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公开(公告)号：US08876795B2
公开(公告)日：2014-11-04
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译： 一种用于在一段时间内将药物输送到患者身体的体液中的可植入药物递送设备包括：药物供应储存器，用于将药物供应到输送通道中;以及致动器，用于将药物输送到患者的预定位置 患者的身体腔，例如人耳的耳蜗。 药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。
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公开(公告)号：US20130053823A1
公开(公告)日：2013-02-28
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译： 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括：药物供应储存器，用于将药物供给到输送通道中;以及致动器，用于将药物输送到患者的预定位置 患者的身体腔，例如人耳的耳蜗。 药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。
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公开(公告)号：US20110295194A1
公开(公告)日：2011-12-01
申请号：US12986067
申请日：2011-01-06
CPC分类号： A61F11/002 , A61M5/14216 , A61M5/14224 , A61M5/14276 , A61M31/002 , A61M2205/0244 , A61M2210/0662 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
摘要翻译： 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括限定用于接收药物并再循环治疗流体的工作室的可变容积容器。 流体可以包含体液，例如外淋巴液和药物。 该装置允许将治疗流体受控地输送到患者体腔中的预定位置，例如人耳的耳蜗。
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公开(公告)号：US09180054B2
公开(公告)日：2015-11-10
申请号：US12986067
申请日：2011-01-06
CPC分类号： A61F11/002 , A61M5/14216 , A61M5/14224 , A61M5/14276 , A61M31/002 , A61M2205/0244 , A61M2210/0662 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
摘要翻译： 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括限定用于接收药物并再循环治疗流体的工作室的可变容积容器。 流体可以包含体液，例如外淋巴液和药物。 该装置允许将治疗流体受控地输送到患者体腔中的预定位置，例如人耳的耳蜗。
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公开(公告)号：US07867193B2
公开(公告)日：2011-01-11
申请号：US11046540
申请日：2005-01-28
申请人： Michael J. McKenna , Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , William F. Sewell , Anthony A. Mikulec
发明人： Michael J. McKenna , Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , William F. Sewell , Anthony A. Mikulec
CPC分类号： A61M5/14276 , A61F11/00 , A61M5/14224 , A61M5/1723 , A61M31/002 , A61M2205/0244 , A61M2205/3379 , A61M2210/0662 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic fluid through the lumen. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The apparatus also includes a pump, for example a single unidirectional pump, to control the flow rate of the therapeutic fluid through the hollow member, and an interface member in communication with at least one lumen of the hollow member. The device thus allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
摘要翻译： 一种可植入药物输送装置，用于将药物输送到患者体腔中的体液一段时间，该时间段包括限定至少一个内腔的中空构件，以便于治疗流体通过内腔的单向循环流动 。 流体可以包含体液，例如外淋巴液和药物。 该装置还包括泵，例如单个单向泵，以控制通过中空构件的治疗流体的流速，以及与中空构件的至少一个内腔连通的界面构件。 因此，该装置允许治疗性流体的受控输送到患者体腔中的预定位置，例如人耳的耳蜗。
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6.发明授权Method and apparatus for separating particles, cells, molecules and particulates 有权用于分离颗粒，细胞，分子和颗粒的方法和装置公开(公告)号：US08292083B2
公开(公告)日：2012-10-23
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B03C1/30
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译： 一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废流体的磁场梯度，以及在流过磁场梯度之后收集每个流体流。
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7.发明申请METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 有权分离颗粒，细胞，分子和颗粒的方法和装置公开(公告)号：US20090078614A1
公开(公告)日：2009-03-26
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B07C5/344
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译： 一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废液流的磁场梯度，以及在流过磁场梯度之后收集每个流体流。
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公开(公告)号：US09006149B2
公开(公告)日：2015-04-14
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
摘要： A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.
摘要翻译： 高通量流量系统包括井阵列和位于每个井内的单独机械末端。 每个机械末端分别致动以赋予剪切应力模式。 单独的套筒可以与每个尖端相关联，以保持尖端与尖端相应的井的底板之间的预定距离，每个尖端可在其对应的套筒内旋转。 或者，单独的柱可以与每个末端相关联，以保持尖端与尖端相应的井的底部之间的预定距离，其中每个尖端可围绕其相应的柱转动。
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公开(公告)号：US20100323916A1
公开(公告)日：2010-12-23
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adam, JR.
摘要： In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.
摘要翻译： 在一个实施例中，高通量流量系统包括井的阵列和位于每个井内的单独的机械末端。 每个机械末端分别致动以赋予剪切应力模式。
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公开(公告)号：US09046192B2
公开(公告)日：2015-06-02
申请号：US12023653
申请日：2008-01-31
申请人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
发明人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
CPC分类号： F16K99/0015 , A61M5/141 , A61M5/14276 , A61M5/16809 , A61M5/16813 , A61M31/002 , A61M39/22 , A61M2039/226 , A61M2205/0244 , A61M2206/22 , F16K99/0001 , F16K99/0034 , F16K99/0042 , F16K99/0055 , F16K2099/0069 , F16K2099/0076 , F16K2099/008 , F16K2099/0088 , G05D7/0113 , G05D7/012 , Y10T137/0318 , Y10T137/0396
摘要： A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.
摘要翻译： 微流体装置可以包括限定流量控制腔的衬底和与流量控制腔流体连通的第一和第二通道。 用于调节通过流动控制腔的流体流动的柔性膜可以围绕流动控制腔的至少一部分。
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