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公开(公告)号：US09707521B2
公开(公告)日：2017-07-18
申请号：US13956375
申请日：2013-08-01
申请人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
发明人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
CPC分类号： B01D65/102 , B01D65/10 , G01M3/06
摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.
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2.发明申请Automated synthesis device to produce Re-188-Liposome and method thereof 审中-公开自动合成装置生产Re-188-脂质体及其方法公开(公告)号：US20140377169A1
公开(公告)日：2014-12-25
申请号：US13921217
申请日：2013-06-19
申请人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
发明人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
CPC分类号： B01J19/004 , A61K51/1234 , C07B59/001
摘要： An automated synthesis device to produce Re-188-BMEDA solution including: a plurality of reagent vials, three-way solenoid valves, gel filtration columns and micro pumps, and a reaction vial, a product vial, a temporary storage vial, a filter membrane, and a waste vial, wherein the plurality of reagent vials include first reagent vial and second reagent vials being connected to the reaction vial through first micro pump, the third reagent vial and fourth reagent vial being connected to the reaction vial through second micro pump, fifth reagent vial being connected to the reaction vial through third micro pump, and sixth reagent vial being connected to the temporary storage vial through fourth micro pump, wherein the reaction vial is connected to the plurality of gel filtration columns through the micro-pump, respectively. The automated synthesis device is operable with program to upgrade yield and avoid contamination.
摘要翻译： 一种用于生产Re-188-BMEDA溶液的自动化合成装置，包括：多个试剂瓶，三通电磁阀，凝胶过滤柱和微型泵，以及反应瓶，产品小瓶，临时储存小瓶，过滤膜 以及废物小瓶，其中所述多个试剂小瓶包括通过第一微泵连接到所述反应小瓶的第一试剂小瓶和第二试剂小瓶，所述第三试剂小瓶和第四试剂小瓶通过第二微泵连接到所述反应小瓶， 第五试剂小瓶通过第三微泵连接到反应小瓶，第六试剂小瓶通过第四微泵连接到临时存储小瓶，其中反应小瓶分别通过微型泵连接到多个凝胶过滤柱 。 自动合成装置可与程序一起操作，以提高产量并避免污染。
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3.发明申请Automated test apparatus for testing risk and integrity of pharmaceutical filtration membranes and method thereof 有权用于测试药物过滤膜的风险和完整性的自动化试验装置及其方法公开(公告)号：US20150033828A1
公开(公告)日：2015-02-05
申请号：US13956375
申请日：2013-08-01
申请人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
发明人： Ming-Hsin Li , Shu-Pei Chiu , Chih-Hsien Chang , Te-Wei Lee
IPC分类号： G01N15/08
CPC分类号： B01D65/102 , B01D65/10 , G01M3/06
摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.
摘要翻译： 一种用于药物过滤膜的风险和完整性测试的自动测试装置，包括至少以下组件：液体注射入口，泵，流体压力计，气体压力计，多个电磁阀，多个膜， 气体压力调节阀，药品瓶和气泡生成瓶。 本发明的自动测试装置由计算机软件与用于自动化测试的自动药物合成装置有关。 在使用本发明的自动测试装置时，仅需要在自动药物合成完成之后启动用于膜风险和完整性测试的自动测试装置的操作系统。 薄膜风险和完整性测试可以在短时间内通过测量气体和液体的压力同时在线排出的压力计来完成。
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公开(公告)号：US11077217B2
公开(公告)日：2021-08-03
申请号：US16215647
申请日：2018-12-11
申请人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
发明人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga67Ga68Ga177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.
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5.发明申请公开(公告)号：US20200237938A1
公开(公告)日：2020-07-30
申请号：US16215647
申请日：2018-12-11
申请人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
发明人： Ming-Hsin Li , Su-Jung Chen , Ming-Wei Chen , Yuan-Ruei Huang , Shih-Ying Lee , Chun-Fang Feng , Sheng-Nan Lo , Chih-Hsien Chang
摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga, 67Ga, 68Ga, 177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.
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6.发明申请Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 有权辐射敏感性纳米粒子和化疗药物辐射敏感性共聚物载体的制备方法公开(公告)号：US20160113884A1
公开(公告)日：2016-04-28
申请号：US14522583
申请日：2014-10-24
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Wei-Ming Li , Ming-Hsin Li
IPC分类号： A61K9/51 , A61K31/704
CPC分类号： A61K9/5146 , A61K9/5192 , A61K31/704
摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.
摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。
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公开(公告)号：US09277192B2
公开(公告)日：2016-03-01
申请号：US14049228
申请日：2013-10-09
申请人： Ming-Hsin Li
发明人： Ming-Hsin Li
摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.
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公开(公告)号：US08802014B2
公开(公告)日：2014-08-12
申请号：US13252195
申请日：2011-10-03
申请人： Ming-Hsin Li , Jin-Jenn Lin , Ther-Jen Ting , I-Lea Dai
发明人： Ming-Hsin Li , Jin-Jenn Lin , Ther-Jen Ting , I-Lea Dai
CPC分类号： G21G4/08 , A61K51/02 , G21G1/0005 , G21G2001/0021 , Y10S422/903
摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.
摘要翻译： 本发明涉及Ga-68放射性核素发生器的新型结构。 它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。 本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液 柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。
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公开(公告)号：US08007730B2
公开(公告)日：2011-08-30
申请号：US12478787
申请日：2009-06-05
申请人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
发明人： Ming-Hsin Li , Hsin-EII Wang , Chun-Yi Wu , Wuu-Jyh Lin
CPC分类号： B01J19/004
摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。
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公开(公告)号：US20150010447A1
公开(公告)日：2015-01-08
申请号：US13936219
申请日：2013-07-08
申请人： Ming-Hsin Li , Hsin-Han Hsieh
发明人： Ming-Hsin Li , Hsin-Han Hsieh
IPC分类号： C22B58/00
CPC分类号： C22B58/00 , C22B3/0004 , Y02P10/234
摘要： A method of purification for recycling of gallium-69 isotopes includes processes of proton irradiation and dissolution for a silver alloy plating target with gallium-69. After the proton irradiation and dissolution, a high concentration elution liquid of gallium-69 and germanium-68 is obtained by washing through an ion-exchange resin to filter out gallium-69 solution, followed by neutralizing precipitation, drying, and sintering treatments to obtain a gallium oxide. The gallium oxide can be dissolved to produce a solid target, and the washing processes can be repeated. The solid target after use can be placed in recycling again. This method is not only implemented to reduce the cost of production and comply with recycling notion nowadays, but also enhance efficiency in the practical application of radioisotopes.
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