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    Sulfonamide containing compounds for treatment of inflammatory disorders
    3.
    发明授权
    Sulfonamide containing compounds for treatment of inflammatory disorders 失效
    含磺酰胺的化合物用于治疗炎症性疾病

    公开(公告)号：US07897776B2

    公开(公告)日：2011-03-01

    申请号：US12148966

    申请日：2008-04-23

    申请人： M. David Weingarten ,  Charles Q. Meng ,  James A. Sikorski ,  Raymond Ng ,  Wei Zhang

    发明人： M. David Weingarten ,  Charles Q. Meng ,  James A. Sikorski ,  Raymond Ng ,  Wei Zhang

    IPC分类号： C07D421/00 ,  C07D207/00

    CPC分类号： C07D401/12 ,  C07D207/48 ,  C07D405/12 ,  C07D417/12

    摘要： Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of an inflammatory condition, in particular asthma. The compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof: wherein: X and Y are independently selected from —CH2— or —CH2—CH2—; Z is selected from S(O)m or Se(O)m and m is 0, 1 or 2; R1 is optionally substituted heteroaryl or heterocyclic; R2 is selected from the group consisting of hydrogen, C1-C6 straight alkyl, and C1-C6 branched alkyl, wherein all may be optionally substituted; and R3 and R4 are alkyl.

    摘要翻译： 提供化合物，药物组合物和治疗或预防炎性病症，特别是哮喘的方法。 所述化合物具有通式I或其药学上可接受的盐，酯，前药或衍生物：其中：X和Y独立地选自-CH 2 - 或-CH 2 -CH 2 - ; Z选自S（O）m或Se（O）m，m为0,1或2; R1是任选取代的杂芳基或杂环; R 2选自氢，C 1 -C 6直链烷基和C 1 -C 6支链烷基，其中全部可以被任选取代; R3和R4是烷基。

    Process of preparing esters and ethers of probucol and derivatives thereof
    10.
    发明授权
    Process of preparing esters and ethers of probucol and derivatives thereof 失效
    丙磺舒及其衍生物的酯和醚的制备方法

    公开(公告)号：US07273948B2

    公开(公告)日：2007-09-25

    申请号：US10757664

    申请日：2004-01-13

    申请人： M. David Weingarten ,  James A. Sikorski

    发明人： M. David Weingarten ,  James A. Sikorski

    IPC分类号： C07C69/34 ,  C07C67/02 ,  C07C321/00

    CPC分类号： C07C319/20 ,  C07C323/20

    摘要： A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.

    摘要翻译： 普罗布考或普罗布考衍生物可以通过游离含羟基的普罗布考或其衍生物的反应而有效地转化成普罗布考的单酯或单醚（通过这种方法将普罗布考化合物与至少一个不同于母体的取代基的化合物反应 普罗布考分子，但其保持两个游离羟基）与格氏试剂或锂试剂反应产生溴丙醇或普罗布考的锂盐或丙磺舒酚衍生物。 然后将普罗布考复合阴离子阴离子与酯或醚形成化合物反应。