-
1.发明申请Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的新型双环脲衍生物公开(公告)号：US20050038031A1
公开(公告)日：2005-02-17
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
-
2.发明授权Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的双环脲衍生物公开(公告)号：US08076488B2
公开(公告)日：2011-12-13
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： C07D213/62 , C07D401/00 , C07D417/00
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
-
3.发明授权Cyanopyridine derivatives useful in the treatment of cancer and other disorders 有权可用于治疗癌症和其他疾病的氰基吡啶衍生物公开(公告)号：US07557129B2
公开(公告)日：2009-07-07
申请号：US10788029
申请日：2004-02-27
申请人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
发明人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
IPC分类号： A61K31/4433 , C07D405/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
-
4.发明申请SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 审中-公开用于治疗癌症和其他疾病的替代吡啶衍生物公开(公告)号：US20100075971A1
公开(公告)日：2010-03-25
申请号：US12628735
申请日：2009-12-01
申请人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
发明人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
IPC分类号： A61K31/4412 , C07D211/74 , C07D405/12 , C07D401/12 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/4433 , A61K31/4709 , A61K31/4439 , A61K31/4545 , A61K31/5377
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
-
5.发明授权Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号：US07351735B2
公开(公告)日：2008-04-01
申请号：US10501689
申请日：2003-02-21
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号： A61K31/343 , A61K31/381 , C07D307/80 , C07D333/56
CPC分类号： C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要： This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
摘要翻译： 本发明涉及一般表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途
-
![Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases](/abs-image/US/2013/04/30/US08431695B2/abs.jpg.150x150.jpg)
6.发明授权Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases 失效吡咯并[2,1-f] [1,2,4]三嗪-4-基胺治疗癌症和其他过度增生性疾病的IGF-1R激酶抑制剂公开(公告)号：US08431695B2
公开(公告)日：2013-04-30
申请号：US12084411
申请日：2006-11-02
申请人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号： C07D487/04 , C07D413/02 , C07D417/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译： 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
-
![Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases](/abs-image/US/2011/12/01/US20110294776A1/abs.jpg.150x150.jpg)
7.发明申请Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases 失效吡咯并[2,1-F] [1,2,4]三嗪-4-基胺IGF-1R激酶抑制剂治疗癌症和其他过度增生性疾病公开(公告)号：US20110294776A1
公开(公告)日：2011-12-01
申请号：US12084411
申请日：2006-11-02
申请人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号： A61K31/53 , C07D498/04 , A61P35/00 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译： 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
-
公开(公告)号：US20070244120A1
公开(公告)日：2007-10-18
申请号：US11768112
申请日：2007-06-25
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号： A61K31/5377 , A61K31/09 , A61K31/136 , A61K31/381 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/426 , C07D401/12 , C07D231/10 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号： C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
-
9.发明授权Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders 失效可用于治疗癌症和其他疾病的取代嘧啶衍生物公开(公告)号：US08580798B2
公开(公告)日：2013-11-12
申请号：US12158524
申请日：2006-12-20
申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
发明人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
IPC分类号： C07D401/12 , A61K31/506
CPC分类号： C07D401/12
摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.
摘要翻译： 式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗 增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。
-
10.发明申请SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 失效用于治疗癌症和其他疾病的替代吡嗪衍生物公开(公告)号：US20100081812A1
公开(公告)日：2010-04-01
申请号：US12158524
申请日：2006-12-20
申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
发明人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.
摘要翻译： 式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗 增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。
-
-
-
-
-
-
-
-
-
搜索结果
66 条记录 (耗时 0.075 秒)
