公开(公告)号：US20190209706A1

公开(公告)日：2019-07-11

申请号：US16232601

申请日：2018-12-26

Applicant: Industrial Technology Research Institute

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien-Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K31/569 ,  A61K47/38 ,  A61K9/08

CPC classification number: A61K47/6951 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/4439 ,  A61K31/569 ,  A61K47/38 ,  A61K47/40 ,  A61K47/65

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

公开(公告)号：US20240016954A1

公开(公告)日：2024-01-18

申请号：US18471821

申请日：2023-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K47/22 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38

CPC classification number: A61K47/6951 ,  A61K47/22 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38 ,  A61K31/47

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition for improving the solubility of poorly soluble substances includes 60-97% by weight of cyclodextrin and/or a derivative thereof, 0.5-4% by weight of at least one water-soluble polymer and 0.4-30% by weight of at least one water-soluble stabilizer, wherein the at least one water-soluble stabilizer includes caffeine, and wherein the poorly soluble substance is a tyrosine kinase inhibitor.

公开(公告)号：US20220202952A1

公开(公告)日：2022-06-30

申请号：US17560820

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Neng-Chang YU ,  Felice CHENG ,  Chih-Peng LIU ,  Ming-Hsi WU ,  Shih-Ta CHEN ,  Chia-Mu TU ,  Li-Wen CHANG ,  Jheng-Sian LI ,  Meng-Ping SHE ,  Hsiang-Ching WANG

IPC: A61K47/69 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/395 ,  A61P35/00

Abstract: An immunostimulatory lipoplex is provided. The immunostimulatory lipoplex includes a liposome and at least one immunostimulatory nucleic acid drug, and the immunostimulatory nucleic acid drug is complexed with the liposome The liposome includes 40 to 85 mol % of cationic lipid, 10 to 50 mol % of cholesterol, and 0.001 to 20 mol % of modified polyethylene glycol lipid. A pharmaceutical composition including the immunostimulatory lipoplex is also provided

公开(公告)号：US20220202610A1

公开(公告)日：2022-06-30

申请号：US17139360

申请日：2020-12-31

Applicant: Industrial Technology Research Institute

Inventor： Felice CHENG ,  Wen-Chia HUANG ,  Shao-Chan YIN ,  Po-Hsien KUO ,  Li-Wen CHANG ,  Yen-Jen WANG

IPC: A61F9/00 ,  G02B1/04 ,  C08B37/16 ,  C08G83/00 ,  C08F220/18 ,  C08F220/20 ,  C08F222/10

Abstract: A contact lens with sustained-release property is provided. The contact lens includes a polymer, pseudorotaxane embedded in the polymer, and a stabilizer embedded in the pseudorotaxane. The polymer is polymerized by monomer materials. The monomer materials include ethyl methacrylate, ethylene glycol dimethacrylate, methacrylic acid, 2-hydroxyethyl methacrylate, or a combination thereof. The stabilizer includes surfactant, amino acid with a polar side chain, oligopeptide containing at least one amino acid with a polar side chain, purine or its derivative, or a combination thereof.

公开(公告)号：US20180110731A1

公开(公告)日：2018-04-26

申请号：US15788920

申请日：2017-10-20

Applicant: Industrial Technology Research Institute

Inventor： Wen-Hsuan CHIANG ,  Yu-Wen LO ,  Felice CHENG ,  Maggie LU ,  Ya-Ling CHIU

IPC: A61K9/06 ,  A61K47/10 ,  A61K47/34 ,  C07K16/32 ,  A61K33/30 ,  A61K39/395 ,  A61K38/26 ,  A61K38/38 ,  A61K38/17 ,  A61K31/704

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/704 ,  A61K33/30 ,  A61K38/1793 ,  A61K38/26 ,  A61K38/385 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/10 ,  A61K47/34 ,  A61K47/42 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/94

Abstract: A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.

公开(公告)号：US20150111834A1

公开(公告)日：2015-04-23

申请号：US14488431

申请日：2014-09-17

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Felice CHENG ,  Maggie J.M. LU ,  Yi-Ju KO ,  Min-Ying LIN ,  Shuen-Hsiang CHOU

IPC: A61K47/42 ,  A61K9/00 ,  A61K47/22 ,  A61K47/36 ,  A61K47/18

CPC classification number: A61K9/0048 ,  A61K9/0024 ,  A61K31/00 ,  A61K47/36

Abstract: The disclosure provides a recipe for in-situ gel, formed by dissolving at least one polymer and at least one gel prevention agent in a polar solvent to form a solution and placing the solution in a condition for in-situ forming gels. The disclosure also provides an implant and a drug delivery system formed by the recipe.

Abstract translation: 本公开提供了通过将至少一种聚合物和至少一种凝胶预防剂溶解在极性溶剂中形成溶液并将溶液置于用于原位形成凝胶的条件下形成的原位凝胶的配方。 本公开还提供了通过该配方形成的植入物和药物递送系统。