公开(公告)号：US20190218496A1

公开(公告)日：2019-07-18

申请号：US16238591

申请日：2019-01-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Christopher Brau ,  Nephi JONES ,  Mark SMITH

IPC: C12M1/42 ,  C12M1/00 ,  C12M1/06 ,  C12N5/071

CPC classification number: B01F7/00391 ,  B01F3/04531 ,  B01F7/0005 ,  B01F7/00725 ,  B01F7/24 ,  B01F15/00538 ,  B01F15/00707 ,  B01F15/0085 ,  B01F2003/04673 ,  B01F2015/0011 ,  B01F2015/00603 ,  B01F2215/0073 ,  C12M23/58 ,  C12M27/02 ,  C12M27/06 ,  C12M35/04 ,  C12N5/0602 ,  C12N2527/00

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

公开(公告)号：US20230091993A1

公开(公告)日：2023-03-23

申请号：US18051126

申请日：2022-10-31

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Christopher Brau ,  Nephi Jones ,  Mark Smith

IPC: C12M1/42 ,  C12M1/00 ,  C12N5/071 ,  C12M1/06 ,  B01F23/233 ,  B01F27/054 ,  B01F27/92 ,  B01F27/114 ,  B01F27/213 ,  B01F35/43 ,  B01F35/513 ,  B01F35/32 ,  B01F35/41 ,  C12M1/36

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

公开(公告)号：US11584910B2

公开(公告)日：2023-02-21

申请号：US16238591

申请日：2019-01-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Christopher Brau ,  Nephi Jones ,  Mark Smith

IPC: B01F23/00 ,  B01F27/00 ,  C12M1/42 ,  C12M1/00 ,  C12N5/071 ,  C12M1/06 ,  B01F23/233 ,  B01F27/054 ,  B01F27/92 ,  B01F27/114 ,  B01F27/213 ,  B01F35/43 ,  B01F35/513 ,  B01F35/32 ,  B01F35/41 ,  C12M1/36 ,  B01F27/90 ,  B01F35/30 ,  B01F101/44

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

公开(公告)号：US12227732B2

公开(公告)日：2025-02-18

申请号：US18051126

申请日：2022-10-31

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Christopher Brau ,  Nephi Jones ,  Mark Smith

IPC: B01F23/00 ,  B01F23/233 ,  B01F27/054 ,  B01F27/114 ,  B01F27/213 ,  B01F27/92 ,  B01F35/32 ,  B01F35/41 ,  B01F35/43 ,  B01F35/513 ,  C12M1/00 ,  C12M1/06 ,  C12M1/36 ,  C12M1/42 ,  C12N5/071 ,  B01F27/90 ,  B01F35/30 ,  B01F101/44

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

公开(公告)号：US11529598B2

公开(公告)日：2022-12-20

申请号：US16424629

申请日：2019-05-29

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGIES HOLDINGS PTE LIMITED

Inventor： Joshua Mead ,  Scott Rickes ,  Sean Zimmerman ,  Alessandra Barbosa ,  Mio Ling ,  Woon Liang Soh ,  Kevin Mullen ,  Christopher Brau ,  Jordan Cobia ,  Harmon Jr Cosme Sicat ,  Kok Shyong Chong ,  Han Wei ,  Wei Fuh Teo ,  Syed Muhammad Baber Ali

IPC: C12M1/02 ,  B01F33/84 ,  C12M1/00 ,  C12M1/06 ,  C12M1/36 ,  B01F35/513 ,  G08B21/18 ,  B01F101/44

Abstract: The present set of embodiments relate to a system, method, and apparatus controlling a cell culture media mixing system. The control system includes an integrated control unit capable of controlling a broad ranges of peripheral devices commonly used in bioproduction through a graphical user interface displayed on a touch sensitive screen. The bioproduction system is designed to be highly customizable through process modification and recipe creation by user with little or no knowledge of programming and is capable of controlling a wide variety of devices using a single unit. The bioproduction system allows for auto-detection, auto-calibration, and automatic of device related processes into a bioproduction workflow.

公开(公告)号：US20250154445A1

公开(公告)日：2025-05-15

申请号：US19019877

申请日：2025-01-14

Applicant: Life Technologies Corporation

Inventor： Christopher Brau ,  Nephi Jones ,  Mark Smith

IPC: C12M1/42 ,  B01F23/233 ,  B01F27/054 ,  B01F27/114 ,  B01F27/213 ,  B01F27/90 ,  B01F27/92 ,  B01F35/30 ,  B01F35/32 ,  B01F35/41 ,  B01F35/43 ,  B01F35/513 ,  B01F101/44 ,  C12M1/00 ,  C12M1/06 ,  C12M1/36 ,  C12N5/071

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

公开(公告)号：USD1032646S1

公开(公告)日：2024-06-25

申请号：US29771136

申请日：2021-02-19

Applicant: Life Technologies Corporation ,  Life Technologies Holdings PTE Limited

Designer： Joshua Mead ,  Scott Rickes ,  Sean Zimmerman ,  Alessandra Barbosa ,  Mio Ling ,  Woon Liang Soh ,  Kevin Mullen ,  Christopher Brau ,  Jordan Cobia ,  Harmon Cosme Sicat, Jr.

Abstract: The sole FIGURE is a front view of a display screen with graphical user interface for fluid mixing apparatus showing our new design.
The broken lines showing features of the display screen with graphical user interface are included for the purpose of illustrating portions of the article and form no part of the claimed design.

公开(公告)号：US20230123126A1

公开(公告)日：2023-04-20

申请号：US18053089

申请日：2022-11-07

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGIES HOLDINGS PTE LIMITED

Inventor： Joshua Mead ,  Scott Rickes ,  Sean Zimmerman ,  Alessandra Barbosa ,  Kevin Mullen ,  Christopher Brau ,  Jordan Cobia ,  Mio Ling ,  Woon Liang Soh ,  Harmon Cosme Sicat, JR. ,  Kok Shyong Chong ,  Han Wei ,  Wei Fuh Teo ,  Syed Muhammad Baber Ali

IPC: B01F33/84 ,  C12M1/00 ,  C12M1/06 ,  C12M1/36 ,  B01F35/513

Abstract: A bioproduction mixer control system includes a mixing compartment having a biological fluid and a mixing element; a sensor in communication with the mixing compartment, the sensor configured to detect an environmental condition within the mixing compartment; and an integrated control unit. The integrated control unit includes a memory for storing the environmental condition, sensor information relating to the sensor, and process workflow information; a user interface comprising a display depicting a bioproduction workspace, wherein the bioproduction workspace comprises a process workflow title and a plurality of bioprocess modules; and a central processing unit in electronic communication with the sensor, memory and user interface.

公开(公告)号：USD914727S1

公开(公告)日：2021-03-30

申请号：US29728310

申请日：2020-03-17

Applicant: Life Technologies Corporation ,  Life Technologies Holdings PTE Limited

Designer： Joshua Mead ,  Scott Rickes ,  Sean Zimmerman ,  Alessandra Barbosa ,  Mio Ling ,  Woon Liang Soh ,  Kevin Mullen ,  Christopher Brau ,  Jordan Cobia ,  Harmon Cosme Sicat, Jr.