公开(公告)号：US06828649B2

公开(公告)日：2004-12-07

申请号：US10140616

申请日：2002-05-07

申请人： John C. Desko ,  Thomas J. Krutsick ,  Chung-Ming Hsieh ,  Brian E. Thompson ,  Bailey Jones ,  Steve Wallace

发明人： John C. Desko ,  Thomas J. Krutsick ,  Chung-Ming Hsieh ,  Brian E. Thompson ,  Bailey Jones ,  Steve Wallace

IPC分类号： H01L2900

CPC分类号： H01L21/763 ,  H01L21/743 ,  H01L23/522 ,  H01L2924/0002 ,  H01L2924/00

摘要： The present invention provides a semiconductor device, a method of manufacture therefor, and an integrated circuit including the same. In one advantageous embodiment, the semiconductor device includes a doped layer located over a semiconductor substrate, and an isolation trench located in the doped layer and having a dielectric layer located on a sidewall thereof. The semiconductor device may further include a conductive material located within the isolation trench and an interconnect that electrically connects the conductive material and the doped layer.

摘要翻译： 本发明提供一种半导体器件及其制造方法以及包括该半导体器件的集成电路。 在一个有利的实施例中，半导体器件包括位于半导体衬底上的掺杂层和位于掺杂层中并且位于其侧壁上的介电层的隔离沟槽。 半导体器件还可以包括位于隔离沟槽内的导电材料和电连接导电材料和掺杂层的互连。

公开(公告)号：US06737311B2

公开(公告)日：2004-05-18

申请号：US09964041

申请日：2001-09-26

申请人： John Desko ,  Chung-Ming Hsieh ,  Bailey Jones ,  Thomas J. Krutsick ,  Brian Thompson ,  Steve Wallace

发明人： John Desko ,  Chung-Ming Hsieh ,  Bailey Jones ,  Thomas J. Krutsick ,  Brian Thompson ,  Steve Wallace

IPC分类号： H01L2972

CPC分类号： H01L27/0921 ,  H01L21/823878 ,  H01L21/823892

摘要： The present invention provides a semiconductor device, a method of manufacture therefor, and an integrated circuit including the semiconductor device. The semiconductor device may include a well doped with a P-type dopant located over a semiconductor substrate. The semiconductor device may further include a buried layer including the P-type dopant located between the well and the semiconductor substrate, and a gate located over the well.

摘要翻译： 本发明提供一种半导体器件及其制造方法以及包括半导体器件的集成电路。 半导体器件可以包括掺杂有位于半导体衬底上的P型掺杂剂的阱。 半导体器件还可以包括掩埋层，其包括位于阱和半导体衬底之间的P型掺杂剂，以及位于阱上方的栅极。

公开(公告)号：US06690037B1

公开(公告)日：2004-02-10

申请号：US09653616

申请日：2000-08-31

申请人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

发明人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

IPC分类号： H01L2974

CPC分类号： H01L29/402 ,  H01L29/872

摘要： A Schottky diode is fabricated by a sequence of fabrication by a sequence of fabrication steps. An active region of a semiconductor substrate is defined in which a Schottky diode is fabricated. At least first and second layers of insulating material are applied over the active area. A first layer of insulating material, having a first etching rate, is applied over the active area. A second layer of insulating material having a second, greater, etch rate is applied over the first layer of insulating material to a thickness that is about twice the thickness of the first layer of insulating material. The insulating material is patterned and a window is etched through the layers of insulating material to the semiconductor substrate. Metal is applied and unwanted metal is etched away leaving metal in the window forming a Schottky contact therein. One or more barrier layers may be employed.

摘要翻译： 通过一系列制造步骤制造肖特基二极管。 定义半导体衬底的有源区，其中制造肖特基二极管。 至少第一和第二层绝缘材料施加在有效区域上。 在有源区域上施加具有第一蚀刻速率的第一绝缘材料层。 具有第二，更大蚀刻速率的第二层绝缘材料施加在绝缘材料的第一层上，其厚度约为第一绝缘材料层厚度的两倍。 对绝缘材料进行图案化，并且通过绝缘材料层蚀刻窗口到半导体衬底。 金属被施加并且不需要的金属被蚀刻掉，留下窗口中的金属在其中形成肖特基接触。 可以采用一个或多个阻挡层。

公开(公告)号：US06790753B2

公开(公告)日：2004-09-14

申请号：US10696136

申请日：2003-10-29

申请人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

发明人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

IPC分类号： H01L2128

CPC分类号： H01L29/402 ,  H01L29/872

摘要： A Schottky diode is fabricated by a sequence of fabrication by a sequence of fabrication steps. An active region of a semiconductor substrate is defined in which a Schottky diode is fabricated. At least first and second layers of insulating material are applied over the active area. A first layer of insulating material, having a first etching rate, is applied over the active area. A second layer of insulating material having a second, greater, etch rate is applied over the first layer of insulating material to a thickness that is about twice the thickness of the first layer of insulating material. The insulating material is patterned and a window is etched through the layers of insulating material to the semiconductor substrate. Metal is applied and unwanted metal is etched away leaving metal in the window forming a Schottky contact therein. One or more barrier layers may be employed.

公开(公告)号：US08962803B2

公开(公告)日：2015-02-24

申请号：US12389927

申请日：2009-02-20

申请人： Bernhard K. Mueller ,  Martin Schmidt ,  Eve Barlow ,  Mary Leddy ,  Chung-Ming Hsieh ,  Philip Bardwell

发明人： Bernhard K. Mueller ,  Martin Schmidt ,  Eve Barlow ,  Mary Leddy ,  Chung-Ming Hsieh ,  Philip Bardwell

IPC分类号： C07K16/00

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/466

摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

摘要翻译： 本发明涉及结合并中和RGM A蛋白的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制RGM A与其受体和/或共受体结合的能力。 本发明的这些抗体或其部分可用于检测RGM A和抑制RGM A活性，例如在患有包括但不限于多发性硬化，哺乳动物脑外伤，脊髓损伤，中风，神经变性疾病 和精神分裂症。

公开(公告)号：US20140356909A1

公开(公告)日：2014-12-04

申请号：US14263724

申请日：2014-04-28

申请人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

发明人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

IPC分类号： C07K16/46 ,  C07K16/24

CPC分类号： C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

公开(公告)号：US08779101B2

公开(公告)日：2014-07-15

申请号：US13959648

申请日：2013-08-05

申请人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

发明人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

IPC分类号： A61K39/00

CPC分类号： C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

摘要翻译： 与用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。

公开(公告)号：US20130171096A1

公开(公告)日：2013-07-04

申请号：US13659647

申请日：2012-10-24

申请人： Chung-Ming Hsieh ,  Alexander Ivanov ,  Wendy Waegell

发明人： Chung-Ming Hsieh ,  Alexander Ivanov ,  Wendy Waegell

IPC分类号： C07K16/18 ,  A61K31/56 ,  A61K31/353 ,  A61K38/17 ,  A61K38/21 ,  A61K38/20 ,  A61K31/519 ,  A61K31/439 ,  A61K38/13 ,  A61K38/18 ,  A61K31/4439 ,  A61K38/19 ,  A61K39/395 ,  A61K31/44

CPC分类号： C07K16/468 ,  A61K31/353 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/519 ,  A61K31/56 ,  A61K38/13 ,  A61K38/1793 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/191 ,  A61K38/2026 ,  A61K38/2066 ,  A61K38/2073 ,  A61K38/217 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

摘要： Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.

公开(公告)号：US20130164256A1

公开(公告)日：2013-06-27

申请号：US13659658

申请日：2012-10-24

申请人： Chung-Ming Hsieh ,  Tariq Ghayur ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Jennifer Perez ,  Suju Zhong ,  Carrie Goodreau ,  Anca Clabbers

发明人： Chung-Ming Hsieh ,  Tariq Ghayur ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Jennifer Perez ,  Suju Zhong ,  Carrie Goodreau ,  Anca Clabbers

IPC分类号： C07K16/24 ,  A61K45/06 ,  A61K47/48 ,  A61K39/395 ,  C07K16/46 ,  G01N33/68

CPC分类号： C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863

摘要： Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

摘要翻译： 公开了结合肿瘤坏死因子-α（TNF-α），例如人TNF-α和相关的基于抗体的组合物和分子的分离的结合蛋白，例如抗体或其抗原结合部分。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。

公开(公告)号：US08323651B2

公开(公告)日：2012-12-04

申请号：US12437715

申请日：2009-05-08

申请人： Jijie Gu ,  Chung-Ming Hsieh ,  Zhen Wu ,  Enrico L. DiGiammarino ,  Feng Luo ,  Gerard B. Fox ,  John E. Harlan ,  Martin Schmidt ,  Ralf Loebbert ,  Reinhold Mueller ,  Ulrich Ebert ,  Volker Nimmrich

发明人： Jijie Gu ,  Chung-Ming Hsieh ,  Zhen Wu ,  Enrico L. DiGiammarino ,  Feng Luo ,  Gerard B. Fox ,  John E. Harlan ,  Martin Schmidt ,  Ralf Loebbert ,  Reinhold Mueller ,  Ulrich Ebert ,  Volker Nimmrich

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P25/28 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/464 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C12P21/005 ,  Y02A50/466

摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid β and advanced glycation-end-products.

摘要翻译： 本申请涉及分离的蛋白质，特别是单克隆抗体，特别是结合RAGE蛋白质的CDR-移植的人源化抗体。 具体地说，这些抗体具有抑制RAGE与其各种配体结合的能力。 本申请中描述的抗体或其部分可用于治疗由RAGE的病理生理学配体表征或诱导的疾病或病症，例如错误折叠的蛋白质如淀粉样蛋白和bgr; 和晚期糖基化终产物。