摘要:
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, ═CH—, —CH2—, —O—, —S—, and —NH—; wherein n is 1, 2 or 3; wherein Z is C or N, the other variables are as defined in the claims, as well as in form of their acid addition salts with pharmacologically acceptable acids.
摘要翻译:本发明涉及CCR2(CC趋化因子受体2)的新型拮抗剂及其用于治疗疾病,特别是肺疾病如哮喘和COPD的药物的用途。 式(I)其中A选自单键,-CH =,-CH 2 - , - O - , - S - 和-NH-; 其中n为1,2或3; 其中Z是C或N,其它变量如权利要求中所定义,以及其与药理学上可接受的酸的酸加成盐的形式。
摘要:
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要:
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
摘要:
New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastrointestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
摘要:
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
摘要:
New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
摘要:
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
摘要翻译:一种药物组合物,其包含式1的化合物,其中:n为1或2; R 1是氢,C 1 -C 4 - 烷基,卤素,OH或-OC 1 - C 4 - 烷基; R 2是氢,C 1 -C 4 - 烷基,卤素,OH或-OC 1 - C 4 - 烷基; R 3是氢,C 1 -C 4 - 烷基,OH,卤素,-OC 1 -C - 烷基,-OC 1 -C 4 - 亚烷基-COOH或-OC 1 -C 3 - 或其酸加成盐与药理学上可接受的酸或溶剂化物或其盐或其盐或其盐 水合物; 和药学上可接受的赋形剂或载体,以及使用该药物制剂治疗慢性阻塞性肺疾病(COPD)的方法。
摘要:
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
摘要:
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof, and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
摘要翻译:一种药物组合物,其包含式1的化合物,其中:n为1或2; R 1是氢,C 1 -C 4 - 烷基,卤素,OH或-OC 1 - C 4 - 烷基; R 2是氢,C 1 -C 4 - 烷基,卤素,OH或-OC 1 - C 4 - 烷基; R 3是氢,C 1 -C 4 - 烷基,OH,卤素,-OC 1 -C - 烷基,-OC 1 -C 4 - 亚烷基-COOH或-OC 1 -C 3 - 或其酸加成盐与药理学上可接受的酸或溶剂化物或其盐或其盐或其盐 水合物和药学上可接受的赋形剂或载体,以及使用该药物制剂治疗慢性阻塞性肺病(COPD)的方法。
摘要:
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1–C4-alkyl, halogen, OH, or —O—C1–C4-alkyl; R2 is hydrogen, C1–C4-alkyl, halogen, OH, or —O—C1–C4-alkyl; R3 is hydrogen, C1–C4-alkyl, OH, halogen, —O—C1–C4-alkyl, —O—C1–C4-alkylene-COOH, or —O—C1–C4-alkylene-CO—O—C1–C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
摘要翻译:一种药物组合物,其包含式1的化合物,其中:n为1或2; R 1是氢,C 1 -C 4 - 烷基,卤素,OH或-OC 1 - C 4 - 烷基; R 2是氢,C 1 -C 4 - 烷基,卤素,OH或-OC 1 - C 4 - 烷基; R 3是氢,C 1 -C 4 - 烷基,OH,卤素,-OC 1 -C - 烷基,-OC 1 -C 4 - 亚烷基-COOH或-OC 1 -C 3 - 或其酸加成盐与药理学上可接受的酸或溶剂化物或其盐或其盐或其盐 水合物; 和药学上可接受的赋形剂或载体,以及使用该药物制剂治疗慢性阻塞性肺疾病(COPD)的方法。