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    Optical Imaging Contrast Agents for Imaging Lung Cancer
    6.
    发明申请
    Optical Imaging Contrast Agents for Imaging Lung Cancer 审中-公开
    用于成像肺癌的光学成像对比剂

    公开(公告)号：US20080044350A1

    公开(公告)日：2008-02-21

    申请号：US10582842

    申请日：2004-12-17

    申请人： Jo Klaveness ,  Edvin Johannesen ,  Helge Tolleshaug

    发明人： Jo Klaveness ,  Edvin Johannesen ,  Helge Tolleshaug

    IPC分类号： A61K49/00 ,  A61P35/00

    CPC分类号： A61K49/0056 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0052

    摘要： The invention provides contrast agents for optical imaging of prostate cancer in patients. The contrast agents may be used in diagnosis of prostate cancer, for follow up of progress in disease development, for follow up of treatment of prostate cancer and for surgical guidance. Further, the invention provides methods for optical imaging of prostate cancer in patients.

    摘要翻译： 本发明提供了用于患者前列腺癌的光学成像的造影剂。 造影剂可用于诊断前列腺癌，用于跟踪疾病发展的进展，后续治疗前列腺癌和手术指导。 此外，本发明提供了患者前列腺癌的光学成像方法。

    Microbubbles surrounded by a monolayer of negatively charged phospholipids as contrast agents
    8.
    发明授权
    Microbubbles surrounded by a monolayer of negatively charged phospholipids as contrast agents 有权
    由单层带负电荷的磷脂包围的微泡作为造影剂

    公开(公告)号：US06221337B1

    公开(公告)日：2001-04-24

    申请号：US09136410

    申请日：1998-08-19

    申请人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

    发明人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

    IPC分类号： A61B800

    CPC分类号： A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  Y10T428/2982

    摘要： Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

    摘要翻译： 主要由包含单独具有整体净电荷的分子的磷脂稳定的微泡分散体显示出有利的稳定性，使其成为有效的造影剂。 还公开了一种用于制备含微泡的造影剂的改进方法，其包括将由一种或多种形成膜的脂质稳定的气体微泡的水性分散体冻干以产生可在可注射载体液体中重构以产生微泡的干燥产物 含有造影剂。

    Optical imaging of endometriosis
    9.
    发明申请
    Optical imaging of endometriosis 审中-公开
    子宫内膜异位症的光学成像

    公开(公告)号：US20070116646A1

    公开(公告)日：2007-05-24

    申请号：US10573604

    申请日：2004-09-28

    申请人： Jo Klaveness ,  Edvin Johannesen ,  Helge Tolleshaug

    发明人： Jo Klaveness ,  Edvin Johannesen ,  Helge Tolleshaug

    IPC分类号： A61K49/00 ,  C07K16/46

    CPC分类号： A61K49/0056 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0052

    摘要： The invention provides contrast agents for optical imaging of endometriosis in patients. The contrast agent may be used in diagnosis of endometriosis, for follow-up of progress in disease development, and for follow-up of treatment of endometriosis. Further, the invention provides methods for optical imaging of endometriosis. The contrast agent has affinity for an abnormally expressed target associated with endometriosis. By abnormally expressed, is meant that the target is either overexpressed or downregulated. Endometriotic tissue containing a downregulated target may be identified by a low amount of bound contrast agent compared to normal tissue. In this situation, the amount of contrast agent should be less than 50% of that in normal tissue, preferably less than 10%.

    摘要翻译： 本发明提供了用于患者子宫内膜异位症的光学成像的造影剂。 造影剂可用于诊断子宫内膜异位症，用于随访疾病发展进展，以及随访子宫内膜异位症的治疗。 此外，本发明提供了用于子宫内膜异位症的光学成像的方法。 造影剂对与子宫内膜异位症相关的异常表达的靶标具有亲和力。 通过异常表达意味着靶标过表达或下调。 与正常组织相比，含有下调靶的子宫内膜异位组织可以通过少量结合的造影剂来鉴定。 在这种情况下，造影剂的量应小于正常组织的50％，优选小于10％。

    Optical Imaging Contrast Agents
    10.
    发明申请
    Optical Imaging Contrast Agents 审中-公开
    光学成像对比剂

    公开(公告)号：US20070258904A1

    公开(公告)日：2007-11-08

    申请号：US10582679

    申请日：2004-12-17

    申请人： Jo Klaveness ,  Edvin Johannesen ,  Helge Tolleshaug

    发明人： Jo Klaveness ,  Edvin Johannesen ,  Helge Tolleshaug

    IPC分类号： A61K49/00 ,  C12N15/00

    CPC分类号： A61K49/0032 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056

    摘要： The invention provides contrast agents for optical imaging of oesophageal cancer and Barrett's oesophagus in patients. The contrast agents may be used in diagnosis of oesophageal cancer and Barrett's oesophagus, for follow up of progress in disease development, for follow up of treatment of oesophageal cancer and Barrett's oesophagus and for surgical guidance. Further, the invention provides methods for optical imaging of oesophageal cancer and Barrett's oesophagus in patients.

    摘要翻译： 本发明提供了用于患者食管癌和Barrett食管的光学成像的造影剂。 造影剂可用于食管癌和巴雷特食管的诊断，用于跟踪疾病发展进展，跟进食管癌和巴雷特食管的治疗以及手术指导。 此外，本发明提供了食管癌和Barrett食管的光学成像方法。