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公开(公告)号：US20090076338A1
公开(公告)日：2009-03-19
申请号：US12299303
申请日：2007-05-02
CPC分类号： G06F19/3456 , A61B5/0002 , A61B5/0028 , A61B5/073 , A61B5/4833 , A61B5/4848 , G06F19/00 , G06F19/34 , G06F19/3418 , G06F19/345 , G06F19/3475 , G06Q10/00 , G06Q50/22 , G16H50/20 , H01M8/02 , H01M2220/10 , H04B13/005 , Y10S128/903 , Y10S128/92
摘要： Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.
摘要翻译： 提供了允许根据患者定制的治疗方案治疗患者的方法，系统和组合物。 本发明的实施方案包括从患者获得剂量给药信息并使用它来定制患者的治疗方案。 本发明的实施方案还包括基于定制的治疗方案制备并转发患者物理药物剂量。
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公开(公告)号：US08956287B2
公开(公告)日：2015-02-17
申请号：US12299303
申请日：2007-05-02
IPC分类号： G06Q50/00 , A61B5/00 , A61B5/07 , H01M8/02 , G06Q10/00 , G06Q50/22 , G06F19/00 , H04B13/00 , H01M8/00
CPC分类号： G06F19/3456 , A61B5/0002 , A61B5/0028 , A61B5/073 , A61B5/4833 , A61B5/4848 , G06F19/00 , G06F19/34 , G06F19/3418 , G06F19/345 , G06F19/3475 , G06Q10/00 , G06Q50/22 , G16H50/20 , H01M8/02 , H01M2220/10 , H04B13/005 , Y10S128/903 , Y10S128/92
摘要： Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.
摘要翻译： 提供了允许根据患者定制的治疗方案治疗患者的方法，系统和组合物。 本发明的实施方案包括从患者获得剂量给药信息并使用它来定制患者的治疗方案。 本发明的实施方案还包括基于定制的治疗方案制备并转发患者物理药物剂量。
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公开(公告)号：US20080183072A1
公开(公告)日：2008-07-31
申请号：US11664340
申请日：2007-03-30
申请人： Timothy L. Robertson , George M. Savage , Todd Thompson , Mark J. Zdeblick , Olivier Colliou , Benedict J. Costello
发明人： Timothy L. Robertson , George M. Savage , Todd Thompson , Mark J. Zdeblick , Olivier Colliou , Benedict J. Costello
IPC分类号： A61B5/05
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。 使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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4.发明授权公开(公告)号：US08036743B2
公开(公告)日：2011-10-11
申请号：US11909786
申请日：2006-03-31
申请人： George M. Savage , Todd Thompson , Mark J. Zdeblick , Lawrence W. Arne , Olivier Colliou , Benedict James Costello , Fataneh A. Omidvar
发明人： George M. Savage , Todd Thompson , Mark J. Zdeblick , Lawrence W. Arne , Olivier Colliou , Benedict James Costello , Fataneh A. Omidvar
IPC分类号： A61N1/39
CPC分类号： A61N1/3627 , A61N1/08 , A61N1/36185 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/3686 , A61N1/37247
摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.
摘要翻译： 本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。 在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。 起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。 然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。 该系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极传输的起搏信号。
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公开(公告)号：US08121687B2
公开(公告)日：2012-02-21
申请号：US11718201
申请日：2005-10-31
申请人： Marc Jensen , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
发明人： Marc Jensen , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
IPC分类号： A61N1/18
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了用于评估心脏组织位置例如心脏壁的运动的方法。 在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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公开(公告)号：US20080306394A1
公开(公告)日：2008-12-11
申请号：US12063097
申请日：2006-08-09
IPC分类号： A61B5/04
CPC分类号： A61B5/04011
摘要： A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.
摘要翻译： 用于测量组织中去极化波的传导速度的方法使用位于组织内的第一卫星，并且第二卫星位于组织内距离第一卫星一定距离，例如通过使用去极化波的时间 报道从每颗卫星和距离来确定波的速度。 还提供了根据本发明使用的系统和试剂盒。
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7.发明申请Automated Optimization of Multi-Electrode Pacing for Cardiac Resynchronization 有权用于心脏再同步的多电极起搏的自动优化公开(公告)号：US20080294218A1
公开(公告)日：2008-11-27
申请号：US11909786
申请日：2006-03-31
申请人： George M. Savage , Todd Thompson , Mark J. Zdeblick , Lawrence W. Arne , Olivier Colliou , Benedict James Costello , Fataneh A. Omidvar
发明人： George M. Savage , Todd Thompson , Mark J. Zdeblick , Lawrence W. Arne , Olivier Colliou , Benedict James Costello , Fataneh A. Omidvar
IPC分类号： A61N1/06
CPC分类号： A61N1/3627 , A61N1/08 , A61N1/36185 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/3686 , A61N1/37247
摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.
摘要翻译： 本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。 在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。 起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。 然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。 该系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极发射的起搏信号。
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公开(公告)号：US20080242976A1
公开(公告)日：2008-10-02
申请号：US11664468
申请日：2007-03-30
申请人： Timothy L. Robertson , Olivier Colliou , Benedict J. Costello , George M. Savage , Todd Thompson , Mark J. Zdeblick
发明人： Timothy L. Robertson , Olivier Colliou , Benedict J. Costello , George M. Savage , Todd Thompson , Mark J. Zdeblick
IPC分类号： A61B5/04
CPC分类号： A61B5/1107 , A61B5/686 , A61B2562/046 , A61N1/056 , A61N1/3627 , A61N1/36514 , A61N1/36578 , A61N1/368 , A61N1/3684 , A61N1/375 , A61N1/3752 , A61N1/3756 , A61N2001/0585
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electromechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。 使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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公开(公告)号：US07983751B2
公开(公告)日：2011-07-19
申请号：US12063097
申请日：2006-08-09
IPC分类号： A61N1/00
CPC分类号： A61B5/04011
摘要： A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.
摘要翻译： 用于测量组织中去极化波的传导速度的方法使用位于组织内的第一卫星，并且第二卫星位于组织内距离第一卫星一定距离，例如通过使用去极化波的时间作为 报道从每颗卫星和距离来确定波的速度。 还提供了根据本发明使用的系统和试剂盒。
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公开(公告)号：US20080255629A1
公开(公告)日：2008-10-16
申请号：US11718201
申请日：2005-10-31
申请人： Marc Jenson , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
发明人： Marc Jenson , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了用于评估心脏组织位置例如心脏壁的运动的方法。 在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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