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    PLANAR FLEXURE MEMBERS AND ACTUATORS USING THEM
    3.
    发明申请
    PLANAR FLEXURE MEMBERS AND ACTUATORS USING THEM 有权
    平面灵活性成员和使用它们的执行器

    公开(公告)号：US20170023083A1

    公开(公告)日：2017-01-26

    申请号：US14806807

    申请日：2015-07-23

    申请人： Matthew Knoll ,  Jonathan Bond ,  Robert White ,  Umberto Scarfogliero ,  Andrew Wallace

    发明人： Matthew Knoll ,  Jonathan Bond ,  Robert White ,  Umberto Scarfogliero ,  Andrew Wallace

    IPC分类号： F16F1/02 ,  F16D3/12

    CPC分类号： F16F1/027 ,  B25J17/0225 ,  F16D3/005 ,  F16D3/12 ,  F16D3/62 ,  F16D3/79

    摘要： A planar flexure member for resisting rotation about a central axis thereof includes, in various embodiments, a central portion comprising a plurality of attachment points; and at least one serpentine flexure arm extending from the central portion in a plane. The arm(s) terminate in an arcuate mounting rail that includes a series of attachment points. The rails are positioned in opposition to to each other to partially define and occupy a planar circular envelope radially displaced from but surrounding the central portion of the flexure member. A portion of the serpentine arms may extend to (or substantially to) the envelope between the mounting rails.

    摘要翻译： 在各种实施例中，用于抵抗围绕其中心轴的旋转的平面弯曲构件包括包括多个附接点的中心部分; 以及从平面中的中心部分延伸的至少一个蛇形挠曲臂。 该臂终止于包括一系列连接点的弧形安装轨道。 轨道彼此相对定位，以部分地限定和占据从弯曲构件的中心部分径向偏移但围绕着弯曲构件的中心部分的平面圆形包围。 蛇形臂的一部分可以延伸到（或基本上）到安装轨道之间的封套。

    Implantable cardiac motion powered piezoelectric energy source
    5.
    发明授权
    Implantable cardiac motion powered piezoelectric energy source 有权
    植入式心脏动力电动压电能源

    公开(公告)号：US07729768B2

    公开(公告)日：2010-06-01

    申请号：US11385986

    申请日：2006-03-20

    申请人： Robert White ,  George Savage ,  Mark Zdeblick

    发明人： Robert White ,  George Savage ,  Mark Zdeblick

    IPC分类号： A61N1/00

    CPC分类号： H01L41/1136 ,  A61N1/30 ,  A61N1/32 ,  A61N1/3785

    摘要： Implantable cardiac motion powered piezoelectric energy sources are provided. An aspects of embodiments of the subject implantable energy sources is that they include a piezoelectric transducer that converts cardiac mechanical energy to electrical energy. The subject energy sources find use in a variety of applications, including providing power to a wide range of implantable devices.

    摘要翻译： 提供了植入式心脏运动动力压电能源。 可植入能源的实施方案的一个方面是它们包括将心脏机械能转化为电能的压电换能器。 主题能源可用于各种应用，包括向广泛的可植入装置提供动力。

    Retinal dystrophin transgene and methods of use thereof
    7.
    发明申请
    Retinal dystrophin transgene and methods of use thereof 审中-公开
    视网膜肌营养不良蛋白转基因及其使用方法

    公开(公告)号：US20080044393A1

    公开(公告)日：2008-02-21

    申请号：US11050911

    申请日：2005-02-04

    申请人： Robert White ,  Roger Gaedigk ,  Kathleen Fitzgerald-Gustafson

    发明人： Robert White ,  Roger Gaedigk ,  Kathleen Fitzgerald-Gustafson

    IPC分类号： A61K31/70 ,  A01K67/00 ,  A61K35/00 ,  A61P43/00 ,  C07H21/04 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C07K14/4708 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  C12N15/8509 ,  C12N2830/008

    摘要： Duchenne muscular dystrophy (DMD) is a progressive muscle disease that is caused by severe defects in the dystrophin gene and results in the patient's death by the third decade. The present invention utilizes the Double Mutant mice (DM) as an appropriate human model for DMD as these mice are deficient for both dystrophin and utrophin (mdx/+, utrn −/−), die at 3 months of age and suffer from severe muscle weakness, pronounced growth retardation, kyphosis, weight loss, slack posture, and immobility. Expression from a transgene of novel human retinal dystrophin Dp260 was shown to prevent premature death and reduce the severe muscular dystrophy phenotype to a mild clinical myopathy. Electromyography, histology, radiography, magnetic resonance imaging, and behavior studies concluded that DM transgenic mice grew normally, had normal spinal curvature and mobility, and had reduced muscle pathology. EMG and histologic data from transgenic DM mice showed decreased abnormalities to levels typical of mild myopathy, while the DM mice exhibited severe abnormalities commonly seen in human dystrophinopathies. The transgenic DM mice also had measurable movement levels comparable to those of untreated mdx mice and controls.

    摘要翻译： Duchenne肌营养不良（DMD）是由肌营养不良蛋白基因的严重缺陷引起的进行性肌肉疾病，并导致患者在第三个十年内死亡。 本发明利用双重突变体小鼠（DM）作为DMD的合适人类模型，因为这些小鼠在肌营养不良蛋白和utrophin（mdx / +，utrn - / - ）中都是缺陷的，在3个月龄时死亡，并且患有严重的肌肉 虚弱，发育迟缓，驼背，体重减轻，松弛姿势和不动。 显示来自新型人视网膜肌营养不良蛋白Dp260的转基因的表达可预防过早死亡，并将严重的肌营养不良症表型降低至轻度临床肌病。 肌电图，组织学，放射成像，磁共振成像和行为研究得出结论，DM转基因小鼠正常生长，脊柱弯曲和移动性正常，肌肉病理学减少。 来自转基因DM小鼠的EMG和组织学数据显示轻度肌病典型的异常降低，而DM小鼠在人类肌营养不良症中常见的严重异常。 转基因小鼠也具有与未处理的mdx小鼠和对照相当的可测量运动水平。

    Magnetic sifter
    8.
    发明申请
    Magnetic sifter 有权
    磁选机

    公开(公告)号：US20070181466A1

    公开(公告)日：2007-08-09

    申请号：US11595818

    申请日：2006-11-09

    申请人： Shan Wang ,  Nader Pourmand ,  Robert White

    发明人： Shan Wang ,  Nader Pourmand ,  Robert White

    IPC分类号： B03C1/30 ,  B03C1/00

    CPC分类号： B03C1/0335 ,  B03C2201/18 ,  B03C2201/22

    摘要： The present invention provides a magnetic sifter that is small in scale, enables three-dimensional flow in a direction normal to the substrate, allows relatively higher capture rates and higher flow rates, and provides a relatively easy method of releasing captured biomolecules. The magnetic sifter includes at least one substrate. Each substrate contains a plurality of slits, each of which extends through the substrate. The sifter also includes a plurality of magnets attached to the bottom surface of the substrate. These magnets are located proximal to the openings of the slits. An electromagnetic source controls the magnitude and direction of magnetic field gradient generated by the magnets. Either one device may be used, or multiple devices may be used in series. In addition, the magnetic sifter may be used in connection with a detection chamber.

    摘要翻译： 本发明提供一种规模小的磁选筛机，使得能够沿垂直于基底的方向进行三维流动，允许相对较高的捕获率和较高的流速，并且提供了一种相对容易的释放捕获的生物分子的方法。 磁选机包括至少一个衬底。 每个基板包含多个狭缝，每个狭缝延伸穿过基板。 筛子还包括附着到基底的底表面的多个磁体。 这些磁体位于缝隙的开口附近。 电磁源控制由磁体产生的磁场梯度的大小和方向。 可以使用一个设备，或者可以串联使用多个设备。 此外，磁选机可以与检测室结合使用。

    TOWED IMPLEMENT DRAFT FORCE SENSOR
    9.
    发明申请
    TOWED IMPLEMENT DRAFT FORCE SENSOR 有权
    强制执行力传感器

    公开(公告)号：US20060219417A1

    公开(公告)日：2006-10-05

    申请号：US11086619

    申请日：2005-03-22

    申请人： Raymond Thompson ,  Peter Kosmicki ,  Jeffrey Dawson ,  Scott Cook ,  Edwin Kreis ,  Michael Kollath ,  Joe Schutte ,  Robert White

    发明人： Raymond Thompson ,  Peter Kosmicki ,  Jeffrey Dawson ,  Scott Cook ,  Edwin Kreis ,  Michael Kollath ,  Joe Schutte ,  Robert White

    IPC分类号： A01B63/112

    CPC分类号： A01B59/042 ,  A01B63/14 ,  G01L5/136

    摘要： A draft force sensor is provided for a coupling member coupled between a towing vehicle and a towed earth engaging implement, such as a scraper. The draft force sensor includes first and second bores extending through the coupling member. Each bore has a horizontal axis which extends perpendicular to a main fore-and-aft axis of the coupling member. The second bore is positioned above the first bore and spaced apart from the first bore. Each of the bores is surrounded by an outer cylindrical wall. Four electrical strain gauges are spaced apart and placed on the wall of each of the bores. A center line bisects an axis line which extends between the axes of the first and second bores. The axis of each bore is spaced apart from the center line by a distance which is less than a diameter of the bores. The strain gauges are connected electrically in a circuit which generates a draft force signal in response to draft forces applied to the coupling member.

    摘要翻译： 提供牵引力传感器用于耦合在牵引车辆和拖曳地球接合工具（例如刮刀）之间的联接构件。 牵引力传感器包括延伸穿过联接构件的第一和第二孔。 每个孔具有垂直于联接构件的主要前后轴线延伸的水平轴线。 第二孔位于第一孔的上方并与第一孔隔开。 每个孔都被一个外圆柱形的墙围起来。 四个电气应变计间隔开并放置在每个孔的壁上。 中心线将在第一和第二孔的轴线之间延伸的轴线平分。 每个孔的轴线与中心线间隔一个小于孔直径的距离。 应变计在电路中电连接，该电路响应于施加到联接构件的牵引力而产生牵伸力信号。

    Implantable cardiac motion powered piezoelectric energy source
    10.
    发明申请
    Implantable cardiac motion powered piezoelectric energy source 有权
    植入式心脏动力电动压电能源

    公开(公告)号：US20060217776A1

    公开(公告)日：2006-09-28

    申请号：US11385986

    申请日：2006-03-20

    申请人： Robert White ,  George Savage ,  Mark Zdeblick

    发明人： Robert White ,  George Savage ,  Mark Zdeblick

    IPC分类号： A61N1/00

    CPC分类号： H01L41/1136 ,  A61N1/30 ,  A61N1/32 ,  A61N1/3785

    摘要： Implantable cardiac motion powered piezoelectric energy sources are provided. Aspects of embodiments of the subject implantable energy sources is that they include a piezoelectric transducer that converts cardiac mechanical energy to electrical energy. The subject energy sources find use in a variety of applications, including providing power to a wide range of implantable devices.

    摘要翻译： 提供了植入式心脏运动动力压电能源。 可植入能源的实施方案的方面是它们包括将心脏机械能转化为电能的压电换能器。 主题能源可用于各种应用，包括向广泛的可植入装置提供动力。