公开(公告)号：US20200181571A1

公开(公告)日：2020-06-11

申请号：US16462346

申请日：2017-12-13

Applicant: L'OREAL

Inventor： Theebah SELLATHURAI ,  Khalid BAKKAR

IPC: C12N5/071 ,  C12N5/0775

Abstract: The invention relates to the use of germ cells for obtaining a micro hair follicle and to the use thereof for evaluating the effect of cosmetic, pharmaceutical or dermatological products and also for the prophylactic or therapeutic treatment of a state of reduced pilosity.

公开(公告)号：US20200255801A1

公开(公告)日：2020-08-13

申请号：US16760109

申请日：2018-10-30

Applicant: L'OREAL

Inventor： Khalid BAKKAR ,  Theebah SELLATHURAI

IPC: C12N5/071 ,  G01N33/50 ,  A61K35/36

Abstract: The invention relates to a process for the in vitro preparation of a dermal papilla equivalent from fibroblasts derived from the dermal papilla and/or from the connective tissue sheath; to a process for the in vitro preparation of a hair follicle equivalent by culturing proliferative epithelial cells on said dermal papillae thus obtained; to the in vitro dermal papilla and hair follicle equivalents produced by means of the abovementioned processes, and to the uses thereof for treating alopecia and for evaluating the effect of cosmetic, pharmaceutical or dermatological products.

公开(公告)号：US20230265511A1

公开(公告)日：2023-08-24

申请号：US18002270

申请日：2021-06-30

Applicant: L'OREAL

Inventor： Yann MAHE ,  Khalid BAKKAR ,  Elias BOU SAMRA

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/158

Abstract: The present invention relates to a method for the in vitro prognosis and/or diagnosis of a common alopecic state of the scalp in a subject, comprising at least one step a) of measuring the expression level, in a biological sample from an area suspected of being an alopecic area or of becoming an alopecic area in said subject, of at least one gene involved in the intercellular junctions of the scalp and/or of the hair follicle chosen from CDH1, ACTB, ACTBL2, TUBB, TUBB2A, GSN, MYO3B, MYO5B, MYO6, DSG2, DSG3, DSG4, DSC2, GJB2, GJA1, GJB6, GJA3, TJP2, CLDN8, CLDN10, CLDN19, and optionally of at least one gene chosen from CTNNB1 and CTNND2, wherein said common alopecic state is chosen from androgenetic alopecia, traction alopecia, female pattern hair loss, cicatricial alopecia, telogen effluvium, stress-related alopecia, seasonal alopecia, age-related alopecia and micro-inflammatory alopecia.
The invention also relates to an in vitro method for evaluating the efficacy of a treatment of a common alopecic state, to a cosmetic treatment method, to the use of a modulator of said abovementioned gene(s), and also to a method for identifying a compound which allows the prevention and/or treatment of a common alopecic state.

公开(公告)号：US20180258390A1

公开(公告)日：2018-09-13

申请号：US15761158

申请日：2016-09-28

Applicant: L'OREAL

Inventor： Khalid BAKKAR ,  Christine COLLIN-DJANGONE

IPC: C12N5/071 ,  A61K35/36 ,  G01N33/50

CPC classification number: C12N5/0628 ,  A61K35/36 ,  C12N5/0627 ,  C12N5/0629 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2501/727 ,  C12N2513/00 ,  G01N33/5044

Abstract: The invention relates to the use of matrix cells for obtaining a micro hair follicle and to the use thereof for evaluating the effect of cosmetic, pharmaceutical or dermatological products and also for the prophylactic or therapeutic treatment of a state of reduced pilosity.