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公开(公告)号:US20250145632A1
公开(公告)日:2025-05-08
申请号:US18721125
申请日:2022-12-21
Applicant: INSILICO MEDICINE IP LIMITED
Inventor: Hongfu LU , Jingjing PENG , Xiao DING , Jinxin LIU , Yingtao LIU , Feng REN , Fusheng ZHOU , Tao JIANG , Tao LIANG , Jiong LAN , Qiang LU
IPC: C07D487/22 , A61K31/519 , A61K31/675 , A61P35/00 , C07D471/22 , C07D487/16 , C07D498/16 , C07D498/22 , C07D519/00 , C07F9/6561
Abstract: The present invention discloses a pyrimidine heterocyclic compound, and a preparation method and medical use thereof. Specifically, the present invention discloses a pyrimidine heterocyclic compound with a structure shown in Formula (A) or a pharmaceutically acceptable salt thereof (groups are each defined in the specification), a pharmaceutical composition comprising the compound, and use of the compound in treatment of cell proliferative diseases (such as cancers).
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公开(公告)号:US20240116935A1
公开(公告)日:2024-04-11
申请号:US18507595
申请日:2023-11-13
Applicant: Insilico Medicine IP Limited
Inventor: Hongfu LU , Huaxing YU , Xiao DING , Feng REN
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Described herein are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.
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公开(公告)号:US20240051958A1
公开(公告)日:2024-02-15
申请号:US18486374
申请日:2023-10-13
Applicant: Insilico Medicine IP Limited
Inventor: Hongfu LU , Huaxing YU , Xiao DING , Feng REN
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Described herein are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.
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