US13949696
申请日：2013-07-24
申请人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Thomas Trieselmann , Patrick Tielmann , Stefan Scheuerer , Silke Hobbie , Frank Buettner
发明人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Thomas Trieselmann , Patrick Tielmann , Stefan Scheuerer , Silke Hobbie , Frank Buettner
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D498/10 , C07D403/06 , A61K31/55 , C07D491/052 , C07D401/06 , A61K31/553 , C07D405/14 , C07D471/10 , C07D407/14 , C07D417/14 , A61K31/5377 , A61K31/551 , C07D471/04 , C07D403/14 , C07D451/02 , C07D401/14 , A61K31/506 , C07D413/14
CPC分类号： C07D498/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/052 , Y02A50/385 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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公开(公告)号：US08765949B2
公开(公告)日：2014-07-01
申请号：US12969745
申请日：2010-12-16
申请人： Heiner Ebel , Sara Frattini , Kai Gerlach , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Marco Santagostino , Stefan Scheuerer , Christofer Tautermann , Thomas Trieselmann
发明人： Heiner Ebel , Sara Frattini , Kai Gerlach , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Marco Santagostino , Stefan Scheuerer , Christofer Tautermann , Thomas Trieselmann
IPC分类号： C07D239/02 , C07D211/68 , C07D211/80 , C07D211/60 , A01N43/54 , A01N43/40 , A61K31/445 , A01N43/16 , A61K31/35 , C07D405/14 , C07D491/107
CPC分类号： C07D491/107 , C07D405/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
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公开(公告)号：US20130143905A1
公开(公告)日：2013-06-06
申请号：US13515852
申请日：2010-12-13
申请人： Heiner Ebel , Sara Frattini , Kai Gerlach , Riccardo Giovannini , Christoph Hoenke , Marco Santagostino , Stefan Scheuerer , Thomas Trieselmann
发明人： Heiner Ebel , Sara Frattini , Kai Gerlach , Riccardo Giovannini , Christoph Hoenke , Marco Santagostino , Stefan Scheuerer , Thomas Trieselmann
IPC分类号： C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及式（I）的CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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6.发明申请NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS 有权新CCR2受体拮抗剂，其生产方法及其作为药物的用途公开(公告)号：US20130090338A1
公开(公告)日：2013-04-11
申请号：US13696860
申请日：2011-05-10
申请人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Stefan Scheuerer
发明人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Stefan Scheuerer
IPC分类号： C07D413/14 , C07D401/14 , C07D405/14
CPC分类号： C07D413/14 , C07D401/06 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases.
摘要翻译： 本发明涉及用于CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD以及疼痛疾病的药物的用途。
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7.发明授权CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments 有权CCR2受体拮抗剂，其制备方法及其作为药物的用途公开(公告)号：US08946218B2
公开(公告)日：2015-02-03
申请号：US13696860
申请日：2011-05-10
申请人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Stefan Scheuerer
发明人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Stefan Scheuerer
IPC分类号： C07D401/14 , A61K31/506 , C07D413/14 , C07D401/06 , C07D405/14
CPC分类号： C07D413/14 , C07D401/06 , C07D401/14 , C07D405/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases.
摘要翻译： 本发明涉及用于CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD以及疼痛疾病的药物的用途。
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公开(公告)号：US20140323492A1
公开(公告)日：2014-10-30
申请号：US13699325
申请日：2011-05-23
IPC分类号： C07D405/14 , C07D401/14
CPC分类号： C07D405/14 , C07D401/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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公开(公告)号：US09018212B2
公开(公告)日：2015-04-28
申请号：US13699325
申请日：2011-05-23
IPC分类号： C07D405/14 , C07D401/14 , A61K31/501 , A61P13/12 , A61P25/00 , A61P11/00
CPC分类号： C07D405/14 , C07D401/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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10.发明授权CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments 有权CCR2受体拮抗剂，其制备方法及其作为药物的用途公开(公告)号：US08877745B2
公开(公告)日：2014-11-04
申请号：US13696859
申请日：2011-05-10
申请人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Stefan Scheuerer
发明人： Heiner Ebel , Sara Frattini , Riccardo Giovannini , Christoph Hoenke , Rocco Mazzaferro , Stefan Scheuerer
IPC分类号： C07D471/04 , A61K31/506 , C07D495/04 , C07D491/10 , C07D413/14 , C07D401/14 , C07D487/04 , C07D405/14 , C07D491/107
CPC分类号： C07D405/14 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D495/04
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) wherein HET is a group selected from among formulas (IIa) (IIb) (IIc) (IId) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases.
摘要翻译： 本发明涉及式（I）的CCR2（CC趋化因子受体2）的新型拮抗剂，其中HET是选自式（IIa）（IIb）（IIc）（IId）中的基团及其用于治疗病症的药物 和疾病，特别是肺疾病如哮喘和COPD以及疼痛疾病。
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