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公开(公告)号：US08691517B2
公开(公告)日：2014-04-08
申请号：US12085961
申请日：2006-12-06
IPC分类号： G01N33/543 , G01N33/542 , G01N33/66 , A61B5/145
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译： 用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分 包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基 部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。
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公开(公告)号：US08700113B2
公开(公告)日：2014-04-15
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译： 用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留 但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。
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公开(公告)号：US08478375B2
公开(公告)日：2013-07-02
申请号：US11792046
申请日：2005-12-07
IPC分类号： A61B5/1455 , C12Q1/68
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译： 用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分 分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。
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公开(公告)号：US20090131773A1
公开(公告)日：2009-05-21
申请号：US11792046
申请日：2005-12-07
IPC分类号： A61B5/1459 , A61B5/145
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译： 用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分 分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。
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公开(公告)号：US20090187084A1
公开(公告)日：2009-07-23
申请号：US12085961
申请日：2006-12-06
IPC分类号： A61B5/1455 , G01N33/53 , C07H15/00
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译： 用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分 包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基 部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。
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公开(公告)号：US20080188723A1
公开(公告)日：2008-08-07
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svennin Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svennin Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译： 用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留 但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。
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公开(公告)号：US09149737B2
公开(公告)日：2015-10-06
申请号：US13496006
申请日：2010-09-16
CPC分类号： A61K31/74 , B01D15/1807 , B01D15/3804 , B01J20/26 , B01J20/268
摘要： Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible. Also disclosed is a method for treatment, amelioration or prophylaxis of a disease selected from the group consisting of phenylketonuria (PKU, Følling's disease), hyperphenylalaninemia (HPA), alcaptonuria (black urine disease), tyrosinemia, hypertyrosinemia, myasthenia gravis, histidinemia, urocanic aciduria, maple syrup urine disease (MSUD), isovaleric acidemia (isovaleryl-CoA dehydrogenase deficiency), homocystinuria, propionic acidemia, methylmalonic acidemia, and glutaric aciduria Type 1 (GA-I), galactosemia, comprising administering to the gastrointestinal tract of a patient in need thereof an effective amount of a composition of molecular imprinted polymers (MIPs), said composition being capable of binding a symptom provoking agent of said disease.
摘要翻译： 公开了一种制备富含结合试剂的受体（通常是分子侵入聚合物，MIP）的组合物的方法，其中所述受体各自特异性结合所述试剂上的至少两个离散位点，通过使受体样品经受第一步 与试剂亲和纯化，其中试剂上的一个结合位点不能与受体结合，然后使纯化的受体与试剂上的第二结合位点不相容的至少一个进一步的亲和纯化步骤进行， 无障碍。 还公开了治疗，改善或预防选自苯丙酮尿症（PKU，Følling氏病），高苯丙氨酸血症（HPA），尿酸血症（黑尿病），酪氨酸血症，高铁血症，重症肌无力，组氨酸血症，尿路感染 酸尿，枫糖尿病（MSUD），异戊酸 - 异丙酰脱氢酶缺乏症，同型胱尿蛋白尿，丙酸血症，甲基丙二酸血症和戊二酸1型糖尿病（GA-I），半乳糖血症，包括给予患者胃肠道 在有需要的情况下，有效量的分子印迹聚合物（MIP）的组合物，所述组合物能够结合所述疾病的症状发作剂。
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公开(公告)号：US20150031779A1
公开(公告)日：2015-01-29
申请号：US14379913
申请日：2012-02-28
IPC分类号： C08J9/36
CPC分类号： C08J9/36 , B01D15/3804 , B01D15/3852 , B01J20/268 , B01J20/285 , B01J20/3007 , B01J20/3057 , B01J20/3085 , B01J2220/82 , B82Y30/00 , C08J2300/00
摘要： Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising: a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.
摘要翻译： 提供了一种用于制备不溶性分子印迹聚合物（MIP）的改进方法，所述方法包括：a）提供可溶性或半溶性MIP，其1）基本上全部结合模板剂和2）具有使其能够在色谱步骤中分离的尺寸 使用填充床层析法，b）交联在步骤a中提供的结合可溶性MIP的模板剂，以获得结合MIP的不溶性模板剂，以及c）任选分离，浓缩或纯化通过步骤b中的交联获得的MIP 。 在有趣的实施方案中，步骤a包括亲和纯化程序，其确保步骤a中提供的MIP确实是模板的所有结合物。
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公开(公告)号：US20120171154A1
公开(公告)日：2012-07-05
申请号：US13496006
申请日：2010-09-16
IPC分类号： A61K39/395 , A61P13/02 , A61K31/74
CPC分类号： A61K31/74 , B01D15/1807 , B01D15/3804 , B01J20/26 , B01J20/268
摘要： Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible. Also disclosed is a method for treatment, amelioration or prophylaxis of a disease selected from the group consisting of phenylketonuria (PKU, Følling's disease), hyperphenylalaninemia (HPA), alcaptonuria (black urine disease), tyrosinemia, hypertyrosinemia, myasthenia gravis, histidinemia, urocanic aciduria, maple syrup urine disease (MSUD), isovaleric acidemia (isovaleryl-CoA dehydrogenase deficiency), homocystinuria, propionic acidemia, methylmalonic acidemia, and glutaric aciduria Type 1 (GA-I), galactosemia, comprising administering to the gastrointestinal tract of a patient in need thereof an effective amount of a composition of molecular imprinted polymers (MIPs), said composition being capable of binding a symptom provoking agent of said disease.
摘要翻译： 公开了一种制备富含结合试剂的受体（通常是分子侵入聚合物，MIP）的组合物的方法，其中所述受体各自特异性结合所述试剂上的至少两个离散位点，通过使受体样品经受第一步 与试剂亲和纯化，其中试剂上的一个结合位点不能与受体结合，然后使纯化的受体与试剂上的第二结合位点不相容的至少一个进一步的亲和纯化步骤进行， 无障碍。 还公开了治疗，改善或预防选自苯丙酮尿症（PKU，Følling氏病），高苯丙氨酸血症（HPA），尿酸血症（黑尿病），酪氨酸血症，高铁血症，重症肌无力，组氨酸血症，尿路感染 酸尿，枫糖尿病（MSUD），异戊酸 - 异丙酰脱氢酶缺乏症，同型胱尿蛋白尿，丙酸血症，甲基丙二酸血症和戊二酸1型糖尿病（GA-I），半乳糖血症，包括给予患者胃肠道 在有需要的情况下，有效量的分子印迹聚合物（MIP）的组合物，所述组合物能够结合所述疾病的症状发作剂。
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公开(公告)号：US4342727A
公开(公告)日：1982-08-03
申请号：US89520
申请日：1979-10-30
申请人： Karl Janner , Klaus Gregorius
发明人： Karl Janner , Klaus Gregorius
CPC分类号： B01D59/50
摘要： Separation of gaseous isotopes such as UF.sub.6 by adiabatically expanding a gas stream containing the isotopes to cool to a temperature at which condensation or dimers are formed. Selectively exciting by electromagnetic radiation one isotope compound to inhibit condensation or to effect dissociation of dimers containing one isotope compound. Deflecting the flow of the gas stream to effect a change of isotope distribution in the gas stream. Separating by peeling the enriched portion of the gas stream from the remainder depleted portion of the gas stream.
摘要翻译： 通过将含有同位素的气流绝热膨胀至冷凝或二聚体形成的温度来分离气态同位素如UF6。 通过电磁辐射选择性地激发一种同位素化合物，以抑制冷凝或实现含有一种同位素化合物的二聚体的解离。 偏转气流的流动以实现气流中同位素分布的变化。 通过将气流的富集部分从气流的剩余部分去除部分分离。
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