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24 条记录 (耗时 0.026 秒)

    Indole derivatives
    5.
    发明授权
    Indole derivatives 失效
    吲哚衍生物

    公开(公告)号：US5312829A

    公开(公告)日：1994-05-17

    申请号：US956579

    申请日：1992-10-06

    申请人： Satoshi Okada ,  Kozo Sawada ,  Natsuko Kayakiri ,  Yuki Saitoh ,  Hirokazu Tanaka ,  Masashi Hashimoto

    发明人： Satoshi Okada ,  Kozo Sawada ,  Natsuko Kayakiri ,  Yuki Saitoh ,  Hirokazu Tanaka ,  Masashi Hashimoto

    IPC分类号： C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D209/10 ,  A61K31/405 ,  C07D405/04

    CPC分类号： C07D403/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D413/10 ,  C07D417/10

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is carboxy or pharmaceutically acceptable salts and esters thereof;R.sup.2 is hydrogen, lower alkyl or halogen;R.sup.3 is phenyl, naphthyl, phenyl or naphthyl each substituted by from one to three C.sub.1-6 alkyl groups, mono-, di- or triphenyl (C.sub.1-6)alkyl; or substituted mono-, di- or triphenyl (C.sub.1-6) alkyl;A is lower alkylene which may be substituted by oxo or lower alkenylene,Q is carbonyl or lower alkylene,X is ##STR2## in which R.sup.4 is hydrogen or C.sub.1-6 alkyl, andR.sup.5 is hydrogen, C.sub.1-6 alkyl or Y--Z--R.sup.3,Y is a bond or lower alkylene,Z is lower alkylene ##STR3## in which R.sup.6 is hydrogen, (C.sub.1 -C.sub.6) alkyl, mono-, di- or triphenyl(C.sub.1-10) alkyl, C.sub.1-6 alkyl or lower alkoxycarbonyl substituted mono-, di- or triphenyl(C.sub.1-6)alkyl or pharmaceutically acceptable carboxylic acid acyl, and pharmaceutically acceptable salts thereof. The compound is useful as a testosterone 5.alpha.-reductase inhibitor.

    摘要翻译： 下式的化合物：其中R 1是羧基或其药学上可接受的盐和酯; R2是氢，低级烷基或卤素; R 3为苯基，萘基，苯基或萘基，各自被一至三个C 1-6烷基，单 - ，二 - 或三苯基（C 1-6）烷基取代; 或取代的单 - ，二 - 或三苯基（C 1-6）烷基; A是可被氧代或低级亚烯基取代的低级亚烷基，Q是羰基或低级亚烷基，X是其中R 4是氢或C 1-6烷基，R 5是氢，C 1-6烷基或YZ-R 3 ，Y为键或低级亚烷基，Z为低级亚烷基，其中R6为氢，（C1-C6）烷基，单 - ，二 - 或三苯基（C1-10）烷基，C1-6烷基或低级烷氧基羰基 取代的单 - ，二 - 或三苯基（C 1-6）烷基或药学上可接受的羧酸酰基及其药学上可接受的盐。 该化合物可用作睾酮5α-还原酶抑制剂。

    Aqueous resin composition
    10.
    发明授权
    Aqueous resin composition 失效
    水性树脂组合物

    公开(公告)号：US4436849A

    公开(公告)日：1984-03-13

    申请号：US431080

    申请日：1982-09-30

    申请人： Tetsuo Aihara ,  Yasuharu Nakayama ,  Koichi Umeyama ,  Kozo Sawada ,  Masaaki Shinohara

    发明人： Tetsuo Aihara ,  Yasuharu Nakayama ,  Koichi Umeyama ,  Kozo Sawada ,  Masaaki Shinohara

    IPC分类号： C08F2/26 ,  C08G63/685 ,  C09D167/08 ,  C08L67/08 ,  C09D3/68

    CPC分类号： C08G63/6854 ,  C09D167/08

    摘要： An aqueous resin composition comprising a neutralization product of an isocyanurate group-containing maleinized alkyd resin having an acid value of 5 to 65 in an aqueous medium, said maleinized alkyd resin being prepared by maleinizing an alkyd resin having an acid value of not more than 10 and a hydroxyl value of not more than 10 which is the product of condensation reaction of(A) 20 to 60% by weight of at least one of drying or semi-drying oils and fatty acids,(B) 10 to 45% by weight of at least one tris(hydroxyalkyl) isocyanurate,(C) 0 to 45% by weight of at least one polyhydric alcohol other than the component (B),(D) 10 to 45% by weight of at least one polybasic acid, and(E) 0 to 15% by weight of at least one monobasic acidand an aqueous emulsion resin composition obtained by emulsion polymerization of a radical polymerizable unsaturated monomer in an aqueous medium in the presence of the aforesaid neutralization product. The above aqueous resin compositions can give a coating having excellent corrosion resistance and fast-drying property.

    摘要翻译： 一种含水树脂组合物，其包含在水性介质中含有酸值为5〜65的含异氰脲酸酯基的马来酸化醇酸树脂的中和产物，所述马来酸化的醇酸树脂通过使酸值不大于10的醇酸树脂 和（A）20至60重量％的干燥或半干性油和脂肪酸中的至少一种的缩合反应的产物的羟值为10以下，（B）10〜45重量％ 的至少一种三（羟烷基）异氰脲酸酯，（C）0至45重量％的除（B）成分以外的至少一种多元醇，（D）10至45重量％的至少一种多元酸，以及 （E）0〜15重量％的至少一种一元酸和通过自由基聚合性不饱和单体在水性介质中在上述中和产物的存在下乳液聚合得到的水性乳液树脂组合物。 上述水性树脂组合物可以得到具有优异的耐腐蚀性和快干性能的涂层。