公开(公告)号：US12071620B2

公开(公告)日：2024-08-27

申请号：US17929956

申请日：2022-09-06

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton

IPC: C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/351 ,  C12N2320/51

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

公开(公告)号：US20180009866A1

公开(公告)日：2018-01-11

申请号：US15656740

申请日：2017-07-21

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  William Joseph Issa ,  Edward John Miracco ,  Jennifer Nelson ,  John Reynders ,  Matthew Stanton

IPC: C07K14/535 ,  C07K14/505 ,  C12N9/02 ,  C12P19/34

CPC classification number: C07K14/535 ,  A61K48/005 ,  C07K14/505 ,  C12N9/0069 ,  C12P19/34 ,  C12P21/02 ,  C12Y113/12007

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

公开(公告)号：US10570388B2

公开(公告)日：2020-02-25

申请号：US16008658

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Thomas Steele

IPC: C12N15/11 ,  C12N15/10 ,  C07H21/02 ,  C07D473/18 ,  C07D473/34

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.

公开(公告)号：US10072057B2

公开(公告)日：2018-09-11

申请号：US15656740

申请日：2017-07-21

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  William Joseph Issa ,  Edward John Miracco ,  Jennifer Nelson ,  John Reynders ,  Matthew Stanton

IPC: C07K14/535 ,  C12P19/34 ,  C07K14/505 ,  C12N9/00 ,  A61K48/00 ,  C12P21/02 ,  C12N9/02

CPC classification number: C07K14/535 ,  A61K48/005 ,  C07K14/505 ,  C12N9/0069 ,  C12P19/34 ,  C12P21/02 ,  C12Y113/12007

Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

公开(公告)号：US10563195B2

公开(公告)日：2020-02-18

申请号：US16008662

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Thomas Steele

IPC: C12N15/11 ,  C12N15/10 ,  C07H21/02 ,  C07D473/18 ,  C07D473/34

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.

公开(公告)号：US11866754B2

公开(公告)日：2024-01-09

申请号：US15768206

申请日：2016-10-17

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Edward John Miracco

IPC: C12P19/34 ,  C07H21/02 ,  A61K31/7125 ,  C12N9/12 ,  C12N15/10 ,  C12N15/113

CPC classification number: C12P19/34 ,  A61K31/7125 ,  C07H21/02 ,  C12N9/1247 ,  C12N15/1096 ,  C12N15/113 ,  C12N2310/317 ,  C12Y207/07006

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US20230323344A1

公开(公告)日：2023-10-12

申请号：US17929956

申请日：2022-09-06

Applicant: ModernaTx, Inc.

Inventor： Gabor BUTORA ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton

IPC: C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/351 ,  C12N2320/51

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

公开(公告)号：US11434486B2

公开(公告)日：2022-09-06

申请号：US15760667

申请日：2016-09-19

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton

IPC: A01N43/04 ,  A61K31/70 ,  C12N15/113 ,  C12N15/11

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

公开(公告)号：US10428106B2

公开(公告)日：2019-10-01

申请号：US16008655

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Thomas Steele

IPC: C07H21/00 ,  C07H21/02

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US10385088B2

公开(公告)日：2019-08-20

申请号：US15026836

申请日：2014-10-02

Applicant: ModernaTX, Inc.

Inventor： Andrew W. Fraley ,  Atanu Roy ,  Matthew Stanton

IPC: C07H19/10 ,  C07H19/067 ,  C07H19/167 ,  C07H21/02 ,  C07H19/20 ,  C07K14/525 ,  C07K14/535 ,  C07K14/565

Abstract: The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.