公开(公告)号：US20030153638A1

公开(公告)日：2003-08-14

申请号：US10000654

申请日：2001-11-01

Applicant: Industrial Technology Research Institute

Inventor： Huey-Min Lai ,  Kuang-Rong Lee ,  Chin-Chin Tsai ,  Hsi-Hsin Shih ,  Yuan-Chia Chang

IPC: C08J009/00

CPC classification number: C08J9/40 ,  C08J3/24 ,  C08J9/405 ,  C08J2201/032 ,  C08J2203/08 ,  Y02P20/544

Abstract: The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the chamber to effect crosslinking of the porous biodegradable polymer; and optionally (c) introducing a pure supercritical into the chamber to wash the crosslinked polymer until the crosslinking agent is substantially removed from the polymer.

公开(公告)号：US20020086977A1

公开(公告)日：2002-07-04

申请号：US10083242

申请日：2001-10-19

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Huey-Min Lai ,  Chun-Hui Chang ,  Chun-Jen Liao ,  Chin-Fu Chen ,  Kuei-Hung Wu ,  Yuan-Chia Chang ,  Yu-Yen Jan ,  Tsung-Yi Mou

IPC: A61K035/14 ,  C07K016/00 ,  C09H001/00 ,  A61K038/17 ,  C07K017/00 ,  C07K014/00 ,  C07K001/00 ,  A61K038/00 ,  A61K038/16

CPC classification number: C08L5/08 ,  C07K17/08 ,  C08B37/003 ,  C08H1/06 ,  C08J9/26 ,  C08J2201/0462 ,  C08L89/06 ,  C08L2666/02

Abstract: The present invention discloses a method for preparing a hydrophilic porous polymeric material comprising the step of mixing a hydrophilic polymeric material with a hydrophobic material; solvent sintering the surface of the hydrophilic polymeric material with water or an aqueous solution; and removing the hydrophobic material contained within the hydrophilic polymeric material with a massive organic solvent. Thus, the hydrophilic porous polymeric material with high porosity and stable structure is rapidly mass produced.

Abstract translation: 本发明公开了一种制备亲水性多孔聚合材料的方法，包括将亲水聚合物与疏水性材料混合的步骤; 溶剂用水或水溶液烧结亲水性聚合物材料的表面; 并用大量有机溶剂除去亲水性聚合物材料中所含的疏水材料。 因此，快速大量生产具有高孔隙率和稳定结构的亲水性多孔聚合材料。

公开(公告)号：US20030064156A1

公开(公告)日：2003-04-03

申请号：US09947182

申请日：2001-09-04

Applicant: Industrial Technology Research Institute

Inventor： Hsi-Hsin Shih ,  Kuang-Rong Lee ,  Huey-Min Lai ,  Chin-Chin Tsai ,  Yuan-Chia Chang

IPC: B05D003/10

CPC classification number: C08J9/122 ,  A61L27/56 ,  A61L27/58 ,  C08J2201/032 ,  C08J2203/06 ,  C08J2203/08 ,  C08J2389/00 ,  Y02P20/544

Abstract: A method of making a porous biodegradable polymer is disclosed, which comprises (a) placing a biodegradable polymer and a solvent in a chamber; (b) adding a supercritical fluid to the chamber and maintaining the chamber at a predetermined temperature for a sufficient period of time to allow the supercritical fluid to dissolve into the biodegradable polymer with the help of the solvent; and (c) venting the supercritical fluid and the solvent by reducing the pressure in the chamber, thereby obtaining a porous biodegradable polymer.

Abstract translation: 公开了制备多孔生物可降解聚合物的方法，其包括（a）将可生物降解的聚合物和溶剂置于室中; （b）将超临界流体加入到室中并将室维持在预定温度足够的时间以允许超临界流体借助溶剂溶解到可生物降解的聚合物中; 和（c）通过降低室中的压力来排出超临界流体和溶剂，从而获得多孔生物可降解聚合物。