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公开(公告)号：US08633314B2
公开(公告)日：2014-01-21
申请号：US13404137
申请日：2012-02-24
Applicant: Stephen Bierlmaier , Michael Christie , R. Scott Field , R. Curtis Haltiwanger , Linli He , Martin J. Jacobs , Michael Kress , Robert E. McKean , Dale R. Mowrey , Joseph Petraitis , Mehran Yazdanian , Veronique Courvoisier
Inventor： Stephen Bierlmaier , Michael Christie , Laurent Courvoisier , R. Scott Field , R. Curtis Haltiwanger , Linli He , Martin J. Jacobs , Michael Kress , Robert E. McKean , Dale R. Mowrey , Joseph Petraitis , Mehran Yazdanian
IPC: C07D295/12
CPC classification number: C07D487/04
Abstract: The present invention provides alternative forms of Compound I, processes to reproducibly make them and methods of treating patients using them.
Abstract translation: 本发明提供了替代形式的化合物I，可重复制备它们的方法和使用它们治疗患者的方法。
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公开(公告)号：US20120214998A1
公开(公告)日：2012-08-23
申请号：US13404137
申请日：2012-02-24
Applicant: Stephen Bierlmaier , Michael Christie , Laurent Courvoisier , Veronique Courvoisier , R. Scott Field , R. Curtis Haltiwanger , Linli He , Martin J. Jacobs , Michael Kress , Robert E. McKean , Dale R. Mowrey , Joseph Petraitis , Mehran Yazdanian
Inventor： Stephen Bierlmaier , Michael Christie , Laurent Courvoisier , Veronique Courvoisier , R. Scott Field , R. Curtis Haltiwanger , Linli He , Martin J. Jacobs , Michael Kress , Robert E. McKean , Dale R. Mowrey , Joseph Petraitis , Mehran Yazdanian
IPC: C07D295/12
CPC classification number: C07D487/04
Abstract: The present invention provides alternative forms of Compound I, processes to reproducibly make them and methods of treating patients using them.
Abstract translation: 本发明提供了替代形式的化合物I，可重复制备它们的方法和使用它们治疗患者的方法。
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公开(公告)号：US4849447A
公开(公告)日：1989-07-18
申请号：US108539
申请日：1987-10-13
Applicant: Martin J. Jacobs
Inventor： Martin J. Jacobs
CPC classification number: C07D313/00
Abstract: Compounds having the formula: ##STR1## wherein R.sub.1 is hydrogen, or an alkyl from about 1 to about 3 carbon atoms; R.sub.2 is hydrogen, or an alkyl from about 1 to about 18 carbon atoms; R.sub.3 is keto, or hydroxyl; and R.sub.4 is hydrogen, an alkyl from about 1 to about 4 carbon atoms, hydroxyl, or amino are synthesized and administered to animals as anabolic agents.
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公开(公告)号：US07704975B2
公开(公告)日：2010-04-27
申请号：US11604996
申请日：2006-11-28
Applicant: Martin J. Jacobs , Piyush R. Patel
Inventor： Martin J. Jacobs , Piyush R. Patel
IPC: A61K31/724 , A61K31/165
CPC classification number: A61K31/165 , A61K47/6951 , B82Y5/00
Abstract: Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which are taste-masked and suitable for oral consumption in an aqueous solution.
Abstract translation: 公开了莫达非尼化合物与环糊精的混合物，其使用方法及其组合物，以及包含莫达非尼化合物和环糊精的复合物，所述复合物和环糊精被掩味并适合于在水溶液中口服使用。
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公开(公告)号：US20090227650A1
公开(公告)日：2009-09-10
申请号：US12355284
申请日：2009-01-16
Applicant: Stephen Bierlmaier , Laurent Courvoisier , Raymond Scott Field , R.Curtis Haltiwanger , Martin J. Jacobs , Robert E. McKean , Mehran Yazdanian
Inventor： Stephen Bierlmaier , Laurent Courvoisier , Raymond Scott Field , R.Curtis Haltiwanger , Martin J. Jacobs , Robert E. McKean , Mehran Yazdanian
IPC: A61K31/407 , C07D245/04 , A61P35/02
CPC classification number: C07D498/08
Abstract: Novel crystalline forms of lestaurtinib are described, including six co-crystal forms, nineteen solvate forms, three anhydrate forms and one hemihydrate form. Methods of their preparation and use are also described.
Abstract translation: 描述了新颖的柳叶刀的结晶形式，包括六种共晶形式，十九种溶剂合物形式，三种无水形式和一种半水合物形式。 还描述了它们的制备和使用方法。
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Patent Agency Ranking
公开(公告)号：US4416734A
公开(公告)日：1983-11-22
申请号：US262078
申请日：1981-05-11
Applicant: Martin J. Jacobs
Inventor： Martin J. Jacobs
IPC: B01D3/36 , B01D9/00 , B01D12/00 , C07C201/16 , C07C79/18
CPC classification number: C07C201/16 , B01D12/00 , B01D3/36 , B01D9/0004
Abstract: A process for the separation of a dissolved solid from an aqueous solution containing it, comprising the steps of (a) adding thereto an organic liquid which is a poor solvent for the dissolved solid and which forms an azeotrope with water, (b) subjecting the mixture to azeotropic distillation to separate at least a major portion of the water, (c) cooling the mixture thereby causing substantially complete separation of the dissolved solids, and (d) separating same from the mother liquor.
Abstract translation: 一种从含有溶解的固体的水溶液中分离溶解的固体的方法，包括以下步骤：（a）向其中加入作为溶解的固体的不良溶剂并与水形成共沸物的有机液体，（b） 混合物以共沸蒸馏以分离至少大部分水，（c）冷却混合物，从而使溶解的固体基本上完全分离，和（d）将其从母液中分离出来。
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公开(公告)号：US06489363B2
公开(公告)日：2002-12-03
申请号：US09974473
申请日：2001-10-10
Applicant: Martin J. Jacobs , Bradley T. McIntyre , Piyush R. Patel
Inventor： Martin J. Jacobs , Bradley T. McIntyre , Piyush R. Patel
IPC: A61K3116
CPC classification number: A61K9/0095 , A61K9/4858 , A61K31/165 , A61K47/10 , A61K47/22
Abstract: Pharmaceutical compositions of modafinil compounds, and pharmaceutical, non-aqueous compositions of modafinil compounds in organic solvents are disclosed, along with their use in the treatment of diseases.
Abstract translation: 莫达非尼化合物的药物组合物和莫达非尼化合物在有机溶剂中的药物非水性组合物以及它们在治疗疾病中的用途。
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公开(公告)号：US4842862A
公开(公告)日：1989-06-27
申请号：US881926
申请日：1986-07-03
Applicant: Martin J. Jacobs , Carl K. Edwards, III , Paula Myers-Keith
Inventor： Martin J. Jacobs , Carl K. Edwards, III , Paula Myers-Keith
IPC: A61K31/335
CPC classification number: A61K31/335
Abstract: The Resorcylic Acid Lactone (RAL) derivatives zearalenone, zearalanone, zearalene, zearalane, zearalenol, zearalanol, and dideoxyzearalane are administered to vertebrates to non-specifically stimulate the immune system.
Abstract translation: 向脊椎动物施用间叶酸内酯（RAL）衍生物玉米赤霉烯酮，玉米赤霉烯酮，玉米赤霉烯，玉米赤霉烯，玉米赤霉烯醇，玉米赤霉烯醇和双脱氧山梨醇，以非特异性刺激免疫系统。
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公开(公告)号：US4418226A
公开(公告)日：1983-11-29
申请号：US432602
申请日：1982-10-04
Applicant: Martin J. Jacobs
Inventor： Martin J. Jacobs
CPC classification number: C07C41/38 , C07C29/78 , C07C31/245
Abstract: Aqueous mother liquor from which pentaerythritol has been removed by crystallization is extracted with tetrahydrofuran to remove formals, and the raffinate comprising pentaerythritol is recycled to the crystallization process.
Abstract translation: 通过结晶将季戊四醇除去的含水母液用四氢呋喃萃取以除去甲醛，并将包含季戊四醇的残液物再循环至结晶过程。
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公开(公告)号：US4196295A
公开(公告)日：1980-04-01
申请号：US910711
申请日：1978-05-30
Applicant: Martin J. Jacobs
Inventor： Martin J. Jacobs
IPC: C07D295/073 , C07D295/06
CPC classification number: C07D295/073
Abstract: Compounds of the following formula and a method for their preparation are disclosed: ##STR1## wherein Ar is substituted or unsubstituted phenyl, R, R' and R" may be similar or dissimilar and are each selected from the group consisting of lower alkyl of from 1 to about 5 carbon atoms. The compounds of this invention are useful as antimicrobial agents.
Abstract translation: 公开了下式的化合物及其制备方法：其中Ar是取代或未取代的苯基，R，R'和R“可以相似或不相似，并且各自选自下列基团的低级烷基： 1至约5个碳原子。 本发明的化合物可用作抗微生物剂。
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