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1.发明申请POLYPEPTIDES FOR BINDING TO THE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS AS WELL AS COMPOSITIONS AND METHODS INVOLVING 审中-公开用于结合高级糖化终端的受体的多肽作为组合物和涉及的方法公开(公告)号：US20120282637A1
公开(公告)日：2012-11-08
申请号：US13500400
申请日：2010-10-08
申请人： Jochen Huber , Francis Blanche , Tarik Dabdoubi , Fabienne Soubrier , Ingo Focken , Jochen Kruip , Kathrin Heermeier , Christian Lange
发明人： Jochen Huber , Francis Blanche , Tarik Dabdoubi , Fabienne Soubrier , Ingo Focken , Jochen Kruip , Kathrin Heermeier , Christian Lange
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , C12N1/21 , G01N21/64 , C12N5/10 , C12N1/15 , C12N5/16 , G01N33/566 , G01N33/577 , C07K16/46 , C12N1/19
CPC分类号： C07K16/28 , A61K38/00 , C07K2317/92
摘要： The present invention relates to a polypeptide or polypeptide complex comprising at least the two amino acid sequences arranged to allow for specific binding to the “receptor for advanced glycation endproducts” (RAGE), one or more nucleic acid(s) coding for the polypeptide or polypeptide complex, a cell producing an antibody against RAGE, a pharmaceutical composition comprising at least one polypeptide or nucleic as defined above, optionally for treating a RAGE-related disease or disorder and a method of diagnosing a RAGE-related disease or disorder.
摘要翻译： 本发明涉及包含至少两个氨基酸序列的多肽或多肽复合物，所述两个氨基酸序列被排列成允许特异性结合受体以用于晚期糖基化终产物（RAGE），编码多肽或多肽复合体的一个或多个核酸 ，产生针对RAGE的抗体的细胞，包含至少一种如上定义的多肽或核酸的药物组合物，任选地用于治疗RAGE相关疾病或病症，以及诊断RAGE相关疾病或病症的方法。
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2.发明授权Antagonist antibodies and their fab fragments against GPVI and uses thereof 有权拮抗剂抗体及其针对GPVI的Fab片段及其用途公开(公告)号：US08852593B2
公开(公告)日：2014-10-07
申请号：US13515650
申请日：2010-12-17
申请人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
发明人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K1/1075 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.
摘要翻译： 本发明公开了特异性结合人血小板膜蛋白Glycoprotein VI（GPVI）及其单价片段或衍生物的新型抗体。 本发明的抗体是来自杂交瘤克隆390的抗体及其能诱导GPVI消耗表型的片段抗体。 这些抗体和Fab片段能够阻断胶原结合，从而阻止胶原的血小板活化。 本发明还涉及用于产生所公开的抗体和Fab片段的杂交瘤克隆和表达质粒。 本发明还涉及一价抗体片段用于制备用于治疗血栓形成和其它血管疾病的研究，诊断和免疫治疗剂的用途。 本发明还涉及在C-末端具有分子的Fab，以及使用这种修饰的Fab预防用抗体识别Fab的方法。 本发明涉及当使用抗GP VI Fab时预防血小板活化的方法。
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3.发明申请NOVEL ANTAGONIST ANTIBODIES AND THEIR FAB FRAGMENTS AGAINST GPVI AND USES THEREOF 有权新型拮抗剂抗体及其抗GPVI及其用途的FAB片段公开(公告)号：US20120244152A1
公开(公告)日：2012-09-27
申请号：US13515650
申请日：2010-12-17
申请人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
发明人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
CPC分类号： C07K16/28 , A61K2039/505 , C07K1/1075 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion pheno-type. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.
摘要翻译： 本发明公开了特异性结合人血小板膜蛋白Glycoprotein VI（GPVI）及其一价片段或衍生物的新型抗体。 本发明的抗体是来自杂交瘤克隆390的抗体及其能诱导GPVI消耗物质型的片段抗体。 这些抗体和Fab片段能够阻断胶原结合，从而阻止胶原的血小板活化。 本发明还涉及用于产生所公开的抗体和Fab片段的杂交瘤克隆和表达质粒。 本发明还涉及一价抗体片段用于制备用于治疗血栓形成和其它血管疾病的研究，诊断和免疫治疗剂的用途。 本发明还涉及在C-末端具有分子的Fab，以及使用这种修饰的Fab预防用抗体识别Fab的方法。 本发明涉及当使用抗GP VI Fab时预防血小板活化的方法。
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公开(公告)号：US20110150903A1
公开(公告)日：2011-06-23
申请号：US13002845
申请日：2009-07-07
申请人： Nicolas Baurin , Pierre-Francois Berne , Francis Blanche , Francoise Bono , Beatrice Cameron , Tarik Dabdoubi , Corentin Herbert , Vincent Mikol , Elisabeth Remy
发明人： Nicolas Baurin , Pierre-Francois Berne , Francis Blanche , Francoise Bono , Beatrice Cameron , Tarik Dabdoubi , Corentin Herbert , Vincent Mikol , Elisabeth Remy
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/303 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to FGF-R4 receptor-specific antagonist molecules enabling the inhibition of the activity of said receptor. Said antagonists are, particularly, FGF-R4-specific antibodies enabling the inhibition of the activity of said receptor. The present invention also relates to the therapeutic use of said antibodies, particularly in the field of angiogenesis and in the treatment of certain types of cancer.
摘要翻译： 本发明涉及能够抑制所述受体的活性的FGF-R4受体特异性拮抗剂分子。 所述拮抗剂尤其是能够抑制所述受体活性的FGF-R4特异性抗体。 本发明还涉及所述抗体的治疗用途，特别是在血管生成领域和治疗某些类型的癌症中。
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公开(公告)号：US09493529B2
公开(公告)日：2016-11-15
申请号：US13641012
申请日：2011-04-08
申请人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
发明人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
IPC分类号： C07K14/475
CPC分类号： C07K14/475
摘要： The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also relates to a composition including such a recombinant protein. Another aspect of the invention involves using a Robo1-Fc molecule as a diagnostic tool for detecting the overexpression of a molecule belonging to the Slit family in a patient.
摘要翻译： 本发明涉及Robo1-Fc重组蛋白及其用于治疗其中Slit蛋白被过度表达的疾病，特别是癌症的用途。 本发明还涉及包含这种重组蛋白的组合物。 本发明的另一方面涉及使用Robo1-Fc分子作为用于检测患者中属于Slit家族的分子的过表达的诊断工具。
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公开(公告)号：US20130108641A1
公开(公告)日：2013-05-02
申请号：US13611789
申请日：2012-09-12
申请人： Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
发明人： Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
IPC分类号： C07K16/28 , A61K31/439 , A61K31/56 , A61K38/13 , A61K39/395 , A61K31/519
CPC分类号： C07K16/2866 , A61K31/439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention provides antibodies that specifically bind to human GITR (hGITR) with high affinity and antagonize the binding of hGITRL to hGITR. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-GITR antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to detect hGITR or to modulate hGITR activity, either in vitro or in vivo, are also provided by the invention.
摘要翻译： 本发明提供以高亲和力特异性结合人GITR（hGITR）的抗体，并拮抗hGITRL与hGITR的结合。 本发明还提供药物组合物，以及编码抗GITR抗体的核酸，重组表达载体和用于制备此类抗体的宿主细胞或其片段。 本发明还提供了使用本发明的抗体来检测hGITR或调节体外或体内的hGITR活性的方法。
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公开(公告)号：US20130039912A1
公开(公告)日：2013-02-14
申请号：US13641012
申请日：2011-04-08
申请人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
发明人： Francis Blanche , Beatrice Cameron , Tarik Dabdoubi , Frederique Dol-Gleizes , Pierre Fons , Catherine Prades , Jean-Pascal Herault
IPC分类号： A61K39/395 , C07H21/04 , A61P35/00 , C07K19/00
CPC分类号： C07K14/475
摘要： The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also relates to a composition including such a recombinant Another aspect of the invention involves using a Robo1-Fc molecule as a diagnostic tool for detecting the overexpression of a molecule belonging to the Slit family in a patient.
摘要翻译： 本发明涉及Robo1-Fc重组蛋白及其用于治疗其中Slit蛋白被过度表达的疾病，特别是癌症的用途。 本发明还涉及包含这种重组的组合物本发明的另一方面涉及使用Robo1-Fc分子作为用于检测患者中属于Slit家族的分子的过表达的诊断工具。
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8.发明授权Peptide or peptide complex binding to ALPHA2 integrin and methods and uses involving the same 有权肽或肽复合物与ALPHA2整联蛋白结合，涉及相同的方法和用途公开(公告)号：US09234039B2
公开(公告)日：2016-01-12
申请号：US13819620
申请日：2011-08-30
申请人： Carsten Corvey , Horst Blum , Béatrice Cameron , Tarik Dabdoubi , Stephanie Decary , Nicolas Baurin , David Papin , Christian Lange
发明人： Carsten Corvey , Horst Blum , Béatrice Cameron , Tarik Dabdoubi , Stephanie Decary , Nicolas Baurin , David Papin , Christian Lange
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , G01N33/68
CPC分类号： C07K16/2842 , C07K16/2839 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6857 , G01N33/6872 , G01N2333/70546 , G01N2333/7055
摘要： The present invention relates to a peptide or peptide complex binding to α2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s) for use as a medicament, a method for detecting α2 integrin and a screening method.
摘要翻译： 本发明涉及与α2整联蛋白结合的肽或肽复合物，与编码肽或肽复合物的一种或多种核酸，产生肽或肽复合物的重组细胞，产生肽或肽的方法 复合物，包含肽或肽复合物或用作药物的核酸的药物组合物，检测α2整联蛋白的方法和筛选方法。
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9.发明申请PEPTIDE OR PEPTIDE COMPLEX BINDING TO 2 INTEGRIN AND METHODS AND USES INVOLVING THE SAME 有权肽或肽复合物结合至2个整合及其涉及的方法和用途公开(公告)号：US20130156786A1
公开(公告)日：2013-06-20
申请号：US13819620
申请日：2011-08-30
申请人： Carsten Corvey , Horst Blum , Béatrice Cameron , Tarik Dabdoubi , Stephanie Decary , Nicolas Baurin , David Papin , Christian Lange
发明人： Carsten Corvey , Horst Blum , Béatrice Cameron , Tarik Dabdoubi , Stephanie Decary , Nicolas Baurin , David Papin , Christian Lange
IPC分类号： C07K16/28
CPC分类号： C07K16/2842 , C07K16/2839 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6857 , G01N33/6872 , G01N2333/70546 , G01N2333/7055
摘要： The present invention relates to a peptide or peptide complex binding to α2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s) for use as a medicament, a method for detecting α2 integrin and a screening method.
摘要翻译： 本发明涉及与α2整联蛋白结合的肽或肽复合物，一种或多种编码肽或肽复合物的核酸，产生肽或肽复合物的重组细胞，产生肽或肽的方法 复合物，包含肽或肽复合物或用作药物的核酸的药物组合物，检测α2整联蛋白的方法和筛选方法。
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