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公开(公告)号:US20220169808A1
公开(公告)日:2022-06-02
申请号:US17537728
申请日:2021-11-30
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Wei-Hong CHANG , Ching-Mei CHEN , Grace H. CHEN , Hsin-Hsin SHEN , Yuchi WANG , Ming-Chia YANG , Li-Hsin LIN , Sen-Lu CHEN , Yi-Hsuan LEE , Jian-Wei LIN , Liang-Cheng SU
Abstract: An anti-curling film is provided. The anti-curling film includes a first portion and a second portion covering the first portion. The first portion includes polylactic acid (PLA), polycaprolactone (PCL), polyethylene glycol dimethacrylate (PEGDMA) and a photoinitiator. The second portion includes polycaprolactone (PCL), gelatin, hyaluronic acid (HA), alginate (AA), polyvinyl alcohol (PVA) or a combination thereof.
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公开(公告)号:US20210322625A1
公开(公告)日:2021-10-21
申请号:US17308547
申请日:2021-05-05
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Hsin-Hsin SHEN , Ming-Chia YANG , Chia-Chi HO , Fang-Jie JANG , Che-Yu OU , Chi-Hsiang LIAO , Brian HSU , Tai-Horng YOUNG
Abstract: The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.
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公开(公告)号:US20210196648A1
公开(公告)日:2021-07-01
申请号:US16731979
申请日:2019-12-31
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Hsin SHEN , Yuchi WANG , Li-Hsin LIN , Ming-Chia YANG , Hsiu-Hua HUANG , Liang-Cheng SU , Ying-Hsueh CHAO , Jing-En HUANG
IPC: A61K9/70
Abstract: A drug-containing multilayer film provided. The drug-containing multilayer film includes: a drug-containing layer; and an anti-adhesion layer on a surface of the drug-containing layer. The drug-containing layer is composed of a first composition including a first polymer material and a drug, and the first polymer material includes at least one selected from the group consisting of: polylactic acid (PLA) and polyethylene glycol (PEG), and the weight ratio of the first polymer material to the drug is about 1:0.01-0.3. The anti-adhesion layer is composed of a second composition, and the second composition includes a second polymer material, and the second polymer material includes at least one selected from the group consisting of polylactic acid and polyethylene glycol.
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公开(公告)号:US20190076234A1
公开(公告)日:2019-03-14
申请号:US16122438
申请日:2018-09-05
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Yu-Bing LIOU , Ming-Chia YANG , Hsin-Yi HSU , Yun-Han LIN , Wei-Hong CHANG , I-Jong WANG , Hsin-Hsin SHEN
Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.
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公开(公告)号:US20180185542A1
公开(公告)日:2018-07-05
申请号:US15394001
申请日:2016-12-29
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Hsin SHEN , Ming-Chia YANG , Chia-Chi HO , Fang-Jie JANG , Che-Yu OU , Chi-Hsiang LIAO , Brian HSU , Tai-Horng YOUNG
CPC classification number: A61L31/146 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/416 , C08J5/18 , C08J2367/04 , C08J2467/02 , C08L67/04
Abstract: The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.
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公开(公告)号:US20180169295A1
公开(公告)日:2018-06-21
申请号:US15388980
申请日:2016-12-22
Applicant: Industrial Technology Research Institute
Inventor: Ming-Chia YANG , Wei-Hong CHANG , Yun-Han LIN , Kun-Mao KUO , Li-Jie LIN , Tai-Horng YOUNG
IPC: A61L24/04
CPC classification number: A61L24/043 , Y02P20/149 , C08L67/04 , C08L5/04
Abstract: The present disclosure provides a film composed of a polymer mixture, wherein the polymer mixture includes: a hydrophobic composition including polycaprolactone (PCL); and at least one hydrophilic polymer selected from a group consisting of: alginate, gelatin, chitosan, hyaluronic acid, collagen, demineralized bone matrix (DSM), carboxymethyl cellulose (CMC), fibrin, polyoxyethylene, polyethylene glycol (PEG) and polyvinylpyrrolidone, wherein the weight ratio of the hydrophobic composition to the at least one hydrophilic polymer is about 1:0.01-100, and wherein the film has the effect of preventing leakage from a surgical wound or a diffuse wound.
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公开(公告)号:US20220388293A1
公开(公告)日:2022-12-08
申请号:US17885874
申请日:2022-08-11
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Hsin SHEN , Yu-Chi WANG , Ming-Chia YANG , Yu-Bing LIOU , Wei-Hong CHANG , Yun-Han LIN , Hsin-Yi HSU , Yun-Chung TENG , Chia-Jung LU , Yi-Hsuan LEE , Jian-Wei LIN , Kun-Mao KUO , Ching-Mei CHEN
Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer, and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution is composed of a second hydrophilic solution.
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公开(公告)号:US20200247101A1
公开(公告)日:2020-08-06
申请号:US16675838
申请日:2019-11-06
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Hsin SHEN , Yu-Chi WANG , Ming-Chia YANG , Yu-Bing LIOU , Wei-Hong CHANG , Yun-Han LIN , Hsin-Yi HSU , Yun-Chung TENG , Chia-Jung LU , Yi-Hsuan LEE , Jian-Wei LIN , Kun-Mao KUO , Ching-Mei CHEN
Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer; and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution 1:0.01-1. Moreover, the second polymer solution consists of a second hydrophilic solution.
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公开(公告)号:US20180200403A1
公开(公告)日:2018-07-19
申请号:US15850902
申请日:2017-12-21
Applicant: Industrial Technology Research Institute
Inventor: Wei-Hong CHANG , Ming-Chia YANG , Yun-Han LIN , Kun-Mao KUO , Yu-Chi WANG , Hsin-Hsin SHEN , Li-Jie LIN
CPC classification number: A61L24/043 , A61B17/04 , A61B17/06166 , A61B17/1114 , A61B2017/00004 , A61B2017/00526 , A61B2017/00575 , A61B2017/00597 , A61B2017/00659 , A61B2017/00818 , A61B2017/00938 , A61B2017/00942 , A61B2017/00964 , A61B2017/0495 , A61B2017/1132 , A61F13/15 , A61L24/0042 , A61L24/0084 , A61L24/0094 , C08L67/04
Abstract: The present disclosure provides a film composed of a polymer mixture, wherein the polymer mixture includes: a hydrophobic composition including polycaprolactone (PCL); and at least one hydrophilic polymer selected from a group consisting of alginate, gelatin, hyaluronic acid, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), collagen, demineralized bone matrix (DBM), bone morphogenetic protein (BMP), albumin, chitosan, fibrin, polyoxyethylene, polyvinylpyrrolidone, wherein the weight ratio of the hydrophobic composition to the hydrophilic polymer is about 1:0.01-100, and wherein the film has the effect of preventing leakage from a surgical wound or a diffuse wound.
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