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公开(公告)号：US06699471B2
公开(公告)日：2004-03-02
申请号：US09887757
申请日：2001-06-21
IPC分类号： C12N500
CPC分类号： A61L27/3817 , A61L27/20 , A61L27/3839 , A61L27/3852 , A61L2400/06 , C08L5/08
摘要： Disclosed is an injectable, biocompatible and biodegradable composition, comprising at least one hyaluronic acid benzyl ester or auto-cross-linked derivative, in combination with at least one mammalian cell and/or at least one pharmacologically or biologically active substance and/or micro-particles such as fibres, granules, microspheres or sponge fragments of a hyaluronic acid derivative.
摘要翻译： 公开了一种可注射的，生物相容的和可生物降解的组合物，其包含至少一种透明质酸苄酯或自交联衍生物与至少一种哺乳动物细胞和/或至少一种药理学或生物活性物质和/ 颗粒如透明质酸衍生物的纤维，颗粒，微球或海绵片。
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公开(公告)号：US06642213B1
公开(公告)日：2003-11-04
申请号：US09719200
申请日：2000-12-08
IPC分类号： A61K31715
CPC分类号： C08B37/0072 , A61L15/28 , A61L27/20 , A61L27/3804 , C08L5/08
摘要： A three-dimensional prosthesis is described in the shape of a body part comprising at least one three-dimensional matrix having an essentially fibrous or porous structure and containing a hyaluronic acid derivative, said prosthesis, contains at least two of said three-dimensional matrixes, the first of said three-dimensional matrixes incorporating or being adhered to the second and possible further matrixes, said three-dimensional matrix(es) optionally inicorporating and/or being adhered to a bidimensional perforated matrix and containing a hyaluronic acid derivative. This prosthesis is used for reconstruction of human or animal body part.
摘要翻译： 三维假体被描述为身体部位的形状，其包括至少一个具有基本纤维或多孔结构并且含有透明质酸衍生物的三维基质，所述假体包含至少两个所述三维基质， 所述三维矩阵中的第一个结合或粘附到第二和可能的另外的基质上，所述三维基质任选地合并和/或被粘附到二维穿孔基质并且含有透明质酸衍生物。 该假体用于重建人体或动物体部位。
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公开(公告)号：US07157080B2
公开(公告)日：2007-01-02
申请号：US10752464
申请日：2004-01-06
IPC分类号： C12N5/00
CPC分类号： A61L27/3817 , A61L27/20 , A61L27/3839 , A61L27/3852 , A61L2400/06 , C08L5/08
摘要： Disclosed is an injectable, biocompatible and biodegradable composition, comprising at least one hyaluronic acid benzyl ester or auto-cross-linked derivative, in combination with at least one mammalian cell and/or at least one pharmacologically or biologically active substance and/or micro-particles such as fibres, granules, microspheres or sponge fragments of a hyaluronic acid derivative.
摘要翻译： 公开了一种可注射的，生物相容的和可生物降解的组合物，其包含至少一种透明质酸苄酯或自交联衍生物与至少一种哺乳动物细胞和/或至少一种药理学或生物活性物质和/ 颗粒如透明质酸衍生物的纤维，颗粒，微球或海绵片。
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4.发明申请公开(公告)号：US20080220053A1
公开(公告)日：2008-09-11
申请号：US11792976
申请日：2005-12-12
CPC分类号： A61L24/0015 , A61L15/32 , A61L15/44 , A61L24/10 , A61L31/043 , A61L31/16 , A61L2300/414 , A61L2300/418 , A61L2400/04
摘要： A process for the preparation of polymer scaffolds containing a pharmacologically and/or biologically active protein molecule involving the following steps: neutralisation of the scaffold with a basic substance or a buffer solution; drying the scaffold; imbibition of the scaffold with a predefined quantity of a pharmacologically and/or biologically active protein molecule.
摘要翻译： 一种制备含有药理学和/或生物活性蛋白质分子的聚合物支架的方法，包括以下步骤：用碱性物质或缓冲溶液中和支架; 干燥脚手架; 用预定量的药理学和/或生物活性蛋白质分子吸收支架。
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5.发明授权Biocompatible material and prosthetic device made thereof for the replacement, repair and regeneration of meniscus 有权由其制成的生物相容性材料和假体装置用于更换，修复和再生半月板公开(公告)号：US08901202B2
公开(公告)日：2014-12-02
申请号：US11793409
申请日：2005-12-14
IPC分类号： A61F2/00 , A61L24/00 , C08B37/00 , C08G63/48 , A61F2/38 , A61F2/30 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , A61F2/28
CPC分类号： A61F2/3872 , A61F2/30756 , A61F2/30965 , A61F2002/2867 , A61F2002/30062 , A61F2002/30133 , A61F2002/30957 , A61F2002/30971 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , C08L67/04 , C08L5/08
摘要： Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
摘要翻译： 本文描述了一种生物相容性材料，其包含基于透明质酸衍生物和聚己内酯的聚合物基质，该制备该材料的方法，由该生物相容性材料和增强材料构成的假体装置，制备该假体装置的方法， 并用于部分或全部更换半月板，再生半月板纤维软骨。
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6.发明申请Biocompatible Material and Prosthetic Device Made Thereof for the Replacement, Repair and Regeneration of Meniscus 有权生物相容材料及其修补装置用于更换，修复和再生半月板公开(公告)号：US20080097605A1
公开(公告)日：2008-04-24
申请号：US11793409
申请日：2005-12-14
IPC分类号： A61F2/02
CPC分类号： A61F2/3872 , A61F2/30756 , A61F2/30965 , A61F2002/2867 , A61F2002/30062 , A61F2002/30133 , A61F2002/30957 , A61F2002/30971 , A61F2210/0004 , A61F2230/0015 , A61F2310/00365 , A61L27/26 , A61L27/34 , A61L27/48 , A61L27/56 , C08L67/04 , C08L5/08
摘要： Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
摘要翻译： 本文描述的是包含基于透明质酸衍生物和聚ε-己内酯的聚合物基质的生物相容性材料，该材料的制备方法，由该生物相容性材料和增强材料构成的假体装置，其制备方法 用于局部或全部更换半月板，再生半月板纤维软骨。
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公开(公告)号：US20130323183A1
公开(公告)日：2013-12-05
申请号：US13985219
申请日：2012-02-13
申请人： Andrea Pastorello , Devis Galesso , Fabio Bettella
发明人： Andrea Pastorello , Devis Galesso , Fabio Bettella
IPC分类号： A61K31/738 , A61K31/196 , A61K45/06 , A61K33/38 , A61K31/728
CPC分类号： A61K31/738 , A61K9/0014 , A61K9/146 , A61K31/192 , A61K31/196 , A61K31/717 , A61K31/728 , A61K31/729 , A61K33/38 , A61K45/06 , A61K2300/00
摘要： The invention discloses pharmaceutical compositions in the form of a dusting powder or dry spray, possessing a high absorbent capacity, painkilling activity and wound-healing action, which compositions consist of croscarmellose sodium, a non-steroidal anti-inflammatory drug (NSAID) and hyaluronic acid, and optionally also contain other pharmacologically active substances and/or excipients. The compositions disclosed herein are suitable for use in the treatment of skin lesions wherein the presence of exudate limits wound healing and causes pain; they are therefore particularly suitable for chronic ulcerous skin lesions of various origins and burns.
摘要翻译： 本发明公开了具有高吸收能力，止痛活性和伤口愈合作用的粉剂或干喷雾形式的药物组合物，该组合物由交联羧甲纤维素钠，非甾体抗炎药（NSAID）和透明质酸 酸，并且任选地还含有其它药理活性物质和/或赋形剂。 本文公开的组合物适用于治疗皮肤病变，其中渗出液的存在限制伤口愈合并引起疼痛; 因此它们特别适用于各种起源和灼伤的慢性溃疡性皮肤病变。
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公开(公告)号：US08992890B2
公开(公告)日：2015-03-31
申请号：US13985219
申请日：2012-02-13
申请人： Andrea Pastorello , Devis Galesso , Fabio Bettella
发明人： Andrea Pastorello , Devis Galesso , Fabio Bettella
IPC分类号： A61K31/738 , A61K31/192 , A61K31/196 , A61K31/717 , A61K31/729 , A61K33/38 , A61K45/06 , A61K9/00 , A61K9/14 , A61K31/728
CPC分类号： A61K31/738 , A61K9/0014 , A61K9/146 , A61K31/192 , A61K31/196 , A61K31/717 , A61K31/728 , A61K31/729 , A61K33/38 , A61K45/06 , A61K2300/00
摘要： The invention discloses pharmaceutical compositions in the form of a dusting powder or dry spray, possessing a high absorbent capacity, painkilling activity and wound-healing action, which compositions consist of croscarmellose sodium, a non-steroidal anti-inflammatory drug (NSAID) and hyaluronic acid, and optionally also contain other pharmacologically active substances and/or excipients. The compositions disclosed herein are suitable for use in the treatment of skin lesions wherein the presence of exudate limits wound healing and causes pain; they are therefore particularly suitable for chronic ulcerous skin lesions of various origins and burns.
摘要翻译： 本发明公开了具有高吸收能力，止痛活性和伤口愈合作用的粉剂或干喷雾形式的药物组合物，该组合物由交联羧甲纤维素钠，非甾体抗炎药（NSAID）和透明质酸 酸，并且任选地还含有其它药理活性物质和/或赋形剂。 本文公开的组合物适用于治疗皮肤病变，其中渗出液的存在限制伤口愈合并引起疼痛; 因此它们特别适用于各种起源和灼伤的慢性溃疡性皮肤病变。
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9.发明授权Composite structures containing hyaluronic acid the derivatives thereof as new bone substitutes and grafts 有权含有透明质酸的复合结构物作为新的骨代用品和移植物公开(公告)号：US07709018B2
公开(公告)日：2010-05-04
申请号：US10580659
申请日：2004-11-26
CPC分类号： A61L27/425 , A61L27/20 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3821 , A61L27/3834 , A61L27/3847 , C08L5/08
摘要： A composite material comprising: (i) hyaluronic acid and/or hyaluronic acid derivatives, (ii) demineralised bone and/or biocompatible partially or totally demineralised bone tissue matrix and/or biocompatible and bioresorbable ceramic materials. This material preferably associated with at least one layer comprising a hyaluronic acid derivative may be used in the preparation of bone substitutes or grafts for the regeneration or formation of bone tissue in surgery.
摘要翻译： 一种复合材料，其包含：（i）透明质酸和/或透明质酸衍生物，（ii）软化骨和/或生物相容的部分或全部去矿物质骨组织基质和/或生物相容性和生物可吸收的陶瓷材料。 优选与包含透明质酸衍生物的至少一层相关联的该材料可用于制备用于在手术中再生或形成骨组织的骨替代物或移植物。
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10.发明申请Composite structures containing hyaluronic acid the derivatives thereof as new bone substitutes and grafts 有权含有透明质酸的复合结构物作为新的骨代用品和移植物公开(公告)号：US20070110819A1
公开(公告)日：2007-05-17
申请号：US10580659
申请日：2004-11-26
IPC分类号： A61K35/32 , A61K31/728 , C08B37/00
CPC分类号： A61L27/425 , A61L27/20 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3821 , A61L27/3834 , A61L27/3847 , C08L5/08
摘要： A composite material comprising: (i) hyaluronic acid and/or hyaluronic acid derivatives, (ii) demineralised bone and/or biocompatible partially or totally demineralised bone tissue matrix and/or biocompatible and bioresorbable ceramic materials. This material preferably associated with at least one layer comprising a hyaluronic acid derivative may be used in the preparation of bone substitutes or grafts for the regeneration or formation of bone tissue in surgery.
摘要翻译： 一种复合材料，其包含：（i）透明质酸和/或透明质酸衍生物，（ii）软化骨和/或生物相容的部分或全部去矿物质骨组织基质和/或生物相容性和生物可吸收的陶瓷材料。 优选与包含透明质酸衍生物的至少一层相关联的该材料可用于制备用于在手术中再生或形成骨组织的骨替代物或移植物。
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