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公开(公告)号：US08007730B2
公开(公告)日：2011-08-30
申请号：US12478787
申请日：2009-06-05
申请人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
发明人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
CPC分类号： B01J19/004
摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。
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2.发明申请Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 有权辐射敏感性纳米粒子和化疗药物辐射敏感性共聚物载体的制备方法公开(公告)号：US20160113884A1
公开(公告)日：2016-04-28
申请号：US14522583
申请日：2014-10-24
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
IPC分类号： A61K9/51 , A61K31/704
CPC分类号： A61K9/5146 , A61K9/5192 , A61K31/704
摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.
摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。
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公开(公告)号：US08181677B2
公开(公告)日：2012-05-22
申请号：US11868540
申请日：2007-10-08
申请人： Ming-Hsin Li , Wuu-Jyh Lin , Tain-Shi Zen
发明人： Ming-Hsin Li , Wuu-Jyh Lin , Tain-Shi Zen
IPC分类号： B67C3/00
CPC分类号： A61J1/2096 , B65B3/003 , G21G1/0005
摘要： An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.
摘要翻译： 用于放射性药物的自动分配器主要用于具有能够三维来回移动的移动机构的平台，注射器保持器和瓶保持器。 注射器支架用于容纳多个注射器。 瓶架有一个反向药瓶。 移动机构具有可绕水平轴线旋转的注射器夹具和注射器驱动机构。 注射器夹具被启动以保持注射器并将其移动到注射器针头插入药瓶的位置。 注射器驱动机构和注射器夹具同时与注射器相关联用于吸药动作。
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公开(公告)号：US09468608B2
公开(公告)日：2016-10-18
申请号：US14522583
申请日：2014-10-24
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
IPC分类号： A61K9/51 , A61K31/704
CPC分类号： A61K9/5146 , A61K9/5192 , A61K31/704
摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.
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公开(公告)号：US07757724B2
公开(公告)日：2010-07-20
申请号：US11458692
申请日：2006-07-20
申请人： Ming-Hsin Li , Wuu-Jyh Lin , Cheng-Hung Chien , Jun-Chieh Tsai , Wun-Shen Lan
发明人： Ming-Hsin Li , Wuu-Jyh Lin , Cheng-Hung Chien , Jun-Chieh Tsai , Wun-Shen Lan
IPC分类号： B65B31/04
摘要： An improved medication dispensing device includes an apyrexia receptacle, a transport pipeline, a perfusion device, a filter, and a dispensing needle, which operates in an environment in compliance with Class 100 laminar air ventilation. The perfusion device erected at the middle of the transport pipeline which has two ends linking to the apyrexia receptacle and the filter, respectively. In operation, the perfusion device pumps the prepared medication solution from the apyrexia receptacle to get through the filter to remove particles and bacterium, and a thin tubular dispensing needle which punctures the rubber plug of an aseptic bottle. An axial groove rendered in middle section of the dispensing needle forms a pressurized seal part with the rubber plug resiliently wrapped around at the middle of the dispensing needle to discharge redundant air pressure accumulating in the aseptic bottle while keeps outside air from entering.
摘要翻译： 改进的药物分配装置包括在符合Class100层流空气通风的环境中操作的apyrexia容器，输送管道，灌注装置，过滤器和分配针。 灌注装置竖立在输送管道的中部，分别具有两端连接到避孕套和过滤器。 在操作中，灌注装置将制备好的药物溶液从厌氧菌贮器中抽出，以通过过滤器去除颗粒和细菌;以及细管状分配针，其刺穿无菌瓶的橡胶塞。 在分配针的中间部分形成的轴向槽形成加压密封部分，橡胶塞弹性缠绕在分配针的中间，以排出积聚在无菌瓶中的多余的空气压力，同时保持外部空气不进入。
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公开(公告)号：US20080097370A1
公开(公告)日：2008-04-24
申请号：US11458692
申请日：2006-07-20
申请人： Ming-Hsin Li , Wuu-Jyh Lin , Cheng-Hung Chien , Jun-Chieh Tsai , Wun-Shen Lan
发明人： Ming-Hsin Li , Wuu-Jyh Lin , Cheng-Hung Chien , Jun-Chieh Tsai , Wun-Shen Lan
IPC分类号： A61B19/00
摘要： An improved medication dispensing device includes an apyrexia receptacle, a transport pipeline, a perfusion device, a filter, and a dispensing needle, which operates in an environment in compliance with Class 100 laminar air ventilation. The perfusion device erected at the middle of the transport pipeline which has two ends linking to the apyrexia receptacle and the filter, respectively. In operation, the perfusion device pumps the prepared medication solution from the apyrexia receptacle to get through the filter to remove particles and bacterium, and a thin tubular dispensing needle which punctures the rubber plug of an aseptic bottle. An axial groove rendered in middle section of the dispensing needle forms a pressurized seal part with the rubber plug resiliently wrapped around at the middle of the dispensing needle to discharge redundant air pressure accumulating in the aseptic bottle while keeps outside air from entering.
摘要翻译： 改进的药物分配装置包括在符合Class100层流空气通风的环境中操作的apyrexia容器，输送管道，灌注装置，过滤器和分配针。 灌注装置竖立在输送管道的中部，分别具有两端连接到避孕套和过滤器。 在操作中，灌注装置将制备好的药物溶液从厌氧菌贮器中抽出，以通过过滤器去除颗粒和细菌;以及细管状分配针，其刺穿无菌瓶的橡胶塞。 在分配针的中间部分形成的轴向槽形成加压密封部分，其中橡胶塞弹性缠绕在分配针的中间，以排出积聚在无菌瓶中的多余的空气压力，同时保持外部空气不进入。
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公开(公告)号：US09707521B2
公开(公告)日：2017-07-18
申请号：US13956375
申请日：2013-08-01
申请人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
发明人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
CPC分类号： B01D65/102 , B01D65/10 , G01M3/06
摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.
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公开(公告)号：US09277192B2
公开(公告)日：2016-03-01
申请号：US14049228
申请日：2013-10-09
申请人： Ming-Hsin Li
发明人： Ming-Hsin Li
摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.
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公开(公告)号：US08802014B2
公开(公告)日：2014-08-12
申请号：US13252195
申请日：2011-10-03
申请人： Ming-Hsin Li , Jin-Jenn Lin , Ther-Jen Ting , I-Lea Dai
发明人： Ming-Hsin Li , Jin-Jenn Lin , Ther-Jen Ting , I-Lea Dai
CPC分类号： G21G4/08 , A61K51/02 , G21G1/0005 , G21G2001/0021 , Y10S422/903
摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.
摘要翻译： 本发明涉及Ga-68放射性核素发生器的新型结构。 它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。 本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液 柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。
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公开(公告)号：US11077217B2
公开(公告)日：2021-08-03
申请号：US16215647
申请日：2018-12-11
申请人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
发明人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga67Ga68Ga177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.
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