公开(公告)号：US20170209519A1

公开(公告)日：2017-07-27

申请号：US15416304

申请日：2017-01-26

Applicant: Industrial Technology Research Institute

Inventor： Kuo-Kuei HUANG ,  I-Horng PAN ,  Meng-Nan LIN ,  Jir-Mehng LO ,  Jennline SHEU ,  Pei-Ru LIAU ,  Yi-Cheng CHENG

IPC: A61K36/9064 ,  A61K9/00 ,  A61K31/11

CPC classification number: A61K36/9064 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0053 ,  A61K9/0073 ,  A61K31/11 ,  A61K2236/333

Abstract: A pharmaceutical composition for treating or alleviating autoimmune-related diseases is provided, including an extract of Amomum tsao-ko as an active ingredient and a pharmaceutically acceptable carrier, in which the extract comprises Vanillin, Tsaokoin, or the combination thereof.

公开(公告)号：US20190209706A1

公开(公告)日：2019-07-11

申请号：US16232601

申请日：2018-12-26

Applicant: Industrial Technology Research Institute

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien-Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K31/569 ,  A61K47/38 ,  A61K9/08

CPC classification number: A61K47/6951 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/4439 ,  A61K31/569 ,  A61K47/38 ,  A61K47/40 ,  A61K47/65

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

公开(公告)号：US20240016954A1

公开(公告)日：2024-01-18

申请号：US18471821

申请日：2023-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wen-Chia HUANG ,  Yen-Jen WANG ,  Felice CHENG ,  Chia-Ching CHEN ,  Shao-Chan YIN ,  Chien Lin PAN ,  Tsan-Lin HU ,  Meng-Nan LIN ,  Kuo-Kuei HUANG ,  Maggie LU ,  Chih-Peng LIU

IPC: A61K47/69 ,  A61K47/22 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38

CPC classification number: A61K47/6951 ,  A61K47/22 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/40 ,  A61K47/38 ,  A61K31/47

Abstract: A composition for improving the solubility of poorly soluble substances is provided. The composition for improving the solubility of poorly soluble substances includes 60-97% by weight of cyclodextrin and/or a derivative thereof, 0.5-4% by weight of at least one water-soluble polymer and 0.4-30% by weight of at least one water-soluble stabilizer, wherein the at least one water-soluble stabilizer includes caffeine, and wherein the poorly soluble substance is a tyrosine kinase inhibitor.

公开(公告)号：US20190000776A1

公开(公告)日：2019-01-03

申请号：US16023940

申请日：2018-06-29

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  Shu-Fang WEN ,  Meng-Nan LIN ,  I-Huang LU ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Tze-Chung LEE ,  Ya-Yan YANG ,  Jia-Horng LIAW

IPC: A61K31/047 ,  A61K31/222 ,  A61K31/075 ,  A61K31/122 ,  A61K31/343 ,  A61K9/14 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40 ,  A61P25/28 ,  A61P37/00

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, —SO2CH3, —(C═O)—CH3 or —(C═O)—NH2.

公开(公告)号：US20230061259A1

公开(公告)日：2023-03-02

申请号：US17977541

申请日：2022-10-31

Applicant: Industrial Technology Research Institute

Inventor： Kuo-Kuei HUANG ,  I-Horng PAN ,  Meng-Nan LIN ,  Jir-Mehng LO ,  Jennline SHEU ,  Pei-Ru LIAU ,  Yi-Cheng CHENG ,  Pei-Hsin LIN

IPC: A61K36/9064 ,  A61K31/11 ,  A61K9/00

Abstract: A method of treating or alleviating autoimmune-related diseases is provided. The method includes administering a pharmaceutical composition to a subject in need thereof. Moreover, the pharmaceutical composition includes an extract of Amomum tsao-ko as an effective ingredient and a pharmaceutically acceptable carrier or salt.

公开(公告)号：US20220249395A1

公开(公告)日：2022-08-11

申请号：US17727301

申请日：2022-04-22

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  Shu-Fang WEN ,  Meng-Nan LIN ,  I-Huang LU ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Tze-Chung LEE ,  Ya-Yan YANG ,  Jia-Horng LIAW ,  Pei-Hsin LIN

IPC: A61K31/047 ,  A61K31/215 ,  A61K31/335 ,  A61K9/50 ,  A61K31/352 ,  A61K9/00 ,  A61K31/045 ,  A61P37/00 ,  A61P25/28 ,  A61K9/08 ,  A61K9/14 ,  A61K31/075 ,  A61K31/122 ,  A61K31/222 ,  A61K31/343 ,  A61K47/02 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, Z is O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, O2CH3, —(C═O)—CH3 or (C═O)—NH2.