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公开(公告)号：US09968563B2
公开(公告)日：2018-05-15
申请号：US15187385
申请日：2016-06-20
Applicant: JGC CORPORATION , INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Yasuaki Ogawa , Naoki Tahara , Tomoya Yamashita , Shuzo Kojima , Felice Cheng , Sung-En Chen , Jui-Mei Lu
CPC classification number: A61K9/5089 , A61K9/19 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K38/00 , A61K38/1793
Abstract: An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.
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Patent Agency Ranking
公开(公告)号：US10398647B2
公开(公告)日：2019-09-03
申请号：US15788920
申请日：2017-10-20
Applicant: Industrial Technology Research Institute
Inventor： Wen-Hsuan Chiang , Yu-Wen Lo , Felice Cheng , Maggie Lu , Ya-Ling Chiu
IPC: A61K9/06 , A61K47/10 , A61K47/34 , A61K31/704 , A61K38/38 , A61K38/17 , C07K16/32 , A61K39/395 , A61K38/26 , A61K33/30 , A61K47/42 , A61K39/00 , A61K9/00
Abstract: A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.
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公开(公告)号：US11801310B2
公开(公告)日：2023-10-31
申请号：US16232601
申请日：2018-12-26
Applicant: Industrial Technology Research Institute
Inventor： Wen-Chia Huang , Yen-Jen Wang , Felice Cheng , Chia-Ching Chen , Shao-Chan Yin , Chien-Lin Pan , Tsan-Lin Hu , Meng-Nan Lin , Kuo-Kuei Huang , Maggie Lu , Chih-Peng Liu
IPC: A61K47/69 , A61K47/38 , A61K47/40 , A61K31/4439 , A61K31/569 , A61K9/00 , A61K47/65 , A61K9/08
CPC classification number: A61K47/6951 , A61K9/0019 , A61K9/0048 , A61K9/0053 , A61K9/08 , A61K31/4439 , A61K31/569 , A61K47/38 , A61K47/40 , A61K47/65
Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.
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公开(公告)号：US20170056330A1
公开(公告)日：2017-03-02
申请号：US15187385
申请日：2016-06-20
Applicant: JGC CORPORATION , INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Yasuaki Ogawa , Naoki Tahara , Tomoya Yamashita , Shuzo Kojima , Felice Cheng , Sung-En Chen , Jui-Mei Lu
CPC classification number: A61K9/5089 , A61K9/19 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K38/00 , A61K38/1793
Abstract: [Object] An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.[Method for Achieving the Object] The present invention provides a method for producing a microcapsule formulation comprising: step A of adding a basic amino acid to an aqueous solvent containing a heavy metal salt of a peptidic physiologically active substance to obtain an amino acid-containing S/W suspension; step B of adding a basic amino acid to an organic solvent containing a biodegradable polymer to obtain an amino acid-containing polymer solution; step C of dispersing the amino acid-containing S/W suspension in the amino acid-containing polymer solution, which is an oil phase, to obtain an S/W/O emulsion; step D of dispersing the S/W/O emulsion in a water phase to obtain an S/W/O/W emulsion; and step E of removing the organic solvent from the S/W/O/W emulsion.
Abstract translation: 本发明提供了一种微胶囊制剂的制备方法，其包括：步骤A，将碱性氨基酸加入含有肽生理活性物质的重金属盐的含水溶剂中，得到含氨基酸的S / W悬浮液; 向含有生物降解性聚合物的有机溶剂中添加碱性氨基酸的步骤B，得到含氨基酸的聚合物溶液; 将含有氨基酸的S / W悬浮液分散在作为油相的含氨基酸的聚合物溶液中以获得S / W / O乳液的步骤C; 步骤D将S / W / O乳液分散在水相中以获得S / W / O / W乳液; 和从S / W / O / W乳液中除去有机溶剂的步骤E. 该方法能够避免肽生理活性物质与有机溶剂层的直接接触，并且实现肽生理活性物质的高包封效率。
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5.发明公开公开(公告)号：US20240189243A1
公开(公告)日：2024-06-13
申请号：US18507536
申请日：2023-11-13
Applicant: Industrial Technology Research Institute
Inventor： Felice Cheng , Ping-Fu Cheng , Jenn-Tsang Hwang , Chih-Wei Fu , Ku-Feng Lin , Ya-Ling Chiu , Jheng-Sian Li , Kang-Li Wang , Siou-Han Chang , Chia-Yu Fan
IPC: A61K9/51 , A61K31/7105 , A61K31/711 , A61K47/28 , C07F9/09 , C07F9/535 , C07F9/6509 , C07F9/6512
CPC classification number: A61K9/5123 , A61K31/7105 , A61K31/711 , A61K47/28 , C07F9/091 , C07F9/535 , C07F9/650952 , C07F9/6512
Abstract: A lipid compound or a derivative thereof and a pharmaceutical composition employing the same are provided. The lipid compound has a structure represented by Formula (I):
wherein Z1, Z2, Z3 and Z4 are as disclosed in the specification.-
公开(公告)号：US09757330B2
公开(公告)日：2017-09-12
申请号：US14488431
申请日：2014-09-17
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Felice Cheng , Maggie J. M. Lu , Yi-Ju Ko , Min-Ying Lin , Shuen-Hsiang Chou
CPC classification number: A61K9/0048 , A61K9/0024 , A61K31/00 , A61K47/36
Abstract: The disclosure provides a recipe for in-situ gel, formed by dissolving at least one polymer and at least one gel prevention agent in a polar solvent to form a solution and placing the solution in a condition for in-situ forming gels. The disclosure also provides an implant and a drug delivery system formed by the recipe.
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