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公开(公告)号：US12061189B2
公开(公告)日：2024-08-13
申请号：US16624087
申请日：2018-06-21
Applicant: Laboratoires Expanscience
Inventor： Gaelle Bellemere , Stephanie Bredif , Gaetan Boyer , Caroline Baudouin
CPC classification number: G01N33/5088 , C12N5/0698 , C12N2503/06
Abstract: The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.
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公开(公告)号：US11026880B2
公开(公告)日：2021-06-08
申请号：US14652449
申请日：2013-12-18
Applicant: Laboratoires Expanscience
Inventor： Philippe Msika , Sophie Leclere-Bienfait , Sebastien Debrock , Stephanie Bredif , Sebastien Garnier
IPC: A61K8/97 , A61Q19/08 , A61K36/185 , A61Q19/06 , A61Q17/00 , A61K8/60 , A61K8/64 , A61K45/06 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q7/00
Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.
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公开(公告)号：US10688142B2
公开(公告)日：2020-06-23
申请号：US16243491
申请日：2019-01-09
Applicant: Laboratoires Expanscience
Inventor： Sophie Leclere-Bienfait , Stephanie Bredif , Sebastien Debrock , Sebastien Garnier
IPC: A61K36/185 , A61Q19/00 , A61Q19/08 , A61K8/97 , A23L33/105 , A61Q19/06 , A61K9/00 , A61K9/06 , A61K9/107 , A23D9/007 , C11B3/00 , A61P17/02 , A61K8/31 , A61K8/36 , A61K8/63 , A61K8/67 , A61K8/92 , A61K31/01 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/355 , A61K31/56 , A61Q19/04 , C11B3/02 , C11B3/12
Abstract: A method to treat skin or mucosa cells or disorders related to dermal tissue by topically administering to a person in a need thereof a lipid extract from Passiflora seeds selected from Passiflora incarnate seeds, Passiflora edulis seeds, and a combination thereof, wherein said lipid extract is oil of Passiflora seeds concentrated in its unsaponifiable fraction containing 3 to 100 weight % of unsaponifiables relative to the total weight of the extract.
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公开(公告)号：US10196607B2
公开(公告)日：2019-02-05
申请号：US15110826
申请日：2015-01-12
Applicant: Laboratoires Expanscience
Inventor： Stephanie Bredif , Caroline Baudouin , Philippe Msika , Marisa Meloni
Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin.
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公开(公告)号：US20160245795A1
公开(公告)日：2016-08-25
申请号：US15023882
申请日：2014-09-24
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Stephanie Bredif , Philippe MSIKA
CPC classification number: G01N33/5023 , G01N33/5044 , G01N33/6881 , G01N2333/4721 , G01N2333/5421 , G01N2333/545 , G01N2333/96486
Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.
Abstract translation: 本发明涉及用于测试制剂或活性成分以防止紫外线对儿童皮肤，特别是三岁以下儿童的有害影响的体外方法。 本发明人已经开发了使用特别能够再现这种年龄的儿童的皮肤特征的皮肤模型来评价制剂在体外预防紫外线对三岁以下儿童皮肤的有害影响的体外功效的方法。
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Patent Agency Ranking
6.发明申请EXTRACT OF PASSIONFLOWER SEEDS AND COSMETIC, PHARMACEUTICAL, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME 审中-公开SION草种子和化妆品，药物，皮肤和营养组合物的提取物公开(公告)号：US20160074312A1
公开(公告)日：2016-03-17
申请号：US14652449
申请日：2013-12-18
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Sophie Leclere-Bienfait , Sebastien Debrock , Stephanie Bredif , Sebastien Garnier
IPC: A61K8/97 , A61K8/60 , A61Q19/02 , A61Q19/08 , A61Q5/12 , A61Q19/00 , A61K36/185 , A61K45/06 , A61Q5/02 , A61K8/64 , A61Q17/04
CPC classification number: A61K8/97 , A61K8/60 , A61K8/645 , A61K36/185 , A61K45/06 , A61K2236/15 , A61K2236/19 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q17/00 , A61Q17/04 , A61Q19/005 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08
Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.
Abstract translation: 本发明涉及包含西番莲花提取物，优选西番莲花种子的组合物。 该组合物有利地是化妆品，药物，皮肤病学或营养品。 本发明的主题也是提取西番莲子提取物和优选西番莲种子的方法，以及可以通过所述方法获得的提取物。 本发明还涉及用于预防或治疗皮肤，粘膜或皮肤附件的疾病或病理状况的用于预防或治疗血管疾病的组合物或这种提取物，用于 用于抵抗氧化应激，或用于预防或治疗脂肪组织修饰。 最后，本发明涉及一种美容护理方法，用于皮肤，皮肤附属物或粘膜，以改善其状况或其外观，包括施用这样的组合物或这种提取物。
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公开(公告)号：US11892447B2
公开(公告)日：2024-02-06
申请号：US16062488
申请日：2016-12-16
Applicant: Laboratoires Expanscience
Inventor： Stephanie Bredif , Caroline Baudouin
IPC: G01N33/50 , G01N33/68 , C12N5/071 , C12Q1/6883
CPC classification number: G01N33/5088 , C12N5/0698 , C12Q1/6883 , G01N33/6881 , C12Q2600/148 , C12Q2600/158
Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
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公开(公告)号：US11604184B2
公开(公告)日：2023-03-14
申请号：US16311378
申请日：2017-06-23
Applicant: Laboratoires Expanscience
Inventor： Caroline Baudouin , Stephanie Bredif
IPC: C12Q1/68 , G01N33/50 , C12Q1/6883 , C12N5/00 , C12N5/071
Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
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公开(公告)号：US10175230B2
公开(公告)日：2019-01-08
申请号：US14785212
申请日：2014-04-22
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin , Stephanie Bredif
Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.
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公开(公告)号：US09952201B2
公开(公告)日：2018-04-24
申请号：US15023882
申请日：2014-09-24
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Stephanie Bredif , Philippe Msika
CPC classification number: G01N33/5023 , G01N33/5044 , G01N33/6881 , G01N2333/4721 , G01N2333/5421 , G01N2333/545 , G01N2333/96486
Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.
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