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公开(公告)号：US12246029B2
公开(公告)日：2025-03-11
申请号：US17523034
申请日：2021-11-10
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: A61K31/7105 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07K14/505 , C12N15/10 , C12P19/34 , G01N33/68
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US20220339185A1
公开(公告)日：2022-10-27
申请号：US17850702
申请日：2022-06-27
Applicant: ModernaTX, Inc.
Inventor： Meredith Packer , Dipendra Gyawali , Serenus Hua , Gabor Butora , Gregory John Mercer
IPC: A61K31/7105 , A61K9/16
Abstract: Provided herein are compositions and methods of reducing adduct formation.
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公开(公告)号：US10570388B2
公开(公告)日：2020-02-25
申请号：US16008658
申请日：2018-06-14
Applicant: ModernaTX, Inc.
Inventor： Gabor Butora , Matthew Stanton , Thomas Steele
IPC: C12N15/11 , C12N15/10 , C07H21/02 , C07D473/18 , C07D473/34
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.
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公开(公告)号：US20180363019A1
公开(公告)日：2018-12-20
申请号：US16001786
申请日：2018-06-06
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: C12P19/34
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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公开(公告)号：US11866754B2
公开(公告)日：2024-01-09
申请号：US15768206
申请日：2016-10-17
Applicant: ModernaTX, Inc.
Inventor： Gabor Butora , Matthew Stanton , Edward John Miracco
IPC: C12P19/34 , C07H21/02 , A61K31/7125 , C12N9/12 , C12N15/10 , C12N15/113
CPC classification number: C12P19/34 , A61K31/7125 , C07H21/02 , C12N9/1247 , C12N15/1096 , C12N15/113 , C12N2310/317 , C12Y207/07006
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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Patent Agency Ranking
公开(公告)号：US11622972B2
公开(公告)日：2023-04-11
申请号：US17850702
申请日：2022-06-27
Applicant: ModernaTX, Inc.
Inventor： Meredith Packer , Dipendra Gyawali , Serenus Hua , Gabor Butora , Gregory John Mercer
IPC: A61K31/7105 , A61K9/16
Abstract: Provided herein are compositions and methods of reducing adduct formation.
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公开(公告)号：US11434486B2
公开(公告)日：2022-09-06
申请号：US15760667
申请日：2016-09-19
Applicant: ModernaTX, Inc.
Inventor： Gabor Butora , Andrew W. Fraley , Edward John Miracco , Jennifer Nelson , Amy Rhoden Smith , Matthew Stanton
IPC: A01N43/04 , A61K31/70 , C12N15/113 , C12N15/11
Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
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公开(公告)号：US10428106B2
公开(公告)日：2019-10-01
申请号：US16008655
申请日：2018-06-14
Applicant: ModernaTX, Inc.
Inventor： Gabor Butora , Matthew Stanton , Thomas Steele
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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公开(公告)号：US10286086B2
公开(公告)日：2019-05-14
申请号：US15319840
申请日：2015-06-19
Applicant: ModernaTX, Inc.
Inventor： Atanu Roy , Christopher R. Conlee , Antonin De Fougerolles , Andrew W. Fraley , Gabor Butora , Matthew Stanton
IPC: A61K48/00 , C07F9/6558 , C07H19/06 , C07H19/16 , C12N15/11 , C12N15/67 , C07H21/02 , C07F9/6561 , C07D405/04 , C07D239/54 , C07H19/067 , C07H19/10 , C07H19/14 , C07H19/167 , C07H19/20 , C07H19/23 , C07D473/16 , C07D473/18 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C07D487/16 , C07D498/22 , C12N15/87
Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
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公开(公告)号：US20220096522A1
公开(公告)日：2022-03-31
申请号：US17523060
申请日：2021-11-10
Applicant: ModernaTX, Inc.
Inventor： Stephen Hoge , William Issa , Edward J. Miracco , Jennifer Nelson , Amy E. Rabideau , Gabor Butora
IPC: A61K31/7105 , C07K14/505 , C12P19/34 , A61P33/00 , A61P31/12 , A61P31/04 , A61P35/00 , C12N15/10 , G01N33/68
Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
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