公开(公告)号：US08738154B2

公开(公告)日：2014-05-27

申请号：US13115031

申请日：2011-05-24

Applicant: Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

Inventor： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

IPC: A61N1/05

CPC classification number: A61N1/375 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36185

Abstract: Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

Abstract translation: 提供可植入的刺激装置。 器件的方面包括配置用于神经刺激的复用多电极部件。 多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。 卫星结构包括可操作地耦合到一个或多个电极的密封的集成电路控制器。 还提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。

公开(公告)号：US20130018434A1

公开(公告)日：2013-01-17

申请号：US13619055

申请日：2012-09-14

Applicant: Mark J. Zdeblick ,  Benedict James Costello ,  Jeremy Frank ,  Marc Jensen ,  Todd Thompson ,  Mohammed Z. Islam

Inventor： Mark J. Zdeblick ,  Benedict James Costello ,  Jeremy Frank ,  Marc Jensen ,  Todd Thompson ,  Mohammed Z. Islam

IPC: A61N1/375 ,  H01R43/00

CPC classification number: A61N1/05 ,  H01L21/561 ,  H01L23/3107 ,  H01L24/63 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01024 ,  H01L2924/01033 ,  H01L2924/01044 ,  H01L2924/01045 ,  H01L2924/01047 ,  H01L2924/01049 ,  H01L2924/01074 ,  H01L2924/01076 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/15787 ,  Y10T29/49117 ,  H01L2924/00

Abstract: An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.

Abstract translation: 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。

公开(公告)号：US08195308B2

公开(公告)日：2012-06-05

申请号：US11794016

申请日：2005-12-22

Applicant: Jeremy Frank ,  Vladimier Gelfandbein ,  Marc Jensen ,  Mark J. Zdeblick ,  Benedict James Costello

Inventor： Jeremy Frank ,  Vladimier Gelfandbein ,  Marc Jensen ,  Mark J. Zdeblick ,  Benedict James Costello

IPC: A61N1/05

CPC classification number: A61N1/375 ,  A61N1/05 ,  A61N1/37205 ,  A61N1/3756

Abstract: Implantable hermetically sealed structures and methods for making the same. Devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems are included.

Abstract translation: 可植入的密封结构及其制造方法。 还包括包括密封结构在内的装置，系统和试剂盒以及使用这些装置和系统的方法。

公开(公告)号：US20120109112A1

公开(公告)日：2012-05-03

申请号：US13228344

申请日：2011-09-08

Applicant: Mark Zdeblick ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

Inventor： Mark Zdeblick ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

IPC: A61M37/00 ,  A61N1/36

CPC classification number: A61N1/37217 ,  A61B5/073 ,  A61J3/06 ,  A61J3/07 ,  A61M5/1723 ,  A61M31/002

Abstract: An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The responder module may receive and process the effector instruction, resulting in a response by the therapeutic device. Examples of responses by therapeutic device include activating a therapy, deactivating a therapy, modulating a therapy, and discontinuing a therapy.

Abstract translation: 提供了一种可摄取的治疗激活剂系统和方法。 在一个方面，可摄入治疗激活剂包括具有效应器模块的可摄取装置，以发送效应器指令和与治疗装置相关联的应答模块。 应答器模块可以接收并处理效应器指令，导致治疗装置的响应。 治疗装置的反应的实例包括激活治疗，停用治疗，调节治疗和停止治疗。

公开(公告)号：US08055353B2

公开(公告)日：2011-11-08

申请号：US12370494

申请日：2009-02-12

Applicant: Marc Kreidler ,  David Huynh ,  Marc Jensen

Inventor： Marc Kreidler ,  David Huynh ,  Marc Jensen

IPC: A61N1/00

CPC classification number: A61N1/05 ,  A61B5/042 ,  A61N1/0551 ,  A61N1/056

Abstract: Medical carriers that include a low-impedance conductor are provided. The low-impedance conductors are configured to provide electrical conductivity along a length of the medical carrier. An aspect of the low-impedance conductors is the presence of a longitudinally extended region configured as a non-coiled repetitive pattern that imparts fatigue resistance to the longitudinally extended region. Also provided are systems and methods of making the medical carriers, as well as methods of using the medical carriers.

Abstract translation: 提供包括低阻抗导体的医疗载体。 低阻抗导体被配置为沿医疗载体的长度提供导电性。 低阻抗导体的一个方面是存在构造为非卷曲重复图案的纵向延伸区域，其赋予纵向延伸区域耐疲劳性。 还提供了制造医疗载体的系统和方法，以及使用医疗载体的方法。

公开(公告)号：US20110270052A1

公开(公告)日：2011-11-03

申请号：US13141048

申请日：2010-01-06

Applicant: Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

Inventor： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

IPC: A61B5/07

CPC classification number: A61B5/073 ,  A61B5/0002 ,  A61B5/021 ,  A61B5/024 ,  A61B5/1112 ,  A61B5/486 ,  A61B5/6833 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/60 ,  G16H20/00 ,  G16H20/10 ,  H04B13/005

Abstract: Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.

Abstract translation: 提供了用于获取有助于支持患者实施和遵守医学上规定的治疗方案的信息的方法，装置和系统。 该疗法可以包括生物反馈方法和/或个性化治疗方面。 一种方法包括以下步骤：由接收装置接收与可摄取事件标记相关联的生物特征信息; 通过具有微处理器的计算设备分析生物特征信息; 以及至少部分地基于分析和/或将生物反馈技术集成到患者治疗或活动中来确定治疗推荐。 一种系统包括用于接收与可摄取事件标记相关联的生物特征信息的生物特征信息模块; 分析生物特征信息的分析模块; 以及确定模块，用于至少部分地基于分析来可选地确定和传达治疗推荐。

公开(公告)号：US07974705B2

公开(公告)日：2011-07-05

申请号：US12665030

申请日：2009-11-13

Applicant: Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

Inventor： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

IPC: A61N1/05

CPC classification number: A61N1/375 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36185

Abstract: Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

Abstract translation: 提供可植入的刺激装置。 器件的方面包括配置用于神经刺激的复用多电极部件。 多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。 卫星结构包括可操作地耦合到一个或多个电极的密封的集成电路控制器。 还提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。

公开(公告)号：US20110022124A1

公开(公告)日：2011-01-27

申请号：US12665030

申请日：2009-11-13

Applicant: Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

Inventor： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

IPC: A61N1/00

CPC classification number: A61N1/375 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36185

Abstract: Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

Abstract translation: 提供可植入的刺激装置。 器件的方面包括配置用于神经刺激的复用多电极部件。 多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。 卫星结构包括可操作地耦合到一个或多个电极的密封的集成电路控制器。 还提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。

公开(公告)号：US20100016928A1

公开(公告)日：2010-01-21

申请号：US12296654

申请日：2007-04-12

Applicant: Mark J. Zdeblick ,  Benedict Costello ,  Jeremy Frank ,  Marc Jensen ,  Todd Thompson ,  Mohammed Z. Islam

Inventor： Mark J. Zdeblick ,  Benedict Costello ,  Jeremy Frank ,  Marc Jensen ,  Todd Thompson ,  Mohammed Z. Islam

IPC: A61N1/05

CPC classification number: A61N1/05 ,  H01L21/561 ,  H01L23/3107 ,  H01L24/63 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01024 ,  H01L2924/01033 ,  H01L2924/01044 ,  H01L2924/01045 ,  H01L2924/01047 ,  H01L2924/01049 ,  H01L2924/01074 ,  H01L2924/01076 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/15787 ,  Y10T29/49117 ,  H01L2924/00

Abstract: An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.

Abstract translation: 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。

公开(公告)号：US20090299447A1

公开(公告)日：2009-12-03

申请号：US11917992

申请日：2006-06-30

Applicant: Marc Jensen ,  Olivier Colliou ,  Benedict Costello ,  Mark Zdeblick ,  Todd Thompson ,  George Savage ,  Andrew Thompson

Inventor： Marc Jensen ,  Olivier Colliou ,  Benedict Costello ,  Mark Zdeblick ,  Todd Thompson ,  George Savage ,  Andrew Thompson

IPC: A61N1/05

CPC classification number: A61N1/0587

Abstract: Minimally invasive deployable epicardial array devices are provided. The devices include deployable platform comprising two or more effectors, such as sensors and actuators, where the devices are configured to be deployed at an epicardial location via a minimally invasive, e.g., sub-xiphoid approach. In embodiments of the present invention, at least one area of the electrode patch is an electrical control area that comprises a series of effectors, e.g., sensors and/or electrodes. Other embodiments provide localized physical constraint and dynamic mechanical stimulation of the heart to effectuate physical and biological responses. Still other embodiments provide both of these functions. Also provided are methods of using the devices, as well as systems and kits that include the devices.

Abstract translation: 提供微创可部署的心外阵列器件。 这些装置包括包括两个或更多个效应器（诸如传感器和致动器）的可展开平台，其中装置被配置成经由微创例如亚剑突方法部署在心外膜位置。 在本发明的实施例中，电极贴片的至少一个区域是包括一系列效应器例如传感器和/或电极的电控制区域。 其他实施例提供心脏的局部物理约束和动态机械刺激以实现物理和生物反应。 其他实施例提供这两个功能。 还提供了使用这些设备的方法，以及包括设备的系统和套件。