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    Delivering genetic material to a stimulation site
    2.
    发明申请
    Delivering genetic material to a stimulation site 审中-公开
    将遗传物质提供给刺激部位

    公开(公告)号：US20050059999A1

    公开(公告)日：2005-03-17

    申请号：US10663570

    申请日：2003-09-15

    申请人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

    发明人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

    IPC分类号： A61K48/00 ,  A61N1/05 ,  A61N1/362

    CPC分类号： A61N1/0568 ,  A61K48/0008 ,  A61K48/0041 ,  A61K48/0083

    摘要： Delivery of genetic material to a stimulation site causes transgene expression by tissue at the stimulation site. In some embodiments, the delivered genetic material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at the stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation site via a stimulation lead. A stimulation lead for delivering genetic material to a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.

    摘要翻译： 将遗传物质递送至刺激部位会在刺激部位引起组织的转基因表达。 在一些实施方案中，递送的遗传物质导致蛋白质（例如连接蛋白，间隙连接和离子通道）的表达增加，以增加刺激部位组织的电导率。 在一些实施方案中，递送的遗传物质导致金属蛋白酶，抗炎剂或免疫抑制剂的表达。 遗传物质通过刺激引线输送到刺激部位。 用于将遗传物质递送至刺激部位的刺激引线包括含有聚合物基质的腔室。 基质吸收遗传物质并将遗传物质洗脱到刺激部位。

    Means for increasing implantable medical device electrode surface area
    4.
    发明申请
    Means for increasing implantable medical device electrode surface area 有权
    增加植入式医疗器械电极表面积的手段

    公开(公告)号：US20060030893A1

    公开(公告)日：2006-02-09

    申请号：US10914303

    申请日：2004-08-09

    申请人： Timothy Laske ,  Gonzalo Martinez ,  Lea Nygren

    发明人： Timothy Laske ,  Gonzalo Martinez ,  Lea Nygren

    IPC分类号： A61N1/375

    CPC分类号： A61N1/375 ,  A61N1/3756

    摘要： A surface area of an IMD electrode is increased by forming a conductive layer over an external portion of a sidewall of an IMD connector header and electrically coupling the conductive layer of the connector header to a conductive mounting surface of a hermetically sealed IMD housing; wherein the conductive mounting surface is an extension of an external conductive surface of the IMD, which external conductive surface forms the IMD electrode that is increased in surface area by the conductive layer formed over the connector header.

    摘要翻译： 通过在IMD连接器集管的侧壁的外部部分上形成导电层并将连接器集管的导电层电耦合到密封的IMD壳体的导电安装表面来增加IMD电极的表面积; 其中所述导电安装表面是所述IMD的外部导电表面的延伸部，所述外部导电表面形成所述IMD电极，所述IMD电极通过形成在所述连接器插头上的导电层而在表面积上增加。

    Pacing method
    6.
    发明申请
    Pacing method 有权

    公开(公告)号：US20060142814A1

    公开(公告)日：2006-06-29

    申请号：US10782420

    申请日：2004-02-19

    申请人： Timothy Laske ,  Paul Iaizzo

    发明人： Timothy Laske ,  Paul Iaizzo

    IPC分类号： A61N1/368

    CPC分类号： A61N1/056 ,  A61N1/0573

    摘要： A method for delivering physiological pacing includes selecting an electrode implant site within an interventricular septal zone, which is in proximity to the bundle of His where pacing stimulation results in a rhythm breaking out at an intrinsic location, and wherein a ratio of sensed P-wave amplitude to sensed R-wave amplitude is less than approximately 0.5 and a pacing threshold is less than or equal to approximately 1.5 volts.

    Medical electrical lead anchoring
    7.
    发明申请
    Medical electrical lead anchoring 有权
    医用电气导线锚定

    公开(公告)号：US20050033395A1

    公开(公告)日：2005-02-10

    申请号：US10664995

    申请日：2003-09-17

    申请人： Kevin Seifert ,  Timothy Laske

    发明人： Kevin Seifert ,  Timothy Laske

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0587 ,  A61N1/059 ,  A61N2001/0578

    摘要： A lead body of a medical electrical lead includes a distal end, a first elongated insulated conductor extending toward the distal end and a first electrode coupled to the conductor. A second elongated insulated conductor includes a first portion extending within the lead body to the distal end and a second portion extending distally from the distal end of the lead body where it is terminated by a tissue anchor on which a second electrode is mounted; the tissue anchor includes a surface for receiving a push force from an insertion tool, which is adapted to insert the anchor within a segment of tissue such that the first electrode of the lead body is in close proximity to the segment of tissue.

    摘要翻译： 医疗电线的引线体包括远端，朝向远端延伸的第一细长绝缘导体和耦合到导体的第一电极。 第二细长绝缘导体包括在引线主体内延伸到远端的第一部分和从引线主体的远端向远端延伸的第二部分，其中第二部分由其上安装有第二电极的组织锚固件终止; 组织锚固件包括用于接收来自插入工具的推力的表面，其适于将锚固件插入组织段内，使得引线主体的第一电极紧邻组织段。

    Variable EGM filtering and fixation prediction
    8.
    发明申请
    Variable EGM filtering and fixation prediction 有权
    可变EGM过滤和固定预测

    公开(公告)号：US20050015116A1

    公开(公告)日：2005-01-20

    申请号：US10821451

    申请日：2004-04-09

    申请人： Timothy Laske ,  Thomas Ahern

    发明人： Timothy Laske ,  Thomas Ahern

    IPC分类号： A61N1/08 ,  A61N1/37

    CPC分类号： A61N1/08 ,  A61N2001/083

    摘要： An IMD includes a variable sense amplifier that can be adjusted to counteract the variability created in EGM's due to lead maturation. The effects of lead maturation are either predictively assumed or individually assessed on a given patient. The sense amplifier is then adjusted to assure positive identification of desired events and eliminate unwanted events.

    摘要翻译： IMD包括可调节的可变感测放大器，以抵消由于铅成熟引起的EGM中产生的变异性。 铅成熟的影响可以在给定的患者中被预测地假定或单独评估。 然后调整读出放大器以确保所需事件的正确识别并消除不需要的事件。

    Clinical tool for structure localization
    10.
    发明申请
    Clinical tool for structure localization 有权
    结构定位临床工具

    公开(公告)号：US20050148850A1

    公开(公告)日：2005-07-07

    申请号：US10987815

    申请日：2004-11-12

    申请人： Ryan Lahm ,  Walton Baxter ,  Josee Morissette ,  Timothy Laske

    发明人： Ryan Lahm ,  Walton Baxter ,  Josee Morissette ,  Timothy Laske

    IPC分类号： A61B5/05 ,  A61B5/06

    CPC分类号： A61B5/06 ,  A61B5/065 ,  A61B5/7285

    摘要： A method for localizing an internal body structure during an image-guided procedure that includes obtaining a three dimensional image of a body portion containing a targeted structure and selected reference structures; determining a set of landmark point coordinates for defining the location of each of the targeted and reference structures; computing triangulation parameters relating the location of the landmark points for the targeted structure and the reference structures; and, during an image-guided procedure, using the computed triangulation parameters to plot an estimated location of the targeted structure on an intra-operative image in which the reference structures have been identified.

    摘要翻译： 一种用于在图像引导过程中定位内部身体结构的方法，包括获得包含目标结构和所选择的参考结构的身体部分的三维图像; 确定用于定义每个所述目标和参考结构的位置的一组地标点坐标; 计算与目标结构和参考结构的地标点的位置相关的三角测量参数; 并且在图像引导过程期间，使用所计算的三角测量参数来绘制目标结构在已经识别了参考结构的手术中图像上的估计位置。